Search Results - "Fenart, L"

Evaluation of effect of charge and lipid coating on ability of 60-nm nanoparticles to cross an in vitro model of the blood-brain barrier by Fenart, L, Casanova, A, Dehouck, B, Duhem, C, Slupek, S, Cecchelli, R, Betbeder, D

“…A cell culture model of the blood-brain barrier (BBB) consisting of a coculture of bovine brain capillary endothelial cells and rat astrocytes has been used to…”
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Behavior of alpha-, beta-, and gamma-cyclodextrins and their derivatives on an in vitro model of blood-brain barrier by Monnaert, V, Tilloy, S, Bricout, H, Fenart, L, Cecchelli, R, Monflier, E

“…Cyclodextrins (CDs) can be envisaged to cure some diseases related to the brain, but the behavior of these compounds toward the blood-brain barrier (BBB)…”
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Prediction of drug transport through the blood-brain barrier in vivo: A comparison between two in vitro cell models by LUNDQUIST, Stefan, RENFTEL, Mila, BRILLAULT, Julien, FENART, Laurence, CECCHELLI, Roméo, DEHOUCK, Marie-Pierre

“…Studies were conducted to evaluate whether the use of an in vitro model of the blood-brain barrier (BBB) resulted in more accurate predictions of the in vivo…”
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In vitro model for evaluating drug transport across the blood–brain barrier by Cecchelli, R, Dehouck, B, Descamps, L, Fenart, L, Buée-Scherrer, V, Duhem, C, Lundquist, S, Rentfel, M, Torpier, G, Dehouck, M.P

“…The passage of substances across the blood–brain barrier (BBB) is regulated in the cerebral capillaries, which possess certain distinct different morphological…”
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Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity by OLIVIER, J.-C, FENART, L, CHAUVET, R, PARIAT, C, CECCHELLI, R, COUET, W

“…To investigate the mechanism underlying the entry of the analgesic peptide dalargin into brain using biodegradable polybutylcyanoacrylate (PBCA) nanoparticles…”
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In vitro models for the blood–brain barrier by Garberg, P., Ball, M., Borg, N., Cecchelli, R., Fenart, L., Hurst, R.D., Lindmark, T., Mabondzo, A., Nilsson, J.E., Raub, T.J., Stanimirovic, D., Terasaki, T., Öberg, J.-O., Österberg, T.

“…The aim of the present study was to identify a model for the blood–brain barrier based on the use of a continuous cell line, and to investigate the specificity…”
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Evidence of lowest brain penetration of an antiemetic drug, metopimazine, compared to domperidone, metoclopramide and chlorpromazine, using an in vitro model of the blood–brain barrier by Jolliet, Pascale, Nion, Stéphane, Allain-Veyrac, Gwenaëlle, Tilloy-Fenart, L., Vanuxeem, Dorothée, Berezowski, Vincent, Cecchelli, Roméo

“…The objective of the current study was to determine the ability of some antiemetic compounds to cross the blood–brain barrier (BBB) and thereby to determine…”
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Effects of gamma- and hydroxypropyl-gamma-cyclodextrins on the transport of doxorubicin across an in vitro model of blood-brain barrier by Monnaert, V, Betbeder, D, Fenart, L, Bricout, H, Lenfant, A M, Landry, C, Cecchelli, R, Monflier, E, Tilloy, S

“…Association between doxorubicin (DOX) and gamma-cyclodextrin (gamma-CD) or hydroxypropyl-gamma-CD (HP-gamma-CD) has been examined to increase the delivery of…”
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Transport screening of drug cocktails through an in vitro blood-brain barrier: is it a good strategy for increasing the throughput of the discovery pipeline? by Berezowski, V, Landry, C, Lundquist, S, Dehouck, L, Cecchelli, R, Dehouck, M P, Fenart, L

“…The objective of the current study was to investigate whether blood-brain barrier (BBB) permeability studies in vitro could be accelerated by running several…”
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Astrocytes are mainly responsible for the polyunsaturated fatty acid enrichment in blood-brain barrier endothelial cells in vitro by Bernoud, N, Fenart, L, Bénistant, C, Pageaux, J F, Dehouck, M P, Molière, P, Lagarde, M, Cecchelli, R, Lecerf, J

“…To determine the respective roles of endothelial cells from brain capillaries and astrocytes in the conversion of circulating 18:2n-6 and 18:3n-3 into 20:4n-6…”
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Efficient Docosahexaenoic Acid Uptake by the Brain from a Structured Phospholipid by Hachem, Mayssa, Géloën, Alain, Van, Amanda Lo, Foumaux, Baptiste, Fenart, Laurence, Gosselet, Fabien, Da Silva, Pedro, Breton, Gildas, Lagarde, Michel, Picq, Madeleine, Bernoud-Hubac, Nathalie

“…Docosahexaenoic acid (DHA) is the main essential omega-3 fatty acid in brain tissues required for normal brain development and function. An alteration of brain…”
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Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood–brain barrier: Use of an in vitro model by Gosselet, Fabien, Candela, Pietra, Sevin, Emmanuel, Berezowski, Vincent, Cecchelli, Roméo, Fenart, Laurence

“…Abstract Brain is the most cholesterol rich organ of the whole body and recent studies suggest a role for the blood–brain barrier (BBB) in cerebral cholesterol…”
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Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood–brain barrier by Berezowski, Vincent, Landry, Christophe, Dehouck, Marie-Pierre, Cecchelli, Roméo, Fenart, Laurence

“…P-glycoprotein (P-gp) and the multidrug resistance-associated proteins (MRP), whose expression is associated with multidrug resistance, have been recently…”
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Mouse syngenic in vitro blood-brain barrier model : a new tool to examine inflammatory events in cerebral endothelium by COISNE, Caroline, DEHOUCK, Lucie, DEHOUCK, Bénédicte, FAVEEUW, Christelle, DELPLACE, Yannick, MILLER, Florence, LANDRY, Christophe, MORISSETTE, Céline, FENART, Laurence, CECCHELLI, Romeo, TREMBLAY, Patrick

“…Although cerebral endothelium disturbance is commonly observed in central nervous system (CNS) inflammatory pathologies, neither the cause of this phenomenon…”
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An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening by Culot, Maxime, Lundquist, Stefan, Vanuxeem, Dorothée, Nion, Stéphane, Landry, Christophe, Delplace, Yannick, Dehouck, Marie-Pierre, Berezowski, Vincent, Fenart, Laurence, Cecchelli, Roméo

“…There is a growing interest to use in vitro BBB cell assays in early safety assessment of compounds. By modifying a well-validated co-culture model of brain…”
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High transcytosis of melanotransferrin (P97) across the blood–brain barrier by Demeule, Michel, Poirier, Julie, Jodoin, Julie, Bertrand, Yanick, Desrosiers, Richard R., Dagenais, Claude, Nguyen, Tran, Lanthier, Julie, Gabathuler, Reinhard, Kennard, Malcolm, Jefferies, Wilfred A., Karkan, Delara, Tsai, Sam, Fenart, Laurence, Cecchelli, Roméo, Béliveau, Richard

“…The blood–brain barrier (BBB) performs a neuroprotective function by tightly controlling access to the brain; consequently it also impedes access of proteins…”
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A New Function for the LDL Receptor: Transcytosis of LDL across the Blood-Brain Barrier by Dehouck, Bénédicte, Fenart, Laurence, Dehouck, Marie-Pierre, Pierce, Annick, Torpier, Gérard, Cecchelli, Roméo

“…Lipoprotein transport across the blood-brain barrier (BBB) is of critical importance for the delivery of essential lipids to the brain cells. The occurrence of…”
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Receptor-mediated Transcytosis of Lactoferrin through the Blood-Brain Barrier by Fillebeen, Carine, Descamps, Laurence, Dehouck, Marie-Pierre, Fenart, Laurence, Benaı̈ssa, Monique, Spik, Geneviève, Cecchelli, Roméo, Pierce, Annick

“…Lactoferrin (Lf) is an iron-binding protein involved in host defense against infection and severe inflammation; it accumulates in the brain during…”
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P‐glycoprotein in blood–brain barrier endothelial cells: interaction and oligomerization with caveolins by Jodoin, Julie, Demeule, Michel, Fenart, Laurence, Cecchelli, Roméo, Farmer, Sarah, Linton, Kenneth J., Higgins, Christopher F., Béliveau, Richard

“…P‐glycoprotein (P‐gp), an adenosine triphosphate (ATP)‐binding cassette transporter which acts as a drug efflux pump, is highly expressed at the blood–brain…”
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Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: An in vitro study by Culot, Maxime, Mysiorek, Caroline, Renftel, Mila, Roussel, Benoit D, Hommet, Yannick, Vivien, Denis, Cecchelli, Roméo, Fenart, Laurence, Berezowski, Vincent, Dehouck, Marie-Pierre, Lundquist, Stefan

“…Abstract NXY-059, a polar compound with limited transport across the blood-brain barrier, has demonstrated neuroprotection in several animal models of acute…”
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