Search Results - "Felts, Sara J."

Celastrol Inhibits Hsp90 Chaperoning of Steroid Receptors by Inducing Fibrillization of the Co-chaperone p23 by Chadli, Ahmed, Felts, Sara J., Wang, Qin, Sullivan, William P., Botuyan, Maria Victoria, Fauq, Abdul, Ramirez-Alvarado, Marina, Mer, Georges

“…Hsp90 is an ATP-dependent molecular chaperone. The best characterized inhibitors of Hsp90 target its ATP binding pocket, causing nonselective degradation of…”
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Chaperoning Checkpoint Kinase 1 (Chk1), an Hsp90 Client, with Purified Chaperones by Arlander, Sonnet J.H., Felts, Sara J., Wagner, Jill M., Stensgard, Bridget, Toft, David O., Karnitz, Larry M.

“…Checkpoint kinase 1 (Chk1), a serine/threonine kinase that regulates DNA damage checkpoints, is destabilized when heat shock protein 90 (Hsp90) is inhibited,…”
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Widespread Non-Canonical Epigenetic Modifications in MMTV-NeuT Breast Cancer by Felts, Sara J, Van Keulen, Virginia P, Hansen, Michael J, Bell, Michael P, Allen, Kathleen, Belachew, Alem A, Vile, Richard G, Cunningham, Julie M, Hoskin, Tanya L, Pankratz, V. Shane, Pease, Larry R

“…Abstract Breast tumors in (FVB × BALB-NeuT) F1 mice have characteristic loss of chromosome 4 and sporadic loss or gain of other chromosomes. We employed the…”
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GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway by Chadli, Ahmed, Graham, J. Dinny, Abel, M. Greg, Jackson, Twila A., Gordon, David F., Wood, William M., Felts, Sara J., Horwitz, Kathryn B., Toft, David

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Synthesis of novel fluorescent probes for the molecular chaperone Hsp90 by Llauger-Bufi, Laura, Felts, Sara J, Huezo, Henri, Rosen, Neal, Chiosis, Gabriela

“…Heat shock protein 90 (Hsp90) is a molecular chaperone necessary for maintaining oncogenic transformation. There is substantial interest in developing novel…”
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Exploring the effect of library preparation on RNA sequencing experiments by Wang, Lei, Felts, Sara J., Van Keulen, Virginia P., Pease, Larry R., Zhang, Yuji

“…RNA sequencing (RNA-seq) has become the widely preferred choice for surveying the genome-wide transcriptome complexity in many organisms. However, the broad…”
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Integrative Genome-Wide Analysis of Long Noncoding RNAs in Diverse Immune Cell Types of Melanoma Patients by Wang, Lei, Felts, Sara J, Van Keulen, Virginia P, Scheid, Adam D, Block, Matthew S, Markovic, Svetomir N, Pease, Larry R, Zhang, Yuji

“…Genome-wide identification and characterization of long noncoding RNAs (lncRNA) in individual immune cell lineages helps us better understand the driving…”
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Regulation of Heat Shock Protein 90 ATPase Activity by Sequences in the Carboxyl Terminus by Owen, Barbara A.L., Sullivan, William P., Felts, Sara J., Toft, David O.

“…hsp90, in addition to being an abundant and pivotal cytoplasmic chaperone protein, has been shown to be a weak ATPase. In an effort to characterize the ATPase…”
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Indirect recruitment of a CD40 signaling pathway in dendritic cells by B7-DC cross-linking antibody modulates T cell functions by Radhakrishnan, Suresh, Cabrera, Rosalyn, Bruns, Kristina M, Van Keulen, Virginia P, Hansen, Michael J, Felts, Sara J, Pease, Larry R

“…The human IgM B7-DC XAb protects mice from tumors in both therapeutic and prophylactic settings. Its mechanism of action is mediated by its binding to…”
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Reprogrammed FoxP3+ T Regulatory Cells Become IL-17+ Antigen-Specific Autoimmune Effectors In Vitro and In Vivo by Radhakrishnan, Suresh, Cabrera, Rosalyn, Schenk, Erin L, Nava-Parada, Pilar, Bell, Michael P, Van Keulen, Virginia P, Marler, Ronald J, Felts, Sara J, Pease, Larry R

“…Lymphocyte differentiation from naive CD4(+) T cells into mature Th1, Th2, Th17, or T regulatory cell (Treg) phenotypes has been considered end stage in…”
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Gene Expression Signatures Characterized by Longitudinal Stability and Interindividual Variability Delineate Baseline Phenotypic Groups with Distinct Responses to Immune Stimulation by Scheid, Adam D, Van Keulen, Virginia P, Felts, Sara J, Neier, Steven C, Middha, Sumit, Nair, Asha A, Techentin, Robert W, Gilbert, Barry K, Jen, Jin, Neuhauser, Claudia, Zhang, Yuji, Pease, Larry R

“…Human immunity exhibits remarkable heterogeneity among individuals, which engenders variable responses to immune perturbations in human populations. Population…”
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GCUNC45 Is the First Hsp90 Co-chaperone to Show α/β Isoform Specificity by Chadli, Ahmed, Felts, Sara J., Toft, David O.

“…Hsp90 is an essential molecular chaperone required for the normal functioning of many key regulatory proteins in eukaryotic cells. Vertebrates have two closely…”
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The hsp90-related Protein TRAP1 Is a Mitochondrial Protein with Distinct Functional Properties by Felts, Sara J., Owen, Barbara A.L., Nguyen, PhuongMai, Trepel, Jane, Donner, David B., Toft, David O.

“…The hsp90 family of molecular chaperones was expanded recently due to the cloning of TRAP1 and hsp75 by yeast two-hybrid screens. Careful analysis of the human…”
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Gene expression patterns in CD4+ peripheral blood cells in healthy subjects and stage IV melanoma patients by Felts, Sara J., Van Keulen, Virginia P., Scheid, Adam D., Allen, Kathleen S., Bradshaw, Renee K., Jen, Jin, Peikert, Tobias, Middha, Sumit, Zhang, Yuji, Block, Matthew S., Markovic, Svetomir N., Pease, Larry R.

“…Melanoma patients exhibit changes in immune responsiveness in the local tumor environment, draining lymph nodes, and peripheral blood. Immune-targeting…”
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p23, a simple protein with complex activities by Felts, Sara J., Toft, David O.

“…p23 is a small but important cochaperone for the Hsp90 chaperoning pathway. It appears to facilitate the adenosine triphosphate–driven cycle of Hsp90 binding…”
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Characterization of plant p23-like proteins for their co-chaperone activities by Zhang, Zhongming, Sullivan, William, Felts, Sara J., Prasad, Bishun D., Toft, David O., Krishna, Priti

“…The small acidic protein p23 is best described as a co-chaperone of Hsp90, an essential molecular chaperone in eukaryotes. p23 binds to the ATP-bound form of…”
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Stochastic changes in gene expression promote chaotic dysregulation of homeostasis in clonal breast tumors by Felts, Sara J., Tang, Xiaojia, Willett, Benjamin, Van Keulen, Virginia P., Hansen, Michael J., Kalari, Krishna R., Pease, Larry R.

“…Cells within tumors vary in phenotype as a result of changes in gene expression caused by a variety of mechanisms, permitting cancers to evolve under selective…”
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The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies by Freeman, B C, Felts, S J, Toft, D O, Yamamoto, K R

“…Multiple molecular chaperones, including Hsp90 and p23, interact with members of the intracellular receptor (IR) family. To investigate p23 function, we…”
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Crystal Structure and Activity of Human p23, a Heat Shock Protein 90 Co-chaperone by Weaver, Arthur J., Sullivan, William P., Felts, Sara J., Owen, Barbara A.L., Toft, David O.

“…p23 is a co-chaperone for the heat shock protein, hsp90. This protein binds hsp90 and participates in the folding of a number of cell regulatory proteins, but…”
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Functioning of the Hsp90 machine in chaperoning checkpoint kinase 1 (Chk1) and the progesterone receptor (PR) by Felts, Sara J., Karnitz, Larry M., Toft, David O.

“…Hsp90 is an abundant and highly conserved chaperone that functions at later stages of protein folding to maintain and regulate the activity of client proteins…”
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