Search Results - "Felter, Susan P."

Butylated hydroxyanisole: Carcinogenic food additive to be avoided or harmless antioxidant important to protect food supply? by Felter, Susan P., Zhang, Xiaoling, Thompson, Chad

“…Tumor data from rodent bioassays are used for cancer hazard classification with wide-ranging consequences. This paper presents a case study of the synthetic…”
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A Cautionary tale for using read-across for cancer hazard classification: Case study of isoeugenol and methyl eugenol by Zhang, Xiaoling, Felter, Susan P., Api, Anne Marie, Joshi, Kaushal, Selechnik, Dan

“…Chemical grouping and read-across are frequently used non-animal alternatives for filling toxicological data gaps. When grouping chemicals, it is critical to…”
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Correlation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern by Laufersweiler, Michael C., Gadagbui, Bernard, Baskerville-Abraham, Irene M., Maier, Andrew, Willis, Alison, Scialli, Anthony R., Carr, Gregory J., Felter, Susan P., Blackburn, Karen, Daston, George

“…► We assembled a large database of reproductive and developmental toxicity data. ► We analyzed data to calculated thresholds of toxicological concern. ► We…”
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Bolstering the existing database supporting the non-cancer Threshold of Toxicological Concern values with toxicity data on fragrance-related materials by Patel, Atish, Joshi, Kaushal, Rose, Jane, Laufersweiler, Michael, Felter, Susan P., Api, Anne Marie

“…The use of threshold of toxicological concern (TTC) supports the safety assessment of exposure to low levels of chemicals when toxicity data are limited. The…”
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How the 62-year old Delaney Clause continues to thwart science: Case study of the flavor substance β-myrcene by Felter, Susan P., Llewelyn, Craig, Navarro, Lisa, Zhang, Xiaoling

“…The Delaney Clause is a provision of the 1958 Food Additive Amendment to the Food, Drug and Cosmetic Act of 1938 which stipulates that if a substance is found…”
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Thresholds of Toxicological Concern for cosmetics-related substances: New database, thresholds, and enrichment of chemical space by Yang, Chihae, Barlow, Susan M., Muldoon Jacobs, Kristi L., Vitcheva, Vessela, Boobis, Alan R., Felter, Susan P., Arvidson, Kirk B., Keller, Detlef, Cronin, Mark T.D., Enoch, Steven, Worth, Andrew, Hollnagel, Heli M.

“…A new dataset of cosmetics-related chemicals for the Threshold of Toxicological Concern (TTC) approach has been compiled, comprising 552 chemicals with 219,…”
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Understanding fragrance allergy using an exposure‐based risk assessment approach by Gerberick, G. Frank, Robinson, Michael K, Felter, Susan P, White, Ian R, Basketter, David A

“…Conducting a sound skin sensitization risk assessment prior to the introduction of new ingredients and products into the market place is essential. The process…”
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Assessing chemical carcinogenicity: hazard identification, classification, and risk assessment. Insight from a Toxicology Forum state-of-the-science workshop by Felter, Susan P., Bhat, Virunya S., Botham, Philip A., Bussard, David A., Casey, Warren, Hayes, A. Wallace, Hilton, Gina M., Magurany, Kelly A., Sauer, Ursula G., Ohanian, Edward V.

“…The Toxicology Forum convened an international state-of-the-science workshop Assessing Chemical Carcinogenicity: Hazard Identification, Classification, and…”
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A review of the scientific basis for uncertainty factors for use in quantitative risk assessment for the induction of allergic contact dermatitis by Felter, Susan P., Robinson, Michael K., Basketter, David A., Gerberick, G. Frank

“…Safety evaluations for chemicals which possess the ability to cause sensitization by skin contact have traditionally been done using an ad hoc comparative risk…”
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Human relevance of rodent liver tumors: Key insights from a Toxicology Forum workshop on nongenotoxic modes of action by Felter, Susan P., Foreman, Jennifer E., Boobis, Alan, Corton, J. Christopher, Doi, Adriana M., Flowers, Lynn, Goodman, Jay, Haber, Lynne T., Jacobs, Abigail, Klaunig, James E., Lynch, Angela M., Moggs, Jonathan, Pandiri, Arun

“…The Toxicology Forum sponsored a workshop in October 2016, on the human relevance of rodent liver tumors occurring via nongenotoxic modes of action (MOAs). The…”
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Application of the risk assessment paradigm to the induction of allergic contact dermatitis by Felter, Susan P, Ryan, Cindy A, Basketter, David A, Gilmour, Nicola J, Gerberick, G.Frank

“…The National Academy of Science (NAS) risk assessment paradigm has been widely accepted as a framework for estimating risk from exposure to environmental…”
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Hazard identification, classification, and risk assessment of carcinogens: too much or too little? - Report of an ECETOC workshop by Felter, Susan P., Boobis, Alan R., Botham, Philip A., Brousse, Alice, Greim, Helmut, Hollnagel, Heli M., Sauer, Ursula G.

“…The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) organized a workshop "Hazard Identification, Classification and Risk Assessment of…”
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Letter to the editor regarding recent publication titled “Developing an internal threshold of toxicological concern (iTTC)” by Arnot et al. (2022) by Ellison, Corie A., Arnot, Jon A., Felter, Susan P., Daston, George P., Becker, Richard A., Toose, Liisa, Armitage, James M., Sangion, Alessandro, Looky, Alexandra, Brown, Trevor N., Li, Li

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Assessment of health risks resulting from early-life exposures: Are current chemical toxicity testing protocols and risk assessment methods adequate? by Felter, Susan P., Daston, George P., Euling, Susan Y., Piersma, Aldert H., Tassinari, Melissa S.

“…Abstract Over the last couple of decades, the awareness of the potential health impacts associated with early-life exposures has increased. Global regulatory…”
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Workshop report on the evaluation of the updated and expanded carcinogen database to support derivation of threshold of toxicological concern values for DNA-reactive carcinogens by Escher, Sylvia E, Felter, Susan P, Hollnagel, Heli, Boobis, Alan R, Yang, Chihae, Rathman, James, Cronin, Mark T D, Batke, Monika

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Utilizing Threshold of Toxicological Concern (TTC) with high throughput exposure predictions (HTE) as a risk-based prioritization approach for thousands of chemicals by Patlewicz, Grace, Wambaugh, John F., Felter, Susan P., Simon, Ted W., Becker, Richard A.

“…•An approach of using TTC and HTE to facilitate risk-based prioritization is presented.•Used the Kroes et al. (2004) workflow to identify the number of…”
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Safety evaluation for ingredients used in baby care products: Consideration of diaper rash by Felter, Susan P., Carr, Andrew N., Zhu, Tingting, Kirsch, Taryn, Niu, Gloria

“…Diaper rash can adversely impact the barrier properties of skin, with potential implications for increased absorption of chemicals through the skin, and this…”
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A proposed framework for assessing risk from less-than-lifetime exposures to carcinogens by Felter, Susan P., Conolly, Rory B., Bercu, Joel P., Bolger, P. Michael, Boobis, Alan R., Bos, Peter M. J., Carthew, Philip, Doerrer, Nancy G., Goodman, Jay I., Harrouk, Wafa A., Kirkland, David J., Lau, Serrine S., Llewellyn, G. Craig, Preston, R. Julian, Schoeny, Rita, Schnatter, A. Robert, Tritscher, Angelika, van Velsen, Frans, Williams, Gary M.

“…Quantitative methods for estimation of cancer risk have been developed for daily, lifetime human exposures. There are a variety of studies or methodologies…”
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Application of the threshold of toxicological concern approach to ingredients in personal and household care products by Blackburn, Karen, Stickney, Julie A., Carlson-Lynch, Heather L., McGinnis, Patricia M., Chappell, Lara, Felter, Susan P.

“…In the absence of chemical-specific data, the threshold of toxicological concern (TTC) provides a method to determine a conservative estimate of a chronic oral…”
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Evolution of Science-Based Uncertainty Factors in Noncancer Risk Assessment by Dourson, Michael L., Felter, Susan P., Robinson, Denise

“…The science behind the use of uncertainty factors has progressed considerably. Increased knowledge of inter- and intraspecies sensitivity, mechanisms of…”
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