Search Results - "Felsovalyi, Klara"

Single-Cell Identity Generated by Combinatorial Homophilic Interactions between α, β, and γ Protocadherins by Thu, Chan Aye, Chen, Weisheng V., Rubinstein, Rotem, Chevee, Maxime, Wolcott, Holly N., Felsovalyi, Klara O., Tapia, Juan Carlos, Shapiro, Lawrence, Honig, Barry, Maniatis, Tom

“…Individual mammalian neurons stochastically express distinct repertoires of α, β, and γ protocadherin (Pcdh) proteins, which function in neural circuit…”
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The Extracellular Architecture of Adherens Junctions Revealed by Crystal Structures of Type I Cadherins by Harrison, Oliver J., Jin, Xiangshu, Hong, Soonjin, Bahna, Fabiana, Ahlsen, Goran, Brasch, Julia, Wu, Yinghao, Vendome, Jeremie, Felsovalyi, Klara, Hampton, Cheri M., Troyanovsky, Regina B., Ben-Shaul, Avinoam, Frank, Joachim, Troyanovsky, Sergey M., Shapiro, Lawrence, Honig, Barry

“…Adherens junctions, which play a central role in intercellular adhesion, comprise clusters of type I classical cadherins that bind via extracellular domains…”
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Structural and energetic determinants of adhesive binding specificity in type I cadherins by Vendome, Jeremie, Felsovalyi, Klara, Song, Hang, Yang, Zhongyu, Jin, Xiangshu, Brasch, Julia, Harrison, Oliver J., Ahlsen, Goran, Bahna, Fabiana, Kaczynska, Anna, Katsamba, Phinikoula S., Edmond, Darwin, Hubbell, Wayne L., Shapiro, Lawrence, Honig, Barry

“…Type I cadherin cell-adhesion proteins are similar in sequence and structure and yet are different enough to mediate highly specific cell-cell recognition…”
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Structural Model of the Extracellular Assembly of the TCR-CD3 Complex by Natarajan, Aswin, Nadarajah, Vidushan, Felsovalyi, Klara, Wang, Wenjuan, Jeyachandran, Vivian R., Wasson, Riley A., Cardozo, Timothy, Bracken, Clay, Krogsgaard, Michelle

“…Antigen recognition of peptide-major histocompatibility complexes (pMHCs) by T cells, a key step in initiating adaptive immune responses, is performed by the…”
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Molecular basis of atypicality of bupropion inferred from its receptor engagement in nervous system tissues by Kim, Eric J., Felsovalyi, Klara, Young, Lauren M., Shmelkov, Sergey V., Grunebaum, Michael F., Cardozo, Timothy

“…Despite decades of clinical use and research, the mechanism of action (MOA) of antidepressant medications remains poorly understood. Selective serotonin…”
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Quantitative Analysis of T Cell Receptor Complex Interaction Sites Using Genetically Encoded Photo-Cross-Linkers by Wang, Wenjuan, Li, Tianqi, Felsovalyi, Klara, Chen, Chunlai, Cardozo, Timothy, Krogsgaard, Michelle

“…The T cell receptor (TCR)-cluster of differentiation 3 (CD3) signaling complex plays an important role in initiation of adaptive immune responses, but weak…”
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Structural and Energetic Determinants of Adhesive Binding Specificity in Type I Cadherins: The Role of Multiple Conformations in Tuning Affinities by Song, Hang, Yang, Zhongyu, Felsovalyi, Klara, Hubbell, Wayne, Shapiro, Lawrence, Honig, Barry

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Data sources for in vivo molecular profiling of human phenotypes by Cardozo, Timothy, Gupta, Priyanka, Ni, Eric, Young, Lauren M., Tivon, Doreen, Felsovalyi, Klara

“…Molecular profiling of human diseases has been approached at the genetic (DNA), expression (RNA), and proteomic (protein) levels. An important goal of these…”
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Cover Image, Volume 8, Issue 6 by Cardozo, Timothy, Gupta, Priyanka, Ni, Eric, Young, Lauren M., Tivon, Doreen, Felsovalyi, Klara

“…The cover image, by Timothy Cardozo et al., is based on the Advanced Review Data sources for in vivo molecular profiling of human phenotypes , DOI:…”
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Generation of single cell identity by homophilic interactions between combinations of α, β and γ protocadherins by Thu, Chan Aye, Chen, Weisheng V., Rubinstein, Rotem, Chevee, Maxime, Wolcott, Holly N, Felsovalyi, Klara O, Tapia, Juan Carlos, Shapiro, Lawrence, Honig, Barry, Maniatis, Tom

“…Individual mammalian neurons express distinct repertoires of protocadherin (Pcdh) -α, -β and -γ proteins that function in neural circuit assembly. Here we show…”
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Learning from cadherin structures and sequences: affinity determinants and protein architecture by Felsovalyi, Klara

“…Cadherins are a family of cell-surface proteins mediating adhesion that are important in development and maintenance of tissues. The family is defined by the…”
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Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca2+-free interdomain linkers by Jin, Xiangshu, Walker, Melissa A, Felsövályi, Klára, Vendome, Jeremie, Bahna, Fabiana, Mannepalli, Seetha, Cosmanescu, Filip, Ahlsen, Goran, Honig, Barry, Shapiro, Lawrence

“…Vertebrate classical cadherins mediate selective calcium-dependent cell adhesion by mechanisms now understood at the atomic level. However, structures and…”
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Distinct sequence patterns characterize the V3 region of HIV type 1 gp120 from subtypes A and C by Felsövályi, Klára, Nádas, Arthur, Zolla-Pazner, Susan, Cardozo, Timothy

“…The known sequences of HIV-1 viruses have been categorized into subtypes based on the phylogenetic partitioning of their env and gag gene sequences. The env…”
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Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca^sup 2+^-free interdomain linkers by Jin, Xiangshu, Walker, Melissa A, Felsövályi, Klára, Vendome, Jeremie, Bahna, Fabiana, Mannepalli, Seetha, Cosmanescu, Filip, Ahlsen, Goran, Honig, Barry, Shapiro, Lawrence

“…Vertebrate classical cadherins mediate selective calcium-dependent cell adhesion by mechanisms now understood at the atomic level. However, structures and…”
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Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca2+-free interdomain linkers by Jin, Xiangshu, Walker, Melissa A., Felsövályi, Klára, Vendome, Jeremie, Bahna, Fabiana, Mannepalli, Seetha, Cosmanescu, Filip, Ahlsen, Goran, Honig, Barry, Shapiro, Lawrence

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Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca 2+ -free interdomain linkers by Jin, Xiangshu, Walker, Melissa A., Felsövályi, Klára, Vendome, Jeremie, Bahna, Fabiana, Mannepalli, Seetha, Cosmanescu, Filip, Ahlsen, Goran, Honig, Barry, Shapiro, Lawrence

“…Vertebrate classical cadherins mediate selective calcium-dependent cell adhesion by mechanisms now understood at the atomic level. However, structures and…”
Get full text