Search Results - "Felsenfeld, Gary"

CTCF: making the right connections by Ghirlando, Rodolfo, Felsenfeld, Gary

“…The role of the zinc finger protein CTCF in organizing the genome within the nucleus is now well established. Widely separated sites on DNA, occupied by both…”
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Nucleosome stability mediated by histone variants H3.3 and H2A.Z by Jin, Chunyuan, Felsenfeld, Gary

“…Nucleosomes containing the histone variant H3.3 tend to be clustered in vivo in the neighborhood of transcriptionally active genes and over regulatory…”
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Insulators: exploiting transcriptional and epigenetic mechanisms by Felsenfeld, Gary, Gaszner, Miklos

“…Insulators are DNA sequence elements that prevent inappropriate interactions between adjacent chromatin domains. One type of insulator establishes domains that…”
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Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects by Jian, Xing, Felsenfeld, Gary

“…Previous GWAS studies identified non-coding loci with parent-of-origin-specific effects on Type 2 diabetes susceptibility. Here we report the molecular basis…”
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H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions by Zhao, Keji, Felsenfeld, Gary, Jin, Chunyuan, Zang, Chongzhi, Wei, Gang, Cui, Kairong, Peng, Weiqun

“…To understand how chromatin structure is organized by different histone variants, we have measured the genome-wide distribution of nucleosome core particles…”
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Specific Sites in the C Terminus of CTCF Interact with the SA2 Subunit of the Cohesin Complex and Are Required for Cohesin-Dependent Insulation Activity by Xiao, Tiaojiang, Wallace, Julie, Felsenfeld, Gary

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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We gather together: insulators and genome organization by Wallace, Julie A, Felsenfeld, Gary

“…When placed between an enhancer and promoter, certain DNA sequence elements inhibit enhancer-stimulated gene expression. The best characterized of these…”
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Association of the Long Non-coding RNA Steroid Receptor RNA Activator (SRA) with TrxG and PRC2 Complexes by Wongtrakoongate, Patompon, Riddick, Gregory, Fucharoen, Suthat, Felsenfeld, Gary

“…Long non-coding RNAs (lncRNAs) have been recognized as key players in transcriptional regulation. We show that the lncRNA steroid receptor RNA activator (SRA)…”
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Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA by Yao, Hongjie, Brick, Kevin, Evrard, Yvonne, Xiao, Tiaojiang, Camerini-Otero, R Daniel, Felsenfeld, Gary

“…CCCTC-binding factor (CTCF) is a DNA-binding protein that plays important roles in chromatin organization, although the mechanism by which CTCF carries out…”
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Interactome mapping defines BRG1, a component of the SWI/SNF chromatin remodeling complex, as a new partner of the transcriptional regulator CTCF by Marino, Maria Michela, Rega, Camilla, Russo, Rosita, Valletta, Mariangela, Gentile, Maria Teresa, Esposito, Sabrina, Baglivo, Ilaria, De Feis, Italia, Angelini, Claudia, Xiao, Tioajiang, Felsenfeld, Gary, Chambery, Angela, Pedone, Paolo Vincenzo

“…The highly conserved zinc finger CCCTC-binding factor (CTCF) regulates genomic imprinting and gene expression by acting as a transcriptional activator or…”
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human insulin gene is part of a large open chromatin domain specific for human islets by Mutskov, Vesco, Felsenfeld, Gary

“…Knowledge of how insulin (INS) gene expression is regulated will lead to better understanding of normal and abnormal pancreatic β cell function. We have mapped…”
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Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9 by Mutskov, Vesco, Felsenfeld, Gary

“…Transgenes stably integrated into cells or animals in many cases are silenced rapidly, probably under the influence of surrounding endogenous condensed…”
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Chromatin domains, insulators, and the regulation of gene expression by Ghirlando, Rodolfo, Giles, Keith, Gowher, Humaira, Xiao, Tiaojiang, Xu, Zhixiong, Yao, Hongjie, Felsenfeld, Gary

“…The DNA sequence elements called insulators have two basic kinds of properties. Barrier elements block the propagation of heterochromatic structures into…”
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Chromatin as an essential part of the transcriptional mechanim by Felsenfeld, Gary

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Methylation of histone H4 by arginine methyltransferase PRMT1 is essential in vivo for many subsequent histone modifications by Huang, Suming, Litt, Michael, Felsenfeld, Gary

“…PRMT1 is a histone methyltransferase that methylates Arg3 on histone H4. When we used siRNA to knock down PRMT1 in an erythroid cell line, it resulted in…”
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CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites by Xiao, Tiaojiang, Wongtrakoongate, Patompon, Trainor, Cecelia, Felsenfeld, Gary

“…The role of CTCF in stabilizing long-range interactions between chromatin sites essential for maintaining nuclear architecture is well established. Most of…”
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Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene by Felsenfeld, Gary, Bell, Adam C

“…The expression of the insulin-like growth factor 2 (Igf2) and H19 genes is imprinted. Although these neighbouring genes share an enhancer, H19 is expressed…”
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Chromatin structure outside and inside the nucleus by Ghirlando, Rodolfo, Felsenfeld, Gary

“…The structure of the 30‐nm chromatin fiber has provided, over the years, an important reference in chromatin studies. Originally derived from electron…”
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Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription by Felsenfeld, Gary, Xu, Zhixiong, Wei, Gang, Chepelev, Iouri, Zhao, Keji

“…Insulin secretion from pancreatic b cells is tightly regulated. Using chromosome conformation capture techniques, it is now found that the insulin promoter…”
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Insulators: many functions, many mechanisms by West, Adam G, Gaszner, Miklos, Felsenfeld, Gary

“…"Insulator" is the name given to a class of DNA sequence elements that possess a common ability to protect genes from inappropriate signals emanating from…”
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