Search Results - "Felsburg, Peter J"

Rapid immune reconstitution of SCID-X1 canines after G-CSF/AMD3100 mobilization and in vivo gene therapy by Humbert, Olivier, Chan, Frieda, Rajawat, Yogendra S., Torgerson, Troy R., Burtner, Christopher R., Hubbard, Nicholas W., Humphrys, Daniel, Norgaard, Zachary K., O'Donnell, Patricia, Adair, Jennifer E., Trobridge, Grant D., Scharenberg, Andrew M., Felsburg, Peter J., Rawlings, David J., Kiem, Hans-Peter

“…Hematopoietic stem-cell gene therapy is a promising treatment of X-linked severe combined immunodeficiency disease (SCID-X1), but currently, it requires…”
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Severe Papillomavirus Infection Progressing to Metastatic Squamous Cell Carcinoma in Bone Marrow-Transplanted X-Linked SCID Dogs by GOLDSCHMIDT, Michael H, KENNEDY, Jeffrey S, HARTNETT, Brian J, WEINBERG, Kenneth I, SCHLEGEL, Richard, FELSBURG, Peter J, KENNEDY, Douglas R, HANG YUAN, HOLT, David E, CASAL, Margret L, TRAAS, Anne M, MAULDIN, Elizabeth A, MOORE, Peter F, HENTHORN, Paula S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Characterization of colonic dendritic cells in normal and colitic mice by Cruickshank, Sheena M, English, Nicholas R, Felsburg, Peter J, Carding, Simon R

“…Recent studies demonstrating the direct involvement of dendritic cells (DC) in the activation of pathogenic T cells in animal models of inflammatory bowel…”
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Correction of canine X-linked severe combined immunodeficiency by in vivo retroviral gene therapy by Ravin, Suk See Ting–De, Kennedy, Douglas R., Naumann, Nora, Kennedy, Jeffrey S., Choi, Uimook, Hartnett, Brian J., Linton, Gilda F., Whiting-Theobald, Narda L., Moore, Peter F., Vernau, William, Malech, Harry L., Felsburg, Peter J.

“…X-linked severe combined immunodeficiency (XSCID) is characterized by profound immunodeficiency and early mortality, the only potential cure being…”
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Expression and function of TLR2, TLR4, and Nod2 in primary canine colonic epithelial cells by Swerdlow, Mathew P., Kennedy, Douglas R., Kennedy, Jeffrey S., Washabau, Robert J., Henthorn, Paula S., Moore, Peter F., Carding, Simon R., Felsburg, Peter J.

“…The gut maintains a delicate balance between the downregulation of inflammatory reactions to commensal bacteria and the capacity to respond to pathogens with…”
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Intravenous injection of a foamy virus vector to correct canine SCID-X1 by Burtner, Christopher R., Beard, Brian C., Kennedy, Douglas R., Wohlfahrt, Martin E., Adair, Jennifer E., Trobridge, Grant D., Scharenberg, Andrew M., Torgerson, Troy R., Rawlings, David J., Felsburg, Peter J., Kiem, Hans-Peter

“…Current approaches to hematopoietic stem cell (HSC) gene therapy involve the collection and ex vivo manipulation of HSCs, a process associated with loss of…”
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Isolation and characterization of pediatric canine bone marrow CD34 + cells by Suter, Steven E., Gouthro, Terry A., McSweeney, Peter A., Nash, Richard A., Haskins, Mark E., Felsburg, Peter J., Henthorn, Paula S.

“…Historically, the dog has been a valuable model for bone marrow transplantation studies, with many of the advances achieved in the dog being directly…”
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Gene therapy studies in a canine model of X-linked severe combined immunodeficiency by Felsburg, Peter J, De Ravin, Suk See, Malech, Harry L, Sorrentino, Brian P, Burtner, Christopher, Kiem, Hans-Peter

“…Since the occurrence of T cell leukemias in the original human γ-retroviral gene therapy trials for X-linked severe combined immunodeficiency (XSCID),…”
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Ex vivo γ-retroviral gene therapy of dogs with X-linked severe combined immunodeficiency and the development of a thymic T cell lymphoma by Kennedy, Douglas R., Hartnett, Brian J., Kennedy, Jeffrey S., Vernau, William, Moore, Peter F., O’Malley, Thomas, Burkly, Linda C., Henthorn, Paula S., Felsburg, Peter J.

“…We have previously shown that in vivo γ-retroviral gene therapy of dogs with X-linked severe combined immunodeficiency (XSCID) results in sustained T cell…”
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Marking of peripheral T-lymphocytes by retroviral transduction and transplantation of CD34 + cells in a canine X-linked severe combined immunodeficiency model by Suter, Steven E., Gouthro, Terry A., O’Malley, Thomas, Hartnett, Brian J., McSweeney, Peter A., Moore, Peter F., Felsburg, Peter J., Haskins, Mark E., Henthorn, Paula S.

“…A retrovirus vector containing an enhanced green fluorescent protein complimentary DNA (EGFP cDNA) was used to mark and dynamically follow vector-expressing…”
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Frequent respiratory tract infections in the canine model of X-linked ectodermal dysplasia are not caused by an immune deficiency by Casal, Margret L., Mauldin, Elizabeth A., Ryan, Sara, Scheidt, Jennifer L., Kennedy, Jeffrey, Moore, Peter F., Felsburg, Peter J.

“…As in many human patients with X-linked hypohidrotic ectodermal dysplasia (XHED), XHED dogs are at an increased risk for pulmonary disorders. Localized immune…”
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Response to Malassezia pachydermatis by peripheral blood mononuclear cells from clinically normal and atopic dogs by Morris, Daniel O, Clayton, Daniel J, Drobatz, Kenneth J, Felsburg, Peter J

“…To investigate the potential cell-mediated immune response of atopic dogs to the yeast Malassezia pachydermatis and to correlate it with the type-1…”
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Canine X-linked severe combined immunodeficiency by Felsburg, Peter J, Hartnett, Brian J, Henthorn, Paula S, Moore, Peter F, Krakowka, Steven, D. Ochs, Hans

“…Canine X-linked severe combined immunodeficiency (XSCID) is due to mutations in the common gamma (γc) subunit of the IL-2, IL-4, IL-7, IL-9 and IL-15…”
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Thymopoiesis and T cell development in common gamma chain-deficient dogs by Felsburg, Peter J, Hartnett, Brian J, Gouthro, Terry A, Henthorn, Paula S

“…Our laboratory has identified an X-linked severe combined immunodeficiency (XSCID) in dogs that is the result of mutations in the common gamma chain (gammac)…”
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Effect of Ex Vivo Culture of CD34+ Bone Marrow Cells on Immune Reconstitution of XSCID Dogs Following Allogeneic Bone Marrow Transplantation by Kennedy, Douglas R, McLellan, Kyle, Moore, Peter F, Henthorn, Paula S, Felsburg, Peter J

“…Successful genetic treatment of most primary immunodeficiencies or hematological disorders will require the transduction of pluripotent, self-renewing…”
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B-cell function in canine X-linked severe combined immunodeficiency by Hartnett, Brian J, Somberg, Richard L, Krakowka, Steven, Ochs, Hans D, HogenEsch, Harm, Moore, Peter F, Weinberg, Kenneth I, Felsburg, Peter J

“…Canine X-linked severe combined immunodeficiency (XSCID) is due to mutations in the common gamma (γc) subunit of the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors…”
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Bone marrow transplantation for canine X-linked severe combined immunodeficiency by Hartnett, Brian J, Henthorn, Paula S, Moore, Peter F, Weinberg, Kenneth I, Ochs, Hans D, Felsburg, Peter J

“…Canine X-linked severe combined immunodeficiency (XSCID) is due to mutations in the common γ chain which is a subunit of the receptors of IL-2, IL-4, IL-7,…”
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284. Long-Term Therapeutic Immune Reconstitution in XSCID Canine Model via In Vivo Foamy Virus Delivery of Common Gamma Chain by Chan, Frieda, Humbert, Olivier, Burtner, Christopher, Humphrys, Daniel, Adair, Jennifer, Trobridge, Grant, O'Donnell, Patricia, Hubbard, Nicholas, Torgerson, Troy, Scharenberg, Andrew, Rawlings, David, Felsburg, Peter J., Kiem, Hans-Peter

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Robust Therapeutic Expression of the Common Gamma Chain with the Human Pgk Promoter Using Foamy Virus in Vivo Gene Therapy in a Canine Model of Severe Combined Immunodeficiency by Burtner, Christopher R, Humbert, Olivier, O’Donnell, Patricia, Hubbard, Nicholas, Humphrys, Daniel, Adair, Jennifer E, Trobridge, Grant D, Torgerson, Troy R, Scharenberg, Andrew M, Rawlings, David, Felsburg, Peter J, Kiem, Hans-Peter

“…In vivo gene therapy has several benefits over ex vivo hematopoietic stem cell gene therapy, including the correction of progenitor cells in their native…”
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441. Direct Comparison of EF1α and PGK Promoters Reveals Superior Performance of the PGK Promoter for Expression of the Common Gamma Chain in a Canine Model of In Vivo Foamy Virus Gene Therapy for Severe Combined Immunodeficiency by Burtner, Christopher R., Olivier, Humbert, O'Donnell, Patricia, Hubbard, Nicholas, Humphrys, Daniel, Adair, Jennifer E., Trobridge, Grant D., Torgerson, Troy R., Scharenberg, Andrew M., Rawlings, David J., Felsburg, Peter J., Kiem, Hans-Peter

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