Search Results - "Fels, Johannes J."

Prolonged insulin-induced hypoglycaemia reduces ß-cell activity rather than number in pancreatic islets in non-diabetic rats by Jensen, Vivi F. H., Mølck, Anne-Marie, Nowak, Jette, Fels, Johannes J., Lykkesfeldt, Jens, Bøgh, Ingrid B.

“…Pancreatic β-cells have an extraordinary ability to adapt to acute fluctuations in glucose levels by rapid changing insulin production to meet metabolic needs…”
Get full text

Improved leptin sensitivity and increased soluble leptin receptor concentrations may underlie the additive effects of combining PYY(3–36) and exendin-4 on body weight lowering in diet-induced obese mice by Wulff, Birgitte S., Kuhre, Rune Ehrenreich, Selvaraj, Madhan, Rehfeld, Jens F., Niss, Kristoffer, Fels, Johannes J., Anna, Secher, Raun, Kirsten, Gerstenberg, Marina Kjaergaard

“…Co-treatment with long acting PYY and the GLP-1 receptor agonists has potential as an efficient obesity treatment. This study investigates whether the…”
Get full text

The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model by Rojas, Jennifer M., Bolze, Florian, Thorup, Inger, Nowak, Jette, Dalsgaard, Charlotte M., Skydsgaard, Mikala, Berthelsen, Line O., Keane, Kevin A., Søeborg, Henrik, Sjögren, Ingrid, Jensen, Jes T., Fels, Johannes J., Offenberg, Hanne K., Andersen, Lærke W., Dalgaard, Majken

“…The obese rodent serves as an indispensable tool for proof-of-concept efficacy and mode-of-action pharmacology studies. Yet the utility of this disease model…”
Get full text

NKX6.1 induced pluripotent stem cell reporter lines for isolation and analysis of functionally relevant neuronal and pancreas populations by Gupta, Shailesh Kumar, Wesolowska-Andersen, Agata, Ringgaard, Anna K., Jaiswal, Himjyot, Song, Luyan, Hastoy, Benoit, Ingvorsen, Camilla, Taheri-Ghahfarokhi, Amir, Magnusson, Björn, Maresca, Marcello, Jensen, Rikke R., Beer, Nicola L., Fels, Johannes J., Grunnet, Lars G., Thomas, Melissa K., Gloyn, Anna L., Hicks, Ryan, McCarthy, Mark I., Hansson, Mattias, Honoré, Christian

“…Recent studies have reported significant advances in the differentiation of human pluripotent stem cells to clinically relevant cell types such as the insulin…”
Get full text

Glucose-sensitive insulin with attenuation of hypoglycaemia by Hoeg-Jensen, Thomas, Kruse, Thomas, Brand, Christian L., Sturis, Jeppe, Fledelius, Christian, Nielsen, Peter K., Nishimura, Erica, Madsen, Alice R., Lykke, Lennart, Halskov, Kim S., Koščová, Simona, Kotek, Vladislav, Davis, Anthony P., Tromans, Robert A., Tomsett, Michael, Peñuelas-Haro, Guillem, Leonard, Daniel J., Orchard, Michael G., Chapman, Andy, Invernizzi, Gaetano, Johansson, Eva, Granata, Daniele, Hansen, Bo F., Pedersen, Thomas A., Kildegaard, Jonas, Pedersen, Karen-Margrethe, Refsgaard, Hanne H. F., Alifrangis, Lene, Fels, Johannes J., Neutzsky-Wulff, Anita V., Sauerberg, Per, Slaaby, Rita

“…The risk of inducing hypoglycaemia (low blood glucose) constitutes the main challenge associated with insulin therapy for diabetes 1 , 2 . Insulin doses must…”
Get full text

FGF21 decreases food intake and body weight in obese Göttingen minipigs by Christoffersen, Berit, Straarup, Ellen M., Lykkegaard, Kirsten, Fels, Johannes J., Sass‐Ørum, Kristian, Zhang, Xujia, Raun, Kirsten, Andersen, Birgitte

“…Aims The aim of this study was to assess the effect of FGF21 on food intake, body weight, body composition, glucose homeostasis, bone mineral density (BMD),…”
Get full text

UCP1-independent glucose-lowering effect of leptin in type 1 diabetes: only in conditions of hypoleptinemia by Zouhar, Petr, Rakipovski, Günaj, Bokhari, Muhammad Hamza, Busby, Oliver, Paulsson, Johan F, Conde-Frieboes, Kilian W, Fels, Johannes J, Raun, Kirsten, Andersen, Birgitte, Cannon, Barbara, Nedergaard, Jan

“…The possibility to use leptin therapeutically for lowering glucose levels in patients with type 1 diabetes has attracted interest. However, earlier animal…”
Get more information

Long-Acting Human Growth Hormone Analogue by Noncovalent Albumin Binding by Ramírez-Andersen, Henrik S, Behrens, Carsten, Buchardt, Jens, Fels, Johannes J, Folkesson, Charlotta G, Jianhe, Chen, Nørskov-Lauritsen, Leif, Nielsen, Per F, Reslow, Mats, Rischel, Christian, Su, Jing, Thygesen, Peter, Wiberg, Charlotte, Zhao, Xin, Wenjuan, Xia, Johansen, Nils L

“…The present work describes a series of human growth hormone (hGH) albumin binder conjugates with an extended in vivo half-life. A broad range of different…”
Get full text

The counterregulatory response to hypoglycaemia in the pig by Gradel, Anna Katrina J., Kildegaard, Jonas, Ludvigsen, Trine P., Porsgaard, Trine, Schou‐Pedersen, Anne Marie V., Fels, Johannes J., Lykkesfeldt, Jens, Refsgaard, Hanne H. F.

“…The domestic pig is commonly used as animal model in the pharmaceutical development of new therapeutics for treatment of diabetes. Since a formal definition of…”
Get full text

Inner histopathologic changes and disproportionate zone volumes in foetal growth plates following gestational hypoglycaemia in rats by Jensen, Vivi F. H., Mølck, Anne-Marie, Bøgh, Ingrid B., Nowak, Jette, Viuff, Birgitte M., Rasmussen, Charlotte L. M., Pedersen, Louise, Fels, Johannes J., Madsen, Suzi H., McGuigan, Fiona E., Tveden-Nyborg, Pernille, Lykkesfeldt, Jens, Akesson, Kristina E.

“…Maternal hypoglycaemia throughout gestation until gestation day (GD)20 delays foetal growth and skeletal development. While partially prevented by return to…”
Get full text

In Situ Phosphorylation of Akt and ERK1/2 in Rat Mammary Gland, Colon, and Liver Following Treatment with Human Insulin and IGF-1 by Hvid, Henning, Fels, Johannes J., Kirk, Rikke K., Thorup, Inger, Jensen, Henrik E., Hansen, Bo F., Oleksiewicz, Martin B.

“…High doses of insulin and the insulin analog AspB10 have been reported to increase mammary tumor incidence in female rats likely via receptor-mediated…”
Get full text