Search Results - "Fels, J. Maximilian"

Broad neutralization of SARS-related viruses by human monoclonal antibodies by Wec, Anna Z, Wrapp, Daniel, Herbert, Andrew S, Maurer, Daniel P, Haslwanter, Denise, Sakharkar, Mrunal, Jangra, Rohit K, Dieterle, M Eugenia, Lilov, Asparouh, Huang, Deli, Tse, Longping V, Johnson, Nicole V, Hsieh, Ching-Lin, Wang, Nianshuang, Nett, Juergen H, Champney, Elizabeth, Burnina, Irina, Brown, Michael, Lin, Shu, Sinclair, Melanie, Johnson, Carl, Pudi, Sarat, Bortz, 3rd, Robert, Wirchnianski, Ariel S, Laudermilch, Ethan, Florez, Catalina, Fels, J Maximilian, O'Brien, Cecilia M, Graham, Barney S, Nemazee, David, Burton, Dennis R, Baric, Ralph S, Voss, James E, Chandran, Kartik, Dye, John M, McLellan, Jason S, Walker, Laura M

“…Broadly protective vaccines against known and preemergent human coronaviruses (HCoVs) are urgently needed. To gain a deeper understanding of cross-neutralizing…”
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A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition by Dieterle, M. Eugenia, Haslwanter, Denise, Bortz, Robert H., Wirchnianski, Ariel S., Lasso, Gorka, Vergnolle, Olivia, Abbasi, Shawn A., Fels, J. Maximilian, Laudermilch, Ethan, Florez, Catalina, Mengotto, Amanda, Kimmel, Duncan, Malonis, Ryan J., Georgiev, George, Quiroz, Jose, Barnhill, Jason, Pirofski, Liise-anne, Daily, Johanna P., Dye, John M., Lai, Jonathan R., Herbert, Andrew S., Chandran, Kartik, Jangra, Rohit K.

“…There is an urgent need for vaccines and therapeutics to prevent and treat COVID-19. Rapid SARS-CoV-2 countermeasure development is contingent on the…”
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Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies by Mishra, Akaash K, Hellert, Jan, Freitas, Natalia, Guardado-Calvo, Pablo, Haouz, Ahmed, Fels, J Maximilian, Maurer, Daniel P, Abelson, Dafna M, Bornholdt, Zachary A, Walker, Laura M, Chandran, Kartik, Cosset, François-Loïc, McLellan, Jason S, Rey, Felix A

“…Crimean-Congo hemorrhagic fever virus (CCHFV) is the most widespread tick-borne zoonotic virus, with a 30% case fatality rate in humans. Structural information…”
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Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses by Wec, Anna Z., Herbert, Andrew S., Murin, Charles D., Nyakatura, Elisabeth K., Abelson, Dafna M., Fels, J. Maximilian, He, Shihua, James, Rebekah M., de La Vega, Marc-Antoine, Zhu, Wenjun, Bakken, Russell R., Goodwin, Eileen, Turner, Hannah L., Jangra, Rohit K., Zeitlin, Larry, Qiu, Xiangguo, Lai, Jonathan R., Walker, Laura M., Ward, Andrew B., Dye, John M., Chandran, Kartik, Bornholdt, Zachary A.

“…Experimental monoclonal antibody (mAb) therapies have shown promise for treatment of lethal Ebola virus (EBOV) infections, but their species-specific…”
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Protocadherin-1 is essential for cell entry by New World hantaviruses by Jangra, Rohit K., Herbert, Andrew S., Li, Rong, Jae, Lucas T., Kleinfelter, Lara M., Slough, Megan M., Barker, Sarah L., Guardado-Calvo, Pablo, Román-Sosa, Gleyder, Dieterle, M. Eugenia, Kuehne, Ana I., Muena, Nicolás A., Wirchnianski, Ariel S., Nyakatura, Elisabeth K., Fels, J. Maximilian, Ng, Melinda, Mittler, Eva, Pan, James, Bharrhan, Sushma, Wec, Anna Z., Lai, Jonathan R., Sidhu, Sachdev S., Tischler, Nicole D., Rey, Félix A., Moffat, Jason, Brummelkamp, Thijn R., Wang, Zhongde, Dye, John M., Chandran, Kartik

“…The zoonotic transmission of hantaviruses from their rodent hosts to humans in North and South America is associated with a severe and frequently fatal…”
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Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability by Zhao, Xuelian, Howell, Katie A., He, Shihua, Brannan, Jennifer M., Wec, Anna Z., Davidson, Edgar, Turner, Hannah L., Chiang, Chi-I., Lei, Lin, Fels, J. Maximilian, Vu, Hong, Shulenin, Sergey, Turonis, Ashley N., Kuehne, Ana I., Liu, Guodong, Ta, Mi, Wang, Yimeng, Sundling, Christopher, Xiao, Yongli, Spence, Jennifer S., Doranz, Benjamin J., Holtsberg, Frederick W., Ward, Andrew B., Chandran, Kartik, Dye, John M., Qiu, Xiangguo, Li, Yuxing, Aman, M. Javad

“…While neutralizing antibodies are highly effective against ebolavirus infections, current experimental ebolavirus vaccines primarily elicit species-specific…”
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A Glycoprotein Mutation That Emerged during the 2013-2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion by Fels, J Maximilian, Bortz, 3rd, Robert H, Alkutkar, Tanwee, Mittler, Eva, Jangra, Rohit K, Spence, Jennifer S, Chandran, Kartik

“…Genomic surveillance of viral isolates during the 2013-2016 Ebola virus epidemic in Western Africa, the largest and most devastating filovirus outbreak on…”
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A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry by Fels, J Maximilian, Spence, Jennifer S, Bortz, 3rd, Robert H, Bornholdt, Zachary A, Chandran, Kartik

“…Ebola virus (EBOV) causes highly lethal disease outbreaks against which no FDA-approved countermeasures are available. Although many host factors exploited by…”
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Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics by Durham, Natasha D, Howard, Angela R, Govindan, Ramesh, Senjobe, Fernando, Fels, J Maximilian, Diehl, William E, Luban, Jeremy, Chandran, Kartik, Munro, James B

“…The Ebola virus (EBOV) envelope glycoprotein (GP) mediates the fusion of the virion membrane with the membrane of susceptible target cells during infection…”
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Treatment of severe COVID-19 with convalescent plasma in Bronx, NYC by Yoon, Hyun Ah, Bartash, Rachel, Gendlina, Inessa, Rivera, Johanna, Nakouzi, Antonio, Bortz, 3rd, Robert H, Wirchnianski, Ariel S, Paroder, Monika, Fehn, Karen, Serrano-Rahman, Leana, Babb, Rachelle, Sarwar, Uzma N, Haslwanter, Denise, Laudermilch, Ethan, Florez, Catalina, Dieterle, M Eugenia, Jangra, Rohit K, Fels, J Maximilian, Tong, Karen, Mariano, Margarette C, Vergnolle, Olivia, Georgiev, George I, Herrera, Natalia G, Malonis, Ryan J, Quiroz, Jose A, Morano, Nicholas C, Krause, Gregory J, Sweeney, Joseph M, Cowman, Kelsie, Allen, Stephanie, Annam, Jayabhargav, Applebaum, Ariella, Barboto, Daniel, Khokhar, Ahmed, Lally, Brianna J, Lee, Audrey, Lee, Max, Malaviya, Avinash, Sample, Reise, Yang, Xiuyi A, Li, Yang, Ruiz, Rafael, Thota, Raja, Barnhill, Jason, Goldstein, Doctor Y, Uehlinger, Joan, Garforth, Scott J, Almo, Steven C, Lai, Jonathan R, Gil, Morayma Reyes, Fox, Amy S, Chandran, Kartik, Wang, Tao, Daily, Johanna P, Pirofski, Liise-Anne

“…Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) antibodies (CCP) may hold promise as a treatment for coronavirus disease…”
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Single-Dilution COVID-19 Antibody Test with Qualitative and Quantitative Readouts by Bortz, 3rd, Robert H, Florez, Catalina, Laudermilch, Ethan, Wirchnianski, Ariel S, Lasso, Gorka, Malonis, Ryan J, Georgiev, George I, Vergnolle, Olivia, Herrera, Natalia G, Morano, Nicholas C, Campbell, Sean T, Orner, Erika P, Mengotto, Amanda, Dieterle, M Eugenia, Fels, J Maximilian, Haslwanter, Denise, Jangra, Rohit K, Celikgil, Alev, Kimmel, Duncan, Lee, James H, Mariano, Margarette C, Nakouzi, Antonio, Quiroz, Jose, Rivera, Johanna, Szymczak, Wendy A, Tong, Karen, Barnhill, Jason, Forsell, Mattias N E, Ahlm, Clas, Stein, Daniel T, Pirofski, Liise-Anne, Goldstein, D Yitzchak, Garforth, Scott J, Almo, Steven C, Daily, Johanna P, Prystowsky, Michael B, Faix, James D, Fox, Amy S, Weiss, Louis M, Lai, Jonathan R, Chandran, Kartik

“…The coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to place an immense…”
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Exploiting Pre-Existing CD4 + T Cell Help from Bacille Calmette-Guérin Vaccination to Improve Antiviral Antibody Responses by Ng, Tony W, Wirchnianski, Ariel S, Wec, Anna Z, Fels, J Maximilian, Johndrow, Christopher T, Saunders, Kevin O, Liao, Hua-Xin, Chan, John, Jacobs, Jr, William R, Chandran, Kartik, Porcelli, Steven A

“…The continuing emergence of viral pathogens and their rapid spread into heavily populated areas around the world underscore the urgency for development of…”
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Genomic surveillance of SARS-CoV-2 during the first year of the pandemic in the Bronx enabled clinical and epidemiological inference by Fels, J Maximilian, Khan, Saad, Forster, Ryan, Skalina, Karin A, Sirichand, Surksha, Fox, Amy S, Bergman, Aviv, Mitchell, William B, Wolgast, Lucia R, Szymczak, Wendy A, Bortz, 3rd, Robert H, Dieterle, M Eugenia, Florez, Catalina, Haslwanter, Denise, Jangra, Rohit K, Laudermilch, Ethan, Wirchnianski, Ariel S, Barnhill, Jason, Goldman, David L, Khine, Hnin, Goldstein, D Yitzchak, Daily, Johanna P, Chandran, Kartik, Kelly, Libusha

“…The Bronx was an early epicenter of the COVID-19 pandemic in the USA. We conducted temporal genomic surveillance of 104 SARS-CoV-2 genomes across the Bronx…”
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Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever by Fels, J. Maximilian, Maurer, Daniel P., Herbert, Andrew S., Wirchnianski, Ariel S., Vergnolle, Olivia, Cross, Robert W., Abelson, Dafna M., Moyer, Crystal L., Mishra, Akaash K., Aguilan, Jennifer T., Kuehne, Ana I., Pauli, Noel T., Bakken, Russell R., Nyakatura, Elisabeth K., Hellert, Jan, Quevedo, Gregory, Lobel, Leslie, Balinandi, Stephen, Lutwama, Julius J., Zeitlin, Larry, Geisbert, Thomas W., Rey, Felix A., Sidoli, Simone, McLellan, Jason S., Lai, Jonathan R., Bornholdt, Zachary A., Dye, John M., Walker, Laura M., Chandran, Kartik

“…Crimean-Congo hemorrhagic fever virus (CCHFV) is a World Health Organization priority pathogen. CCHFV infections cause a highly lethal hemorrhagic fever for…”
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Exploiting pre-existing CD4+ T cell help from BCG vaccination to improve anti-viral antibody responses by Ng, Tony W., Wirchnianski, Ariel S., Wec, Anna Z., Fels, J. Maximilian, Johndrow, Christopher T., Saunders, Kevin O., Liao, Hua-Xin, Chan, John, Jacobs, William R., Chandran, Kartik, Porcelli, Steven A.

“…The continuing emergence of viral pathogens and their rapid spread into heavily populated areas around the world underscore the urgency for development of…”
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Longitudinally monitored immune biomarkers predict the timing of COVID-19 outcomes by Lasso, Gorka, Khan, Saad, Allen, Stephanie A, Mariano, Margarette, Florez, Catalina, Orner, Erika P, Quiroz, Jose A, Quevedo, Gregory, Massimi, Aldo, Hegde, Aditi, Wirchnianski, Ariel S, Bortz, 3rd, Robert H, Malonis, Ryan J, Georgiev, George I, Tong, Karen, Herrera, Natalia G, Morano, Nicholas C, Garforth, Scott J, Malaviya, Avinash, Khokhar, Ahmed, Laudermilch, Ethan, Dieterle, M Eugenia, Fels, J Maximilian, Haslwanter, Denise, Jangra, Rohit K, Barnhill, Jason, Almo, Steven C, Chandran, Kartik, Lai, Jonathan R, Kelly, Libusha, Daily, Johanna P, Vergnolle, Olivia

“…The clinical outcome of SARS-CoV-2 infection varies widely between individuals. Machine learning models can support decision making in healthcare by assessing…”
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A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants by Haslwanter, Denise, Dieterle, M Eugenia, Wec, Anna Z, O'Brien, Cecilia M, Sakharkar, Mrunal, Florez, Catalina, Tong, Karen, Rappazzo, C Garrett, Lasso, Gorka, Vergnolle, Olivia, Wirchnianski, Ariel S, Bortz, 3rd, Robert H, Laudermilch, Ethan, Fels, J Maximilian, Mengotto, Amanda, Malonis, Ryan J, Georgiev, George I, Quiroz, Jose A, Wrapp, Daniel, Wang, Nianshuang, Dye, Kathryn E, Barnhill, Jason, Dye, John M, McLellan, Jason S, Daily, Johanna P, Lai, Jonathan R, Herbert, Andrew S, Walker, Laura M, Chandran, Kartik, Jangra, Rohit K

“…Most known SARS-CoV-2 neutralizing antibodies (nAbs), including those approved by the FDA for emergency use, inhibit viral infection by targeting the…”
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Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis by Herrera, Natalia G, Morano, Nicholas C, Celikgil, Alev, Georgiev, George I, Malonis, Ryan J, Lee, James H, Tong, Karen, Vergnolle, Olivia, Massimi, Aldo B, Yen, Laura Y, Noble, Alex J, Kopylov, Mykhailo, Bonanno, Jeffrey B, Garrett-Thomson, Sarah C, Hayes, David B, Bortz, 3rd, Robert H, Wirchnianski, Ariel S, Florez, Catalina, Laudermilch, Ethan, Haslwanter, Denise, Fels, J Maximilian, Dieterle, M Eugenia, Jangra, Rohit K, Barnhill, Jason, Mengotto, Amanda, Kimmel, Duncan, Daily, Johanna P, Pirofski, Liise-Anne, Chandran, Kartik, Brenowitz, Michael, Garforth, Scott J, Eng, Edward T, Lai, Jonathan R, Almo, Steven C

“…Coronavirus disease 2019 (COVID-19) is a global health crisis caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and there is a…”
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Neutralizing Antibodies against Crimean–Congo Hemorrhagic Fever Virus Derived from a Human Survivor by J. Maximilian Fels, Daniel Maurer, Ana I. Kuehne, Dafna M. Abelson, Noel T. Pauli, Andrew S. Herbert, John M. Dye, Robert W. Cross, Thomas W. Geisbert, Leslie Lobel, Zachary A. Bornholdt, Laura M. Walker, Kartik Chandran

“…Crimean–Congo hemorrhagic fever virus (CCHFV) is an arbovirus belonging to the Nairoviridae family. The virus, as well as ticks of the Hyalomma genus, which…”
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