Search Results - "Felmeister, Alex"

A longitudinal footprint of genetic epilepsies using automated electronic medical record interpretation by Ganesan, Shiva, Galer, Peter D., Helbig, Katherine L., McKeown, Sarah E., O’Brien, Margaret, Gonzalez, Alexander K., Felmeister, Alex S., Khankhanian, Pouya, Ellis, Colin A., Helbig, Ingo

“…Purpose Childhood epilepsies have a strong genetic contribution, but the disease trajectory for many genetic etiologies remains unknown. Electronic medical…”
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Phenotypic homogeneity in childhood epilepsies evolves in gene-specific patterns across 3251 patient-years of clinical data by Lewis-Smith, David, Ganesan, Shiva, Galer, Peter D, Helbig, Katherine L, McKeown, Sarah E, O'Brien, Margaret, Khankhanian, Pouya, Kaufman, Michael C, Gonzalez, Alexander K, Felmeister, Alex S, Krause, Roland, Ellis, Colin A, Helbig, Ingo

“…While genetic studies of epilepsies can be performed in thousands of individuals, phenotyping remains a manual, non-scalable task. A particular challenge is…”
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The biorepository portal toolkit: an honest brokered, modular service oriented software tool set for biospecimen-driven translational research by Felmeister, Alex S, Masino, Aaron J, Rivera, Tyler J, Resnick, Adam C, Pennington, Jeffrey W

“…High throughput molecular sequencing and increased biospecimen variety have introduced significant informatics challenges for research biorepository…”
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Correction: A longitudinal footprint of genetic epilepsies using automated electronic medical record interpretation by Ganesan, Shiva, Galer, Peter D., Helbig, Katherine L., McKeown, Sarah E., O’Brien, Margaret, Gonzalez, Alexander K., Felmeister, Alex S., Khankhanian, Pouya, Ellis, Colin A., Helbig, Ingo

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A-rearranged leukemia by Chen, Changya, Yu, Wenbao, Alikarami, Fatemeh, Qiu, Qi, Chen, Chia-hui, Flournoy, Jennifer, Gao, Peng, Uzun, Yasin, Fang, Li, Davenport, James W., Hu, Yuxuan, Zhu, Qin, Wang, Kai, Libbrecht, Clara, Felmeister, Alex, Rozich, Isaiah, Ding, Yang-yang, Hunger, Stephen P., Felix, Carolyn A., Wu, Hao, Brown, Patrick A., Guest, Erin M., Barrett, David M., Bernt, Kathrin M., Tan, Kai

“…KMT2A-rearranged (KMT2A-r) infant acute lymphoblastic leukemia (ALL) is a devastating malignancy with a dismal outcome, and younger age at diagnosis is…”
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Single-Cell Multiomics Reveals Increased Plasticity, Resistant Populations and Stem-Cell-like Blasts in KMT2A-Rearranged Leukemia by Chen, Changya, Yu, Wenbao, Alikarami, Fatemeh, Qiu, Qi, Chen, Chia-hui, Flournoy, Jennifer, Gao, Peng, Uzun, Yasin, Fang, Li, Hu, Yuxuan, Zhu, Qin, Wang, Kai, Libbrecht, Clara, Felmeister, Alex, Rozich, Isaiah, Ding, Yang-yang, Hunger, Stephen P, Wu, Hao, Brown, Patrick A., Guest, Erin, Barrett, David M, Bernt, Kathrin M., Tan, Kai

“…KMT2A-rearranged (KMT2A-r) infant ALL is a devastating malignancy with a dismal outcome, and younger age at diagnosis is associated with increased risk of…”
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Pediatric high-grade glioma resources from the Children’s Brain Tumor Tissue Consortium by Ijaz, Heba, Koptyra, Mateusz, Gaonkar, Krutika S, Rokita, Jo Lynne, Baubet, Valerie P, Tauhid, Lamiya, Zhu, Yuankun, Brown, Miguel, Lopez, Gonzalo, Zhang, Bo, Diskin, Sharon J, Vaksman, Zalman, Mason, Jennifer L, Appert, Elizabeth, Lilly, Jena, Lulla, Rishi, De Raedt, Thomas, Heath, Allison P, Felmeister, Alex, Raman, Pichai, Nazarian, Javad, Santi, Maria Rita, Storm, Phillip B, Resnick, Adam, Waanders, Angela J, Cole, Kristina A

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DIPG-51. BLACKFYNN: A SECURE, CLOUD-BASED PLATFORM FOR SHARING AND ANALYZING RESEARCH READY DATA FOR PEDIATRIC CNS CANCERS by Johnson, Courtney, Christini, Amanda, Felmeister, Alex, Baglieri, Chris, Kambhampati, Madhuri, Waanders, Angela, Mason, Jennifer, Packer, Roger, Resnick, Adam, Nazarian, Javad

“…Abstract INTRODUCTION Sharing research ready data between multiple institutions and across different platforms is a lengthy and cumbersome process which can…”
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Scalable biobanking: A modular electronic Honest Broker and Biorepository for integrated clinical, specimen and genomic research by Felmeister, Alex S., Rivera, Tyler J., Masino, Aaron J., Resnick, Adam C., Pennington, Jeffrey W.

“…Biorepository research has introduced significant challenges to biomedical informatics systems design and implementation. We take a best-of-breed system…”
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Abstract 3667: The Pediatric Brain Tumor Atlas - Transforming the landscape of research by Zhu, Yuankun, Guo, Yiran, Heath, Allison P., Raman, Pichai, Appert, Elizabeth, Mason, Jennifer, Zhang, Bo, Kalletla, Karthik, Brown, Miguel A., Singh, Natasha, Farrow, Bailey K., Killada, Parimala, Kim, Meen Chul, Felmeister, Alex, Koptyra, Mateusz P., Mueller, Sabine, Prados, Michael, Lilly, Jena V., Lulla, Rishi, Resnick, Adam C., Nazarian, Javad, Storm, Phillip B., Waanders, Angela J.

“…Abstract The Pediatric Brain Tumor Atlas (PBTA) is a cloud-based, cross-platform, and data-rich collaborative effort to accelerate discoveries for therapeutic…”
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GENE-12. THE CHILDREN’S BRAIN TUMOR TISSUE CONSORTIUM (CBTTC) INFRASTRUCTURE FACILITATES COLLABORATIVE RESEARCH IN PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS by Felmeister, Alex, Lulla, Rishi, Waanders, Angela, Raman, Pichai, Santi, Mariarita, Lilly, Jena, Mason, Jennifer, Nazarian, Javad, Resnick, Adam

“…INTRODUCTION: The Children’s Brain Tumor Tissue Consortium (CBTTC) is a multi-institutional, international research collaboration comprised of 13 institutions…”
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Abstract LB-008: The Pediatric Brain Tumor Atlas: building an integrated, multi-platform data-rich ecosystem for collaborative discovery in the cloud by Resnick, Adam C., Storm, Phillip B., Waanders, Angela J., Lilly, Jena V., Lulla, Rishi R., Mueller, Sabine, Prados, Michael, Sender, Leonard S., Heath, Allison, Felmeister, Alex S., Cros, Anthony, Zhu, Yuankun, Raman, Pichai

“…Abstract Pediatric brain tumors are the leading cause of disease-related death in children. However, despite large scale data-driven efforts for pediatric…”
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Abstract 2593: Accelerating pediatric brain tumor research through team science solutions by Christini, Amanda, Waanders, Angela J., Wagenaar, Joost B., Felmeister, Alex S., Santi, Mariarita, Wadhwani, Nitin R., Mason, Jennifer L., Koptyra, Mateusz P., Lilly, Jena V., Pennington, Jeffrey W., Lulla, Rishi R., Resnick, Adam C.

“…Abstract Introduction: The Children’s Brain Tumor Tissue Consortium (CBTTC), an international repository of genomic and phenotypic data, has partnered with…”
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PDTM-16. PEDIATRIC HIGH GRADE GLIOMA RESOURCES FROM THE CHILDREN’S BRAIN TUMOR TISSUE CONSORTIUM (CBTTC) AND PEDIATRIC BRAIN TUMOR ATLAS (PBTA) by Ijaz, Heba, Koptyra, Mateusz, Gaonkar, Krutika, Lynne Rokita, Jo, Baubet, Valerie, Tauhid, Lamiya, Zhu, Yuankun, Brown, Miguel, Lopez, Gonzalo, Zhang, Bo, Diskin, Sharon, Vaksman, Zalman, Mason, Jennifer, Appert, Elizabeth, Lilly, Jena, Lulla, Rishi, De Raedt, Thomas, Heath, Allison, Felmeister, Alex, Raman, Pichai, Nazarian, Javad, Santi, Mariarita, Storm, Phillip, Resnick, Adam, Waanders, Angela, Cole, Kristina

“…Abstract BACKGROUND Pediatric high grade glioma (pHGG) remains a fatal disease. Access to richly annotated biospecimens and patient derived tumor models will…”
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A Unified Framework for Collecting, Annotating, Modeling and Prediction from Phenotypes in Multi-Institutional Pediatric Data Resources by Felmeister, Alex S

“…Predictive models on sequential observational clinical data have helped make headway utilizing large sets of this data collected from health systems from…”
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TMOD-20. THE PEDIATRIC BRAIN TUMOR ATLAS: AN INITIATIVE BY THE CHILDREN’S BRAIN TUMOR TISSUE CONSORTIUM AND PACIFIC PEDIATRIC NEUROONCOLOGY CONSORTIUM by Zhu, Yuankun, Guo, Yiran, Heath, Allison, Raman, Pichai, Appert, Elizabeth, Mason, Jennifer, Zhang, Bo, Kalletla, Karthik, Brown, Miguel, Singh, Natasha, Farrow, Bailey, Felmeister, Alex, Killada, Parimala, Kim, Meen Chul, Lilly, Jena, Koptyra, Mateusz, Lulla, Rishi, Mueller, Sabine, Prados, Michael, Resnick, Adam, Nazarian, Javad, Storm, Phillip, Waanders, Angela

“…Abstract The Pediatric Brain Tumor Atlas (PBTA), created as a multi-center effort by the Children’s Brain Tumor Tissue Consortium (CBTTC) and Pacific Pediatric…”
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GENE-15. CAVATICA- A PEDIATRIC GENOMIC CLOUD EMPOWERING DATA DISCOVERY THROUGH THE PEDIATRIC BRAIN TUMOR ATLAS by Raman, Pichai, Waanders, Angela J, Storm, Phillip B, Lilly, Jena V, Mason, Jennifer, Heath, Allison P, Felmeister, Alex S, Cros, Anthony, Zhu, Yuankun, Sender, Leonard, Prados, Michael, Mueller, Sabine, Lulla, Rishi, Nazarian, Javad, Resnick, Adam C

“…CAVATICA (cavatica.org) was developed to address the lack of open access large scale pediatric cancer genomic datasets for the research community. As the first…”
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DIPG-51. BLACKFYNN: A SECURE, CLOUD-BASED PLATFORM FOR SHARING AND ANALYZING RESEARCH READY DATA FOR PEDIATRIC CNS CANCERS by Johnson, Courtney, Christini, Amanda, Felmeister, Alex, Baglieri, Chris, Kambhampati, Madhuri, Waanders, Angela, Mason, Jennifer, Packer, Roger, Resnick, Adam, Nazarian, Javad

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A Framework for Analysis, Ontological Evaluation, and Visualization in Preparation to Predictive Analytics in Pediatric Brain Tumor Research by Felmeister, Alex S., Waanders, Angela J., Mason, Jennifer L., Stevens, Jeff, Bailey, L. Charles, Ganesan, Shiva, Helbig, Ingo

“…We provide a generalizable framework for the systematic analysis of complicated, longitudinal clinical features in pediatric cancer. We use a threefold…”
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Preliminary exploratory data analysis of simulated national clinical data research network for future use in annotation of a rare tumor biobanking initiative by Felmeister, Alex S., Waanders, Angela J., Leary, Sarah E. S., Stevens, Jeff, Mason, Jennifer L., Teneralli, Rachel, Xiaohua Hu, Bailey, L. Charles

“…Observational data resources based on the capture of clinical data in the electronic health record (EHR) have produced significant learning opportunities in…”
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