Search Results - "Fellows, D"

Enhanced Nanoparticle Size Control by Extending LaMer’s Mechanism by Vreeland, Erika C, Watt, John, Schober, Gretchen B, Hance, Bradley G, Austin, Mariah J, Price, Andrew D, Fellows, Benjamin D, Monson, Todd C, Hudak, Nicholas S, Maldonado-Camargo, Lorena, Bohorquez, Ana C, Rinaldi, Carlos, Huber, Dale L

“…The synthesis of well-defined nanoparticle materials has been an area of intense investigation, but size control in nanoparticle syntheses is largely…”
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Precision digital mapping of endogenous and induced genomic DNA breaks by INDUCE-seq by Dobbs, Felix M., van Eijk, Patrick, Fellows, Mick D., Loiacono, Luisa, Nitsch, Roberto, Reed, Simon H.

“…Understanding how breaks form and are repaired in the genome depends on the accurate measurement of the frequency and position of DNA double strand breaks…”
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Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS by Gibbs, Katherine L., Kalmar, Bernadett, Rhymes, Elena R., Fellows, Alexander D., Ahmed, Mahmood, Whiting, Paul, Davies, Ceri H., Greensmith, Linda, Schiavo, Giampietro

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the degeneration of upper and lower motor neurons. Defects in axonal…”
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Superferromagnetic Nanoparticles Enable Order‐of‐Magnitude Resolution & Sensitivity Gain in Magnetic Particle Imaging by Tay, Zhi Wei, Savliwala, Shehaab, Hensley, Daniel W., Fung, K.L. Barry, Colson, Caylin, Fellows, Benjamin D., Zhou, Xinyi, Huynh, Quincy, Lu, Yao, Zheng, Bo, Chandrasekharan, Prashant, Rivera‐Jimenez, Sindia M., Rinaldi‐Ramos, Carlos M., Conolly, Steven M.

“…Magnetic nanoparticles have many advantages in medicine such as their use in non‐invasive imaging as a Magnetic Particle Imaging (MPI) tracer or Magnetic…”
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Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons by Rhymes, Elena R., Tosolini, Andrew P., Fellows, Alexander D., Mahy, William, McDonald, Neil Q., Schiavo, Giampietro

“…Deficits in axonal transport are one of the earliest pathological outcomes in several models of amyotrophic lateral sclerosis (ALS), including SOD1 G93A mice…”
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Cell division in Apicomplexan parasites is organized by a homolog of the striated rootlet fiber of algal flagella by Francia, Maria E, Jordan, Carly N, Patel, Jay D, Sheiner, Lilach, Demerly, Jessica L, Fellows, Justin D, de Leon, Jessica Cruz, Morrissette, Naomi S, Dubremetz, Jean-François, Striepen, Boris

“…Apicomplexa are intracellular parasites that cause important human diseases including malaria and toxoplasmosis. During host cell infection new parasites are…”
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Momentary work worries, marital disclosure, and salivary cortisol among parents of young children by Slatcher, Richard B, Robles, Theodore F, Repetti, Rena L, Fellows, Michelle D

“…To investigate whether worries about work are linked to people's own cortisol levels and their spouses' cortisol levels in everyday life and whether marital…”
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A cross-industry survey on photosafety evaluation of pharmaceuticals after implementation of ICH S10 by Bauer, Daniel, Buckley, Lorrene A., Delafoy, Laure, Ellinger-Ziegelbauer, Heidrun, Fellows, Mick D., Gerets, Helga H.J., Howe, Jonathan, Kaijser, Gerry, Nicolette, John, Pettersen, Betty A., Schimpf, Brian

“…A cross-industry survey was conducted by EFPIA/IQ DruSafe in 2018 to provide information on photosafety evaluation of pharmaceuticals after implementation of…”
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Cone beam CT analysis of Haller cells: prevalence and clinical significance by Mathew, R, Omami, G, Hand, A, Fellows, D, Lurie, A

“…Haller cells are anterior ethmoid air cells located in the medial orbital floor immediately lateral to the maxillary infundibulum. The purpose of this study…”
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The iron-sulfur scaffold protein HCF101 unveils the complexity of organellar evolution in SAR, Haptista and Cryptista by Pyrih, Jan, Žárský, Vojtěch, Fellows, Justin D, Grosche, Christopher, Wloga, Dorota, Striepen, Boris, Maier, Uwe G, Tachezy, Jan

“…Nbp35-like proteins (Nbp35, Cfd1, HCF101, Ind1, and AbpC) are P-loop NTPases that serve as components of iron-sulfur cluster (FeS) assembly machineries. In…”
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Re-evaluation of the Mutagenic Response to Phosphorothioate Nucleotides in Human Lymphoblastoid TK6 Cells by Saleh, Amer F, Priestley, Catherine C, Gooderham, Nigel J, Fellows, Mick D

“…The degradation of phosphorothioate oligonucleotides (PS-ONDs) and the release of potentially genotoxic modified mononucleotides raise a safety concern for…”
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Standardized cell sources and recommendations for good cell culture practices in genotoxicity testing by Lorge, E., Moore, M.M., Clements, J., O’Donovan, M., Fellows, M.D., Honma, M., Kohara, A., Galloway, S., Armstrong, M.J., Thybaud, V., Gollapudi, B., Aardema, M.J., Tanir, J.Y.

“…•Good cell culture practice is critical in in vitro genotoxicity testing.•This initiative made stocks of mammalian cell lines available worldwide.•Cell lines…”
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Axonal transport and neurological disease by Sleigh, James N., Rossor, Alexander M., Fellows, Alexander D., Tosolini, Andrew P., Schiavo, Giampietro

“…Axonal transport is the process whereby motor proteins actively navigate microtubules to deliver diverse cargoes, such as organelles, from one end of the axon…”
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Cytotoxicity in cultured mammalian cells is a function of the method used to estimate it by Fellows, Michael D., O'Donovan, Michael R.

“…Up to prescribed limits, the maximum test compound concentrations used in mammalian cell genotoxicity assays in vitro are determined by cytotoxicity, unless…”
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Etoposide, cadmium chloride, benzo[a]pyrene, cyclophosphamide and colchicine tested in the in vitro mammalian cell micronucleus test (MNvit) in the presence and absence of cytokinesis block using L5178Y mouse lymphoma cells and 2-aminoanthracene tested in MNvit in the absence of cytokinesis block using TK6 cells at AstraZeneca UK, in support of OECD draft Test Guideline 487 by Fellows, Michael D., O’Donovan, Michael R.

“…At the laboratories of AstraZeneca, Alderley Park, UK the reference genotoxic agents etoposide (a topoisomerase II inhibitor), cadmium chloride (an inorganic…”
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Large and Small Dendritic Spines Serve Different Interacting Functions in Hippocampal Synaptic Plasticity and Homeostasis by Edwards, Frances A., Joel, Zelah, Jackson, Joshua D., Liu, Wenfei, Fellows, Alexander D., Haslehurst, Peter, Paulin, Joshua J. W., Cummings, Damian M.

“…The laying down of memory requires strong stimulation resulting in specific changes in synaptic strength and corresponding changes in size of dendritic spines…”
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Duplication of clostridial binding domains for enhanced macromolecular delivery into neurons by Leese, Charlotte, Bresnahan, Rebecca, Doran, Ciara, Simsek, Deniz, Fellows, Alexander D., Restani, Laura, Caleo, Matteo, Schiavo, Giampietro, Mavlyutov, Timur, Henke, Tina, Binz, Thomas, Davletov, Bazbek

“…Neurological diseases constitute a quarter of global disease burden and are expected to rise worldwide with the ageing of human populations. There is an…”
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In vivo CRISPR editing with no detectable genome-wide off-target mutations by Akcakaya, Pinar, Bobbin, Maggie L., Guo, Jimmy A., Malagon-Lopez, Jose, Clement, Kendell, Garcia, Sara P., Fellows, Mick D., Porritt, Michelle J., Firth, Mike A., Carreras, Alba, Baccega, Tania, Seeliger, Frank, Bjursell, Mikael, Tsai, Shengdar Q., Nguyen, Nhu T., Nitsch, Roberto, Mayr, Lorenz M., Pinello, Luca, Bohlooly-Y, Mohammad, Aryee, Martin J., Maresca, Marcello, Joung, J. Keith

“…CRISPR–Cas genome-editing nucleases hold substantial promise for developing human therapeutic applications 1 – 6 but identifying unwanted off-target mutations…”
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The incidence of positive results in the mouse lymphoma TK assay (MLA) in pharmaceutical screening and their prediction by MultiCase MC4PC by Fellows, Michael D., Boyer, Scott, O'Donovan, Michael R.

“…There are published data indicating that the mouse lymphoma TK assay (MLA) has an unacceptably high incidence of positive results, hence it was decided to…”
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The ability of the mouse lymphoma TK assay to detect aneugens by Fellows, Michael D., Doherty, Ann T., Priestley, Catherine C., Howarth, Victoria, O'Donovan, Michael R.

“…There is some evidence that the mouse lymphoma TK assay (MLA) can detect aneugens, and this is accepted in the current International Conference on…”
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