Search Results - "Felkins, Kathleen"

Cladribine transfer into human milk: A case report by Datta, Palika, Ciplea, Andrea I, Rewers-Felkins, Kathleen, Baker, Teresa, Gold, Ralf, Hale, Thomas W, Hellwig, Kerstin

“…Background: Cladribine is an antimetabolite used for the treatment of relapsing–remitting multiple sclerosis. At present, there are no data available on its…”
Get full text

Pharmacokinetics of a single dose of oclacitinib maleate as a top dress in adult horses by Hunyadi, Laszlo, Datta, Palika, Rewers‐Felkins, Kathleen, Sundman, Emily, Hale, Thomas, Fajt, Virginia, Wagner, Sarah

“…The objective of this study was to determine the pharmacokinetic parameters of oclacitinib maleate as a top dress given to adult horses. Six adult horses with…”
Get full text

Dimethyl fumarate transfer into human milk by Ciplea, Andrea I., Datta, Palika, Rewers-Felkins, Kathleen, Baker, Teresa, Gold, Ralf, Hale, Thomas W., Hellwig, Kerstin

“…Dimethyl fumarate (DMF) is approved for the treatment of relapsing-remitting multiple sclerosis. It is unknown whether DMF or its primary metabolite monomethyl…”
Get full text

Immunotherapy with IL-10- and IFN-γ-producing CD4 effector cells modulate “Natural” and “Inducible” CD4 TReg cell subpopulation levels: observations in four cases of patients with ovarian cancer by Dobrzanski, Mark J., Rewers-Felkins, Kathleen A., Samad, Khaliquzzaman A., Quinlin, Imelda S., Phillips, Catherine A., Robinson, William, Dobrzanski, David J., Wright, Stephen E.

“…Adoptive T cell therapy for cancer patients optimally requires participation of CD4 T cells. In this phase I/II study, we assessed the therapeutic effects of…”
Get full text

Human Milk Endocannabinoid Levels as a Function of Obesity and Diurnal Rhythm by Datta, Palika, Melkus, Michael W, Rewers-Felkins, Kathleen, Patel, Dhavalkumar, Bateman, Tiffany, Baker, Teresa, Hale, Thomas W

“…The endocannabinoid system is involved in the regulation of a variety of physiological and cognitive processes. While the endocannabinoids…”
Get full text

Cytotoxic T-lymphocyte Immunotherapy for Ovarian Cancer: A Pilot Study by WRIGHT, Stephen E, REWERS-FELKINS, Kathleen A, QUINLIN, Imelda S, PHILLIPS, Catherine A, TOWNSEND, Mary, PHILIP, Ramila, DOBRZANSKI, Mark J, LOCKWOOD-COOKE, Pamela R, ROBINSON, William

“…The objective was to evaluate the toxicity and feasibility of intraperitoneal infusion of tumor-specific cytotoxic T lymphocytes (CTL) as therapy for recurrent…”
Get full text

CD8-Mediated Type 1 Antitumor Responses Selectively Modulate Endogenous Differentiated and Nondifferentiated T Cell Localization, Activation, and Function in Progressive Breast Cancer by Dobrzanski, Mark J, Reome, Joyce B, Hylind, James C, Rewers-Felkins, Kathleen A

“…CD8 T cell-mediated immune responses fall into two distinct types based on effector cell-derived cytokine production. Type I CD8 T cells (Tc1) produce…”
Get full text

Costimulation with anti-cluster of differentiation 3 and anti-cluster of differentiation 28 reduces the activity of mucin 1-stimulated human mononuclear cells by WRIGHT, STEPHEN E, REWERS-FELKINS, KATHLEEN A, QUINLIN, IMELDA, ZOHRA, FATEMA, AHMED, JEWEL

“…Cytotoxic T-lymphocyte activation and extension of the cell life span is necessary in order to enable immunotherapy to perform effectively against cancer. In…”
Get full text

Autologous MUC1-specific Th1 effector cell immunotherapy induces differential levels of systemic TReg cell subpopulations that result in increased ovarian cancer patient survival by Dobrzanski, Mark J, Rewers-Felkins, Kathleen A, Quinlin, Imelda S, Samad, Khaliquzzaman A, Phillips, Catherine A, Robinson, William, Dobrzanski, David J, Wright, Stephen E

“…Abstract Adoptive T cell immunotherapy using autologous lymphocytes is a viable treatment for patients with cancer and requires participation of Ag-specific…”
Get full text

Targeting Migration inducting gene-7 inhibits carcinoma cell invasion, early primary tumor growth, and stimulates monocyte oncolytic activity by Petty, Aaron P, Wright, Stephen E, Rewers-Felkins, Kathleen A, Yenderrozos, Michelle A, Vorderstrasse, Beth A, Lindsey, J Suzanne

“…Expression of Migration inducting gene-7 (Mig-7) is limited to tumor cells and to date not found in normal tissues. Multiple tumor microenvironment factors,…”
Get full text

Dendritic cells enhance the activity of human MUC1-stimulated mononuclear cells against breast cancer by Wang, Zhenyao, Hall, Monte D., Rewers-Felkins, Kathleen A., Quinlin, Imelda S., Wright, Stephen E.

“…Dendritic cells (DCs) are among the most potent antigen-presenting cells (APCs), stimulating peripheral blood mononuclear cells (PBMCs) to generate…”
Get full text

Tucaresol down-modulation of MUC1-stimulated human mononuclear cells by Wright, Stephen E., Rewers-Felkins, Kathleen A., Chowdhury, Nazrul I., Ahmed, Jewel, Srivastava, Sanjay K., Lockwood-Cooke, Pamela R.

“…Interaction between antigen presenting cells and T lymphocytes, through receptors and co-stimulatory molecules present on the surface of these cells, is one of…”
Get full text

TGFα-PE38 enhances cytotoxic T-lymphocyte killing of breast cancer cells by WRIGHT, STEPHEN E, REWERS-FELKINS, KATHLEEN A, QUINLIN, IMELDA, CHOWDHURY, NAZRUL I, AHMED, JEWEL, ELDRIDGE, PAUL W, SRIVASTAVA, SANJAY K, PASTAN, IRA

“…The aim of the present study was to determine whether the combination of two modalities of immunotherapy, targeting two different tumor antigens, may be…”
Get full text

Prevention of human adenocarcinoma with CpG-ODN in a mouse model by WRIGHT, STEPHEN E, REWERS-FELKINS, KATHLEEN A, CHOWDHURY, NAZRUL I, AHMED, JEWEL, SRIVASTAVA, SANJAY K

“…CpG-ODNs activate various immune cell subsets and induce the production of numerous cytokines. To determine whether a CpG-ODN-activated innate immune system,…”
Get full text

Ag-specific type 1 CD8 effector cells enhance methotrexate-mediated antitumor responses by modulating differentiated T cell localization, activation and chemokine production in established breast cancer by Dobrzanski, Mark J, Reome, Joyce B, Hylind, James C, Rewers-Felkins, Kathleen A, Abulsamad, Khaliquzzaman, Adams, Shawna L

“…Abstract The chemotherapeutic agent methotrexate is widely used in the treatment of breast cancer. Although its mechanism-of-action has been defined, less is…”
Get full text

Tumor Burden Influences Cytotoxic T Cell Development in Metastatic Breast Cancer Patients-A Phase I II Study by Wright, Stephen E., Rewers-Felkins, Kathleen A., Quinlin, Imelda S., Phillips, Catherine A., Townsend, Mary, Philip, Ramila, Zorsky, Paul, Klug, Panpit, Dai, Lijun, Hussain, Mohammad, Thomas, Aabu A., Sundaramurthy, Chithraleka

“…The influence of tumor burden on the generation of tumor antigen-specific cytotoxic T-lymphocytes (CTL) was investigated in a phase I II clinical adoptive…”
Get full text

MHC-Unrestricted Lysis of MUC1-Expressing Cells by Human Peripheral Blood Mononuclear Cells by Wright, Stephen E., Rewers-Felkins, Kathleen A., Quinlin, Imelda S., Fogler, William E., Phillips, Catherine A., Townsend, Mary, Robinson, William, Philip, Ramila

“…Many human adenocarcinomas can be killed in vitro by targeted cytotoxic T-lymphocytes (CTL); however, major histocompatibility complex (MHC)-restrictions are…”
Get full text

Number of Treatment Cycles Influences Development of Cytotoxic T Cells in Metastatic Breast Cancer Patients - A Phase I II Study by Wright, Stephen E., Rewers-Felkins, Kathleen A., Quinlin, Imelda S., Phillips, Catherine A., Townsend, Mary, Philip, Ramila, Zorsky, Paul, Klug, Panpit, Dai, Lijun, Hussain, Mohammad, Thomas, Aabu A., Sundaramurthy, Chithraleka

“…The influence of the number of apheresis-stimulation-infusion(s) cycles, and the time in culture before the infusion (one vs. two weeks), on the generation of…”
Get full text

Ag-Specific Type 1 CD8 Effector Cells Enhance Methotrexate-Mediated Antitumor Responses by Modulating Endogenous CD49b-Expressing CD4 and CD8 T Effector Cell Subpopulations Producing IL-10 by Dobrzanski, Mark J., Reome, Joyce B., Hylind, James C., Rewers-Felkins, Kathleen A., Abdulsamad, Khaliquzzaman, Adams, Shawna L.

“…The chemotherapeutic agent methotrexate is widely used in the treatment of breast cancer. Although its mechanism-of-action has been defined, less is known…”
Get full text

Transfer of Inhaled Cannabis Into Human Breast Milk by Baker, Teresa, Datta, Palika, Rewers-Felkins, Kathleen, Thompson, Heather, Kallem, Raja R., Hale, Thomas W.

“…OBJECTIVE:To evaluate the transfer of delta-9-tetrahydrocannabinol and its metabolites into human breast milk after maternal inhalation of 0.1 g cannabis…”
Get full text