Search Results - "Felix A. Urra"

TNF-Alpha Promotes an Inflammatory Mammary Microenvironment That Favors Macrophage and Epithelial Migration in a CCL2- and Mitochondrial-ROS-Dependent Manner by Vera, María Jesús, Guajardo, Francisco, Urra, Felix A, Tobar, Nicolás, Martínez, Jorge

“…The influence of an inflammatory microenvironment on tumorigenesis has been widely accepted. Systemic conditions that favor the onset of an inflammatory…”
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Two new species of the Liolaemus elongatus-kriegi complex (Iguania, Liolaemidae) from Andean highlands of southern Chile by Troncoso-Palacios, Jaime, Díaz, Hugo A, Esquerré, Damien, Urra, Felix A

“…The elongatus -kriegi complex is one of the most diverse clades of the Liolaemus (sensu stricto ) subgenus of lizards. There are currently 29 species…”
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Regulation of mitochondrial function as a promising target in platelet activation-related diseases by Fuentes, Eduardo, Araya-Maturana, Ramiro, Urra, Félix A.

“…Platelets are anucleated cell elements produced by fragmentation of the cytoplasm of megakaryocytes and have a unique metabolic phenotype compared with…”
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Putting the brakes on tumorigenesis with snake venom toxins: New molecular insights for cancer drug discovery by Urra, Félix A., Araya-Maturana, Ramiro

“…Cancer cells exhibit molecular characteristics that confer them different proliferative capacities and survival advantages to adapt to stress conditions, such…”
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The Mitochondrial Complex(I)ty of Cancer by Urra, Félix A, Muñoz, Felipe, Lovy, Alenka, Cárdenas, César

“…Recent evidence highlights that the cancer cell energy requirements vary greatly from normal cells and that cancer cells exhibit different metabolic phenotypes…”
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Altered dynamics of calcium fluxes and mitochondrial metabolism in platelet activation-related disease and aging by Arauna, Diego, Araya-Maturana, Ramiro, Urra, Félix A., García, Ángel, Palomo, Iván, Fuentes, Eduardo

“…Understanding the mechanisms controlling platelet function is crucial for exploring potential therapeutic targets related to atherothrombotic pathologies and…”
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Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura: Bufonidae) by Schmeda-Hirschmann, Guillermo, Quispe, Cristina, Arana, Gabriel Vargas, Theoduloz, Cristina, Urra, Félix A., Cárdenas, César

“…Little is known on the composition of Peruvian Amazon toad venoms. The large toad Rhinella marina is common in the cleared tropical forests of the Iquitos…”
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Targeting Metastasis with Snake Toxins: Molecular Mechanisms by Urra, Félix A, Araya-Maturana, Ramiro

“…Metastasis involves the migration of cancer cells from a primary tumor to invade and establish secondary tumors in distant organs, and it is the main cause for…”
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Mitochondrial bioenergetics as a cell fate rheostat for responsive to Bcl-2 drugs: New cues for cancer chemotherapy by Palominos, Charlotte, Fuentes-Retamal, Sebastián, Salazar, Juan Pablo, Guzmán-Rivera, Daniela, Correa, Pablo, Mellado, Mathias, Araya-Maturana, Ramiro, Urra, Félix A.

“…Pro-survival BCL-2 proteins prevent the initiation of intrinsic apoptosis (mitochondria-dependent pathway) by inhibiting the pro-apoptotic proteins BAX and…”
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Identification of Antioxidant Methyl Derivatives of Ortho -Carbonyl Hydroquinones That Reduce Caco-2 Cell Energetic Metabolism and Alpha-Glucosidase Activity by Monroy-Cárdenas, Matías, Almarza, Cristopher, Valenzuela-Hormazábal, Paulina, Ramírez, David, Urra, Félix A, Martínez-Cifuentes, Maximiliano, Araya-Maturana, Ramiro

“…α-glucosidase, a pharmacological target for type 2 diabetes mellitus (T2DM), is present in the intestinal brush border membrane and catalyzes the hydrolysis of…”
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The role of cholesterol and mitochondrial bioenergetics in activation of the inflammasome in IBD by Astorga, Jessica, Gasaly, Naschla, Dubois-Camacho, Karen, De la Fuente, Marjorie, Landskron, Glauben, Faber, Klaas Nico, Urra, Félix A, Hermoso, Marcela A

“…Inflammatory Bowel Disease (IBD) is characterized by a loss of intestinal barrier function caused by an aberrant interaction between the immune response and…”
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Assessing mitochondria-targeted acyl hydroquinones on the mitochondrial platelet function and cytotoxic activity: Role of the linker length by Montecino-Garrido, Héctor, Sepúlveda, Magdalena, Méndez, Diego, Monroy-Cárdenas, Matías, Alfaro, Sergio, González-Avendaño, Mariela, Caballero, Julio, Urra, Félix A., Araya-Maturana, Ramiro, Fuentes, Eduardo

“…The use of triphenylphosphonium cation (TPP+) linked to phenolic compounds by alkyl chains has a significant relevance as a mitochondrial delivery strategy in…”
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Simultaneous identification of three clinically relevant peruvian pit vipers by multiplex loop-mediated isothermal amplification (mLAMP) by Agurto-Arteaga, Andres, Vivas-Ruiz, Dan E., Lazo, Fanny, Proleón, Álex, Torrejón, Daniel, Electo, Jorge, Cayo, Carmen, Urra, Felix A., Chávez-Olórtegui, Carlos, Sánchez, Eladio F., Yarlequé, Armando

“…Previous knowledge about the taxonomic distribution of venomous snake species is very useful for epidemiological aspects of ophidism. Here, we sought to…”
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Metabolic energetic adaptation of Atlantic salmon phagocytes to changes in carbon sources and exposure to PAMPs by Ortiz, Daniela, Guajardo, Francisco, Talamilla-Espinoza, Andrea, Vera-Tamargo, Francisca, Pérez-Valenzuela, Javiera, Mejías, Madelaine, Pino-Quezada, Lucas, Galdames-Contreras, Felipe, Mandakovic, Dinka, Wacyk, Jurij, Urra, Félix A., Pulgar, Rodrigo

“…Phagocytic cells are pivotal for host homeostasis and infection defense, necessitating metabolic adaptations in glycolysis, the tricarboxylic acid (TCA) cycle,…”
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An Emergent Role for Mitochondrial Bioenergetics in the Action of Snake Venom Toxins on Cancer Cells by Urra, Félix A., Vivas-Ruiz, Dan E., Sanchez, Eladio Flores, Araya-Maturana, Ramiro

“…Beyond the role of mitochondria in apoptosis initiation/execution, some mitochondrial adaptations support the metastasis and chemoresistance of cancer cells…”
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Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6 by Méndez, Diego, Urra, Félix A., Millas-Vargas, Juan Pablo, Alarcón, Marcelo, Rodríguez-Lavado, Julio, Palomo, Iván, Trostchansky, Andrés, Araya-Maturana, Ramiro, Fuentes, Eduardo

“…Cardiovascular diseases are the leading cause of death in the world. Platelets have a major role in cardiovascular events as they bind to the damaged…”
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Idiopathic inflammatory myopathy human derived cells retain their ability to increase mitochondrial function by Basualto-Alarcón, Carla, Urra, Félix A, Bozán, María Francisca, Jaña, Fabián, Trangulao, Alejandra, Bevilacqua, Jorge A, Cárdenas, J César

“…Idiopathic Inflammatory Myopathies (IIMs) have been studied within the framework of autoimmune diseases where skeletal muscle appears to have a passive role in…”
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First reports of envenoming by South American water snakes Helicops angulatus and Hydrops triangularis from Bolivian Amazon: A one-year prospective study of non-front-fanged colubroid snakebites by Villca-Corani, Huber, Nieto-Ariza, Beatriz, León, Raúl, Rocabado, José A., Chippaux, Jean-Philippe, Urra, Félix A.

“…Although snakebite incidence is underestimated in Bolivia, the Amazon region presents the highest incidence of these accidents. The local effects of bites by…”
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Comparison of Four Methods of RNA Extraction and cDNA Synthesis from The Venom of Peruvian Snakes of the Genus Bothrops of Clinical Importance by Torrejón, Daniel, Cárdenas, Javier, Juárez, Diana, Espinoza, Jordano, Proleón, Alex, Agurto-Arteaga, Andrés, Lazo, Fanny, Leguía, Mariana, Urra, Félix A, Sánchez, Eladio F, Chávez-Olortegui, Carlos, Vivas-Ruiz, Dan E, Yarlequé, Armando

“…RNA purification and cDNA synthesis represents the starting point for molecular analyses of snake venom proteins-enzymes. Usually, the sacrifice of snakes is…”
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The Paraguayan Rhinella toad venom: Implications in the traditional medicine and proliferation of breast cancer cells by Schmeda-Hirschmann, Guillermo, Gomez, Celeste Vega, Rojas de Arias, Antonieta, Burgos-Edwards, Alberto, Alfonso, Jorge, Rolon, Miriam, Brusquetti, Francisco, Netto, Flavia, Urra, Félix A., Cárdenas, César

“…Toads belonging to genus Rhinella are used in Paraguayan traditional medicine to treat cancer and skin infections. The objective of the study was to determine…”
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