Search Results - "Felix, AM"

PRMT7, a New Protein Arginine Methyltransferase That Synthesizes Symmetric Dimethylarginine by Lee, Jin-Hyung, Cook, Jeffry R., Yang, Zhi-Hong, Mirochnitchenko, Olga, Gunderson, Samuel I., Felix, Arthur M., Herth, Nicole, Hoffmann, Ralf, Pestka, Sidney

“…The cDNA for PRMT7, a recently discovered human protein-arginine methyltransferase (PRMT), was cloned and expressed in Escherichia coli and mammalian cells…”
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The Alzheimer's Peptide Aβ Adopts a Collapsed Coil Structure in Water by Zhang, S., Iwata, K., Lachenmann, M.J., Peng, J.W., Li, S., Stimson, E.R., Lu, Y.-a., Felix, A.M., Maggio, J.E., Lee, J.P.

“…Theself-assembly of the soluble peptide Aβ into Alzheimer's disease amyloid is believed to involve a conformational change. Hence the solution conformation of…”
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Point Substitution in the Central Hydrophobic Cluster of a Human β-Amyloid Congener Disrupts Peptide Folding and Abolishes Plaque Competence by Esler, William P, Stimson, Evelyn R, Ghilardi, Joseph R, Lu, Yi-An, Felix, Arthur M, Vinters, Harry V, Mantyh, Patrick W, Lee, Jonathan P, Maggio, John E

“…Alzheimer's disease (AD) is pathologically characterized by the presence of numerous insoluble amyloid plaques in the brain composed primarily of a 40−43 amino…”
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Syntheses and Structural Characterization of a Monomeric Tin(II) Diamide and a Novel Chlorotin(II) Amide Trimer by Tang, Yongjun, Felix, Ana M, Zakharov, Lev N, Rheingold, Arnold L, Kemp, Richard A

“…We have found that addition of a 2:1 ratio of the bulky ligand Li[N(mesityl)(SiMe3)] to SnCl2 yields Sn[N(mesityl)(SiMe3)]2, which is found by X-ray…”
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Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes by Panina-Bordignon, P, Lang, R, van Endert, P M, Benazzi, E, Felix, A M, Pastore, R M, Spinas, G A, Sinigaglia, F

“…Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease that results in the destruction of the pancreatic islet beta cells. Glutamic acid…”
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Syntheses and X-ray crystal structures of monomeric zinc and mercury bis(silylamides) by Tang, Yongjun, Felix, Ana M., Boro, Brian J., Zakharov, Lev N., Rheingold, Arnold L., Kemp, Richard A.

“…Lithium amides Li[N(SiMe 3)(R)] (R = –SiPh 2 t Bu and adamantyl) have been treated with anhydrous ZnCl 2 and HgBr 2 to yield the corresponding homoleptic metal…”
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Activation Barriers to Structural Transition Determine Deposition Rates of Alzheimer's Disease Aβ Amyloid by Esler, William P., Felix, Arthur M., Stimson, Evelyn R., Lachenmann, Marcel J., Ghilardi, Joseph R., Lu, Yi-An, Vinters, Harry V., Mantyh, Patrick W., Lee, Jonathan P., Maggio, John E.

“…Brainamyloid composed of the ≈40-amino-acid human β-amyloid peptide Aβ is integral to Alzheimer's disease pathology. To probe the importance of a…”
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Aβ deposition inhibitor screen using synthetic amyloid by ESLER, W. P, STIMSON, E. R, GHILARDI, J. R, FELIX, A. M, LU, Y.-A, VINTERS, H. V, MANTYH, P. W, MAGGIO, J. E

“…The formation, growth, and maturation of brain amyloid "senile" plaques are essential pathological processes in Alzheimer's disease (AD) and key targets for…”
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Dipeptidylpeptidase IV and trypsin-like enzymatic degradation of human growth hormone-releasing hormone in plasma by Frohman, L A, Downs, T R, Heimer, E P, Felix, A M

“…The plasma enzyme responsible for primary proteolytic cleavage of growth hormone-releasing hormone (GRH) at the 2-3 amino acid bond was characterized. Native…”
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Editorial: Bruce Merrifield at the "Crossroads of Chemistry and Biology" by Barany, George, Felix, Arthur M.

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Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites by Herrington, Deirdre A, Clyde, David F, Losonsky, Genevieve, Cortesia, Manuel, Murphy, James R, Davis, Jonathan, Baqar, Shahida, Felix, Arthur M, Heimer, Edgar P, Gillessen, Dieter, Nardin, Elizabeth, Nussenzweig, Ruth S, Nussenzweig, Victor, Hollingdale, Michael R, Levine, Myron M

“…A 12 amino-acid synthetic peptide (NANP)3 comprising the immunodominant epitope of Plasmodium falciparum circumsporozoite protein was conjugated to tetanus…”
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Rational design, synthesis, and biological evaluation of novel growth hormone releasing factor analogues by Campbell, R M, Bongers, J, Felix, A M

“…Since its initial discovery in 1982, growth hormone-releasing factor (GRF) has been the subject of intense investigation. This interest was prompted by the…”
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Synthesis of bis- and tris-branched COOH-terminal pegylating reagents: conjugation to NH2-terminal peptides by Felix, A.M., Bandaranayake, R.M.

“…:  In previous studies we reported an orthogonal protection scheme that was developed for the solution‐phase synthesis of a family of bis‐ and tris‐pegylating…”
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Synthesis of symmetrically and asymmetrically branched pegylating reagents by Felix, A.M., Bandaranayake, R.M.

“…:  A solution‐phase procedure using an orthogonal protection scheme was developed for the synthesis of a novel family of multi‐pegylating reagents. The…”
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Assessment in humans of a synthetic peptide-based vaccine against the sporozoite stage of the human malaria parasite, Plasmodium falciparum by Etlinger, HM, Felix, AM, Gillessen, D, Heimer, EP, Just, M, Pink, JR, Sinigaglia, F, Sturchler, D, Takacs, B, Trzeciak, A

“…Eleven volunteers were injected with an anti-malaria (Plasmodium falciparum) sporozoite vaccine candidate consisting of a synthetic peptide, Ac-Cys-(NANP)3,…”
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Rapid removal of protecting groups from peptides by catalytic transfer hydrogenation with 1,4-cyclohexadiene by Felix, Arthur M, Heimer, Edgar P, Lambros, Theodore J, Tzougraki, Chryssa, Meienhofer, Johannes

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GRF analogs and fragments: correlation between receptor binding, activity and structure by Campbell, R M, Lee, Y, Rivier, J, Heimer, E P, Felix, A M, Mowles, T F

“…GH-releasing activity in vitro was directly correlated with GRF receptor binding affinity for all hGRF analogs examined. hGRF(1-29)-NH2 analogs with…”
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Localization and growth hormone (GH)-releasing activity of rat testicular GH-releasing hormone-like peptide by Pescovitz, O H, Berry, S A, Laudon, M, Ben-Jonathan, N, Martin-Myers, A, Hsu, S M, Lambros, T J, Felix, A M

“…The testis contains many peptides originally described as originating in the central nervous system. The physiological function of these factors in the testis…”
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Cleavage of protecting groups with boron tribromide by Felix, Arthur M

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Enzymatic semisynthesis of a superpotent analog of human growth hormone-releasing factor by BONGERS, J, LAMBROS, T, LIU, W, AHMAD, M, CAMPBELL, R. M, FELIX, A. M, HEIMER, E. P

“…A superpotent analog of human growth hormone-releasing factor, [desNH2Tyr1,D-Ala2,Ala15]-GRF(1-29)-NH2 (4), was prepared from the precursor,…”
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