Search Results - "Felipe Simon"

Endothelial-to-mesenchymal transition: Cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions by Pérez, Lorena, Muñoz-Durango, Natalia, Riedel, Claudia A, Echeverría, Cesar, Kalergis, Alexis M, Cabello-Verrugio, Claudio, Simon, Felipe, PhD

“…Graphical abstract…”
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Mitochondrial Dysfunction in Skeletal Muscle Pathologies by Abrigo, Johanna, Simon, Felipe, Cabrera, Daniel, Vilos, Cristian, Cabello-Verrugio, Claudio

“…Several molecular mechanisms are involved in the regulation of skeletal muscle function. Among them, mitochondrial activity can be identified. The mitochondria…”
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Early lipopolysaccharide-induced reactive oxygen species production evokes necrotic cell death in human umbilical vein endothelial cells by Simon, Felipe, Fernández, Ricardo

“…BACKGROUNDEndothelial dysfunction is a crucial step in the pathogenesis of cardiovascular diseases. Reactive oxygen species (ROS) generated in response to…”
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Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans by Simon, Felipe, Varela, Diego, Cabello-Verrugio, Claudio

“…The transient receptor potential melastatin (TRPM) protein family is an extensive group of ion channels expressed in several types of mammalian cells. Many…”
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Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia by Cabello-Verrugio, Claudio, Cabrera, Daniel, Simon, F., Vilos, Cristian, Riedel, C. A., Elorza, Alvaro A., Abrigo, Johanna, Estrada, Lisbell

“…Skeletal muscle atrophy is a pathological condition mainly characterized by a loss of muscular mass and the contractile capacity of the skeletal muscle as a…”
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SARS-CoV-2/Renin-Angiotensin System: Deciphering the Clues for a Couple with Potentially Harmful Effects on Skeletal Muscle by Gonzalez, Andrea, Orozco-Aguilar, Josué, Achiardi, Oscar, Simon, Felipe, Cabello-Verrugio, Claudio

“…Severe acute respiratory syndrome coronavirus (SARS-CoV-2) has produced significant health emergencies worldwide, resulting in the declaration by the World…”
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Oxidative Stress in Disease and Aging: Mechanisms and Therapies 2016 by Cabello-Verrugio, Claudio, Simon, Felipe, Trollet, Capucine, Santibañez, Juan F.

“…Oxidative stress (OS) is an imbalance between the formation of reactive oxygen species (ROS) and antioxidant defense mechanisms. This phenomenon increases with…”
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Protective Effect of Angiotensin 1-7 on Sarcopenia Induced by Chronic Liver Disease in Mice by Aguirre, Francisco, Abrigo, Johanna, Gonzalez, Francisco, Gonzalez, Andrea, Simon, Felipe, Cabello-Verrugio, Claudio

“…Sarcopenia associated with chronic liver disease (CLD) is one of the more common extrahepatic features in patients with these pathologies. Among the cellular…”
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Role of the CaV1.2 distal carboxy terminus in the regulation of L-type current by Arancibia, Felipe, De Giorgis, Daniela, Medina, Franco, Hermosilla, Tamara, Simon, Felipe, Varela, Diego

“…L-type calcium channels are essential for the excitation-contraction coupling in cardiac muscle. The CaV1.2 channel is the most predominant isoform in the…”
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Angiotensin (1-7) Decreases Myostatin-Induced NF-κB Signaling and Skeletal Muscle Atrophy by Aravena, Javier, Abrigo, Johanna, Gonzalez, Francisco, Aguirre, Francisco, Gonzalez, Andrea, Simon, Felipe, Cabello-Verrugio, Claudio

“…Myostatin is a myokine that regulates muscle function and mass, producing muscle atrophy. Myostatin induces the degradation of myofibrillar proteins, such as…”
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Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1-7) through a p38 MAPK-dependent mechanism by Morales, María Gabriela, Olguín, Hugo, Di Capua, Gabriella, Brandan, Enrique, Simon, Felipe, Cabello-Verrugio, Claudio

“…Skeletal muscle atrophy induced during sepsis syndrome produced by endotoxin in the form of LPS (lipopolysaccharide), is a pathological condition characterized…”
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Transforming Growth Factor-Beta Family: Advances in Vascular Function and Signaling by Gatica, Sebastian, Cabello-Verrugio, Claudio, Simon, Felipe

“…This review includes a comprehensive, but succinct, summary on the essentials of TGF- β structure, family members, receptors, and intracellular mediators. Also…”
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The angiotensin-(1–7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice by Meneses, Carla, Morales, María Gabriela, Abrigo, Johanna, Simon, Felipe, Brandan, Enrique, Cabello-Verrugio, Claudio

“…Angiotensin-(1–7) [Ang (1–7)] is a peptide belonging to the non-classical renin-angiotensin system (RAS). Ang (1–7), through its receptor Mas, has an opposite…”
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Ursodeoxycholic acid induces sarcopenia associated with decreased protein synthesis and autophagic flux by Orozco-Aguilar, Josué, Tacchi, Franco, Aguirre, Francisco, Valero-Breton, Mayalen, Castro-Sepulveda, Mauricio, Simon, Felipe, Cabello-Verrugio, Claudio

“…Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer an imbalance in protein…”
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Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism by Cisternas, Franco, Morales, María Gabriela, Meneses, Carla, Simon, Felipe, Brandan, Enrique, Abrigo, Johanna, Vazquez, Yaneisi, Cabello-Verrugio, Claudio

“…Skeletal muscle atrophy is a pathological condition characterized by the loss of strength and muscle mass, an increase in myosin heavy chain (MHC) degradation…”
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Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β) via Mas Receptor Activation by Ábrigo, Johanna, Simon, Felipe, Cabrera, Daniel, Cabello-Verrugio, Claudio

“…Background: Transforming growth factor type beta 1 (TGF-β1) produces skeletal muscle atrophy. Angiotensin-(1-7) (Ang-(1-7)), through the Mas receptor, prevents…”
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TRPM Channels in Human Diseases by Jimenez, Ivanka, Prado, Yolanda, Marchant, Felipe, Otero, Carolina, Eltit, Felipe, Cabello-Verrugio, Claudio, Cerda, Oscar, Simon, Felipe

“…The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation channels family. Since the first cloning of TRPM1 in 1989, tremendous…”
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Oxidative Stress in Disease and Aging: Mechanisms and Therapies by Cabello-Verrugio, Claudio, Ruiz-Ortega, Marta, Mosqueira, Matias, Simon, Felipe

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TRPM4 regulates Akt/GSK3‐β activity and enhances β‐catenin signaling and cell proliferation in prostate cancer cells by Sagredo, Alfredo I., Sagredo, Eduardo A., Cappelli, Claudio, Báez, Pablo, Andaur, Rodrigo E., Blanco, Constanza, Tapia, Julio C., Echeverría, César, Cerda, Oscar, Stutzin, Andrés, Simon, Felipe, Marcelain, Katherine, Armisén, Ricardo

“…Increased expression of the TRPM4 channel has been reported to be associated with the progression of prostate cancer. However, the molecular mechanism…”
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Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells by Abrigo, Johanna, Olguín, Hugo, Tacchi, Franco, Orozco-Aguilar, Josué, Valero-Breton, Mayalen, Soto, Jorge, Castro-Sepúlveda, Mauricio, Elorza, Alvaro A, Simon, Felipe, Cabello-Verrugio, Claudio

“…Skeletal muscle is sensitive to bile acids (BA) because it expresses the TGR5 receptor for BA. Cholic (CA) and deoxycholic (DCA) acids induce a sarcopenia-like…”
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