Search Results - "Felder, Thomas"

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain by Marschallinger, Julia, Iram, Tal, Zardeneta, Macy, Lee, Song E., Lehallier, Benoit, Haney, Michael S., Pluvinage, John V., Mathur, Vidhu, Hahn, Oliver, Morgens, David W., Kim, Justin, Tevini, Julia, Felder, Thomas K., Wolinski, Heimo, Bertozzi, Carolyn R., Bassik, Michael C., Aigner, Ludwig, Wyss-Coray, Tony

“…Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing…”
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Friend or Foe: Lipid Droplets as Organelles for Protein and Lipid Storage in Cellular Stress Response, Aging and Disease by Geltinger, Florian, Schartel, Lukas, Wiederstein, Markus, Tevini, Julia, Aigner, Elmar, Felder, Thomas K, Rinnerthaler, Mark

“…Lipid droplets (LDs) were considered as a mere lipid storage organelle for a long time. Recent evidence suggests that LDs are in fact distinct and dynamic…”
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Iron homeostasis in the Metabolic Syndrome by Datz, Christian, Felder, Thomas K., Niederseer, David, Aigner, Elmar

“…The metabolic syndrome (MetS) affects iron homeostasis in a many‐faceted fashion. On the one side, hyperferritinaemia with normal or mildly elevated…”
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Clinical and Metabolic Characterization of Lean Caucasian Subjects With Non-alcoholic Fatty Liver by Feldman, Alexandra, Eder, Sebastian K, Felder, Thomas K, Kedenko, Lyudmyla, Paulweber, Bernhard, Stadlmayr, Andreas, Huber-Schönauer, Ursula, Niederseer, David, Stickel, Felix, Auer, Simon, Haschke-Becher, Elisabeth, Patsch, Wolfgang, Datz, Christian, Aigner, Elmar

“…Non-alcoholic fatty liver disease (NAFLD) is closely linked to obesity; however, 5-8% of lean subjects also have evidence of NAFLD. We aimed to investigate…”
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Dexmedetomidine Added to Ropivacaine Extends the Duration of Interscalene Brachial Plexus Blocks for Elective Shoulder Surgery When Compared with Ropivacaine Alone: A Single-Center, Prospective, Triple-Blind, Randomized Controlled Trial by Fritsch, Gerhard, Danninger, Thomas, Allerberger, Karl, Tsodikov, Alexander, Felder, Thomas K, Kapeller, Monika, Gerner, Peter, Brummett, Chad M

“…BACKGROUND AND OBJECTIVESResearch suggests that the addition of dexmedetomidine to local anesthetics can prolong peripheral nerve blocks; however, clinical…”
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Immunometabolism as predictor of frailty by Gostner, Johanna M, Laffon, Blanca, Felder, Thomas K

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Are laboratory tests always needed? Frequency and causes of laboratory overuse in a hospital setting by Cadamuro, Janne, Gaksch, Martin, Wiedemann, Helmut, Lippi, Giuseppe, von Meyer, Alexander, Pertersmann, Astrid, Auer, Simon, Mrazek, Cornelia, Kipman, Ulrike, Felder, Thomas K., Oberkofler, Hannes, Haschke-Becher, Elisabeth

“…Inappropriate utilization of laboratory resources is an increasing concern especially in high-throughput facilities. Until now, no reliable information has…”
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Diacerein orphan drug development for epidermolysis bullosa simplex: A phase 2/3 randomized, placebo-controlled, double-blind clinical trial by Wally, Verena, Hovnanian, Alain, Ly, Juliette, Buckova, Hana, Brunner, Victoria, Lettner, Thomas, Ablinger, Michael, Felder, Thomas K., Hofbauer, Peter, Wolkersdorfer, Martin, Lagler, Florian B., Hitzl, Wolfgang, Laimer, Martin, Kitzmüller, Sophie, Diem, Anja, Bauer, Johann W.

“…Epidermolysis bullosa simplex (EBS) is a rare genetic, blistering skin disease for which there is no cure. Treatments that address the pathophysiology of EBS…”
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The PPARGC1A locus and CNS-specific PGC-1α isoforms are associated with Parkinson's Disease by Soyal, Selma M., Zara, Greta, Ferger, Boris, Felder, Thomas K., Kwik, Markus, Nofziger, Charity, Dossena, Silvia, Schwienbacher, Christine, Hicks, Andrew A., Pramstaller, Peter P., Paulmichl, Markus, Weis, Serge, Patsch, Wolfgang

“…Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. PGC-1α, encoded by PPARGC1A, is a transcriptional co-activator that has…”
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Diagnostic Workup of Microcytic Anemia: An Evaluation of Underuse or Misuse of Laboratory Testing in a Hospital Setting Using the AlinIQ System by Cadamuro, Janne, Simundic, Ana-Maria, von Meyer, Alexander, Haschke-Becher, Elisabeth, Keppel, Martin H, Oberkofler, Hannes, Felder, Thomas K, Mrazek, Cornelia

“…Underuse of laboratory testing has been previously investigated in preselected populations, such as documented malpractice claims. However, these numbers might…”
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Melatonin in Human Breast Milk and Its Potential Role in Circadian Entrainment: A Nod towards Chrononutrition? by Häusler, Silke, Lanzinger, Emma, Sams, Elke, Fazelnia, Claudius, Allmer, Kevin, Binder, Christoph, Reiter, Russel J, Felder, Thomas K

“…Breastfeeding is the most appropriate source of a newborn's nutrition; among the plethora of its benefits, its modulation of circadian rhythmicity with…”
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Heart-Type Fatty Acid-Binding Protein (H-FABP) and its Role as a Biomarker in Heart Failure: What Do We Know So Far? by Rezar, Richard, Jirak, Peter, Gschwandtner, Martha, Derler, Rupert, Felder, Thomas K, Haslinger, Michael, Kopp, Kristen, Seelmaier, Clemens, Granitz, Christina, Hoppe, Uta C, Lichtenauer, Michael

“…Heart failure (HF) remains one of the leading causes of death to date despite extensive research funding. Various studies are conducted every year in an…”
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Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast by Rinnerthaler, Mark, Büttner, Sabrina, Laun, Peter, Heeren, Gino, Felder, Thomas K, Klinger, Harald, Weinberger, Martin, Stolze, Klaus, Grousl, Tomas, Hasek, Jiri, Benada, Oldrich, Frydlova, Ivana, Klocker, Andrea, Simon-Nobbe, Birgit, Jansko, Bettina, Breitenbach-Koller, Hannelore, Eisenberg, Tobias, Gourlay, Campbell W, Madeo, Frank, Burhans, William C, Breitenbach, Michael

“…The large protein superfamily of NADPH oxidases (NOX enzymes) is found in members of all eukaryotic kingdoms: animals, plants, fungi, and protists. The…”
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Errors within the total laboratory testing process, from test selection to medical decision-making - A review of causes, consequences, surveillance and solutions by Mrazek, Cornelia, Lippi, Giuseppe, Keppel, Martin H, Felder, Thomas K, Oberkofler, Hannes, Haschke-Becher, Elisabeth, Cadamuro, Janne

“…Laboratory analyses are crucial for diagnosis, follow-up and treatment decisions. Since mistakes in every step of the total testing process may potentially…”
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Topical Diacerein Decreases Skin and Splenic CD11c + Dendritic Cells in Psoriasis by Brunner, Susanne M, Ramspacher, Andrea, Rieser, Caroline, Leitner, Julia, Heil, Hannah, Ablinger, Michael, Tevini, Julia, Wimmer, Monika, Koller, Andreas, Piñón Hofbauer, Josefina, Felder, Thomas K, Bauer, Johann W, Kofler, Barbara, Lang, Roland, Wally, Verena

“…Psoriasis is an inflammatory skin disease characterized by increased neo-vascularization, keratinocyte hyperproliferation, a pro-inflammatory cytokine milieu…”
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Development and Characterization of the Neuroregenerative Xanthohumol C/Hydroxypropyl-β-cyclodextrin Complex Suitable for Parenteral Administration by Kirchinger, Michael, Bieler, Lara, Tevini, Julia, Vogl, Michael, Haschke-Becher, Elisabeth, Felder, Thomas K, Couillard-Després, Sebastien, Riepl, Herbert, Urmann, Corinna

“…The chroman-like chalcone Xanthohumol C, originally found in hops, was demonstrated to be a potent neuroregenerative and neuroprotective natural product and…”
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Inappropriate use of laboratory tests: How availability triggers demand – Examples across Europe by Mrazek, Cornelia, Simundic, Ana-Maria, Salinas, Maria, von Meyer, Alexander, Cornes, Michael, Bauçà, Josep Miquel, Nybo, Mads, Lippi, Giuseppe, Haschke-Becher, Elisabeth, Keppel, Martin H., Oberkofler, Hannes, Felder, Thomas K., Cadamuro, Janne

“…•Increased availability of laboratory tests increases the number of orders.•Ease of use is contributing to overutilization of laboratory tests.•Simple…”
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A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset by SOYAL, Selma M, FELDER, Thomas K, AUER, Simon, HAHNE, Penelope, OBERKOFLER, Hannes, WITTING, Anke, PAULMICHL, Markus, BERNHARD LANDWEHRMEYER, G, WEYDT, Patrick, PATSCH, Wolfgang

“…PGC-1α has been implicated in the pathogenesis of neurodegenerative disorders. Several single-nucleotide polymorphisms (SNPs) located in two separate haplotype…”
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Soluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study by Rezar, Richard, Paar, Vera, Seelmaier, Clemens, Pretsch, Ingrid, Schwaiger, Philipp, Kopp, Kristen, Kaufmann, Reinhard, Felder, Thomas K., Prinz, Erika, Gemes, Geza, Pistulli, Rudin, Hoppe, Uta C., Wernly, Bernhard, Lichtenauer, Michael

“…Prognostication after cardiopulmonary resuscitation (CPR) is complex. Novel biomarkers like soluble suppression of tumorigenicity 2 (sST2) may provide an…”
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Changing the tide in vitamin D testing: An 8-year review of a demand management approach by Cadamuro, Janne, Huber-Schönauer, Ursula, Mrazek, Cornelia, Hehenwarter, Lukas, Kipman, Ulrike, Felder, Thomas K, Pirich, Christian

“…• Adding a mandatory accompanying information in the Vitamin D ordering process led to a significant reduction overall orders • Given that about one third of…”
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