Biopharmaceuticals from microorganisms: from production to purification

Biopharmaceuticals from microorganisms: from production to purification

The use of biopharmaceuticals dates from the 19th century and within 5–10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons...

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Bibliographic Details
Published in:Brazilian journal of microbiology Vol. 47; no. S1; pp. 51 - 63
Main Authors: Jozala, Angela Faustino, Geraldes, Danilo Costa, Tundisi, Louise Lacalendola, Feitosa, Valker de Araújo, Breyer, Carlos Alexandre, Cardoso, Samuel Leite, Mazzola, Priscila Gava, Oliveira-Nascimento, Laura de, Rangel-Yagui, Carlota de Oliveira, Magalhães, Pérola de Oliveira, Oliveira, Marcos Antonio de, Pessoa, Adalberto
Format: Journal Article
Language:English
Published: Brazil Elsevier Editora Ltda 01-12-2016
Springer Nature B.V
Elsevier
Sociedade Brasileira de Microbiologia
Subjects:
Biological Products
Biopharmaceuticals
Biosimilar Pharmaceuticals
Biotechnology
Downstream process
Drug Industry
Fermentation
Fermentation process
Humans
Microbiological Techniques
MICROBIOLOGY
Pharmaceutical Preparations
Pharmaceutical sciences
Recombinant Proteins
Review
Upstream process
Fermentation process
Biotechnology
Biopharmaceuticals
Downstream process
Upstream process
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Summary:The use of biopharmaceuticals dates from the 19th century and within 5–10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1517-8382
1678-4405
1678-4405
DOI:10.1016/j.bjm.2016.10.007