Search Results - "Feit, Peter W."

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy by Töllner, Kathrin, Brandt, Claudia, Töpfer, Manuel, Brunhofer, Gerda, Erker, Thomas, Gabriel, Mario, Feit, Peter W., Lindfors, Jenna, Kaila, Kai, Löscher, Wolfgang

“…Objective There is considerable interest in using bumetanide, a chloride importer Na‐K‐Cl cotransporter antagonist, for treatment of neurological diseases,…”
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Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy by Brandt, Claudia, Seja, Patricia, Töllner, Kathrin, Römermann, Kerstin, Hampel, Philip, Kalesse, Markus, Kipper, Andi, Feit, Peter W., Lykke, Kasper, Toft-Bertelsen, Trine Lisberg, Paavilainen, Pauliina, Spoljaric, Inkeri, Puskarjov, Martin, MacAulay, Nanna, Kaila, Kai, Löscher, Wolfgang

“…Based on the potential role of Na-K-Cl cotransporters (NKCCs) in epileptic seizures, the loop diuretic bumetanide, which blocks the NKCC1 isoforms NKCC1 and…”
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The search for NKCC1-selective drugs for the treatment of epilepsy: Structure–function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A by Lykke, Kasper, Töllner, Kathrin, Feit, Peter W, Erker, Thomas, MacAulay, Nanna, Löscher, Wolfgang

“…Abstract The Na+ –K+ –Cl− cotransporter NKCC1 plays a major role in the regulation of intraneuronal Cl− concentration. Abnormal functionality of NKCC1 has been…”
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Structure–activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC2A transporter by Lykke, Kasper, Töllner, Kathrin, Römermann, Kerstin, Feit, Peter W, Erker, Thomas, MacAulay, Nanna, Löscher, Wolfgang

“…Background and Purpose The N‐K‐Cl cotransporters (NKCCs) mediate the coupled, electroneutral movement of Na+, K+ and Cl− ions across cell membranes. There are…”
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Corrigendum to “Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's antiseizure efficacy” [Neuropharmacology 143 (2018) 186–204] by Brandt, Claudia, Seja, Patricia, Töllner, Kathrin, Römermann, Kerstin, Hampel, Philip, Kalesse, Markus, Kipper, Andi, Feit, Peter W., Lykke, Kasper, Toft-Bertelsen, Trine Lisberg, Paavilainen, Pauliina, Spoljaric, Inkeri, Puskarjov, Martin, MacAulay, Nanna, Kaila, Kai, Löscher, Wolfgang

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1,4-Bismethanesulfonates of the Stereoisomeric Butanetetraols and Related Compounds by Feit, Peter W

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Structure–activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC 2 A transporter by Lykke, Kasper, Töllner, Kathrin, Römermann, Kerstin, Feit, Peter W, Erker, Thomas, MacAulay, Nanna, Löscher, Wolfgang

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Epoxide formation from (2S,3S)-threitol 1,4-bismethanesulfonate. Preparation and biological activity of (2S,3S)-1,2-epoxy-3,4-butanediol 4-methanesulfonate by Feit, Peter W, Rastrup-Andersen, Niels, Matagne, Rene

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Aminobenzoic acid diuretics. 2. 4-Substituted-3-amino-5-sulfamoylbenzoic acid derivatives by Feit, Peter W

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Alkylating Agents Related to 2,2′-Biaziridine. II.1 N,N′-Dicarbethoxy-2,2′-biaziridine by Feit, Peter W, Nielsen, Ole Tvaermose

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Aminobenzoic acid diuretics. 7. 3-Substituted 4-phenyl-, 4-arylcarbonyl-, and 4-arylmethyl-5-sulfamoylbenzoic acids and related compounds by Nielsen, Ole B. Tvaermose, Bruun, Herta, Bretting, Claus, Feit, Peter W

“…Various 4-substituted 3-alkylamino-, 3-alkoxy-, 3-alkylthio-, and 3-alkyl-5-sulfamoylbenzoic acids related to known aminobenzoic acid diuretics were…”
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Alkylating agents related to 2,2'-biaziridine. III. Stereoisomeric N,N'-dimethylsulfonyl-2,2'-biaziridines by Feit, Peter W, Nielsen, Ole T

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Aminobenzoic acid diuretics. 9. 3,4-Disubstituted 5-acylaminobenzoic acids and related compounds by Feit, Peter W, Nielsen, Ole B. Tvaermose

“…A number of 3,4-disubstituted 5-acylamino-, 5-alkylamino-, and 5-ureidobenzoic acids corresponding to previously described 3,4-disubstituted 5-sulfamoylbenzoic…”
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Aminobenzoic acid diuretics. 3. 4-Substituted 5-sulfamylanthranilic acid derivatives by Feit, Peter W, Tvaermose Nielsen, Ole B

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Compounds Derived from L-Threitol 1,4-Bismethanesulfonate by Feit, Peter W

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Aminobenzoic acid diuretics. 5. 3-Amino-4-arylmethyl-5-sulfamylbenzoic acid derivatives and related compounds by Nielsen, Ole B. Tvaermose, Nielsen, Christian Kaergaard, Feit, Peter W

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Aminobenzoic acid diuretics. 4. 4-Benzyl-5-sulfamylanthranilic acid derivatives and related 1,2-benzisothiazole 1,1-dioxides by Feit, Peter W, Nielsen, Ole B. Tvaermose, Rastrup-Andersen, Niels

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Aminobenzoic acid diuretics. 6. 4-Substituted 3-alkylthio-5-sulfamoylbenzoic and 5-sulfamoylthiosalicylic acids by Feit, Peter W, Nielsen, Ole B. Tvaermose, Bruun, Herta

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Aminobenzoic acid diuretics. 1. 4-Halogeno-5-sulfamylmetanilic acid derivatives by Feit, Peter W, Bruun, Herta, Nielsen, Christian K

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Alkylating Agents Related to 2,2′-Biaziridine. I. Compounds Derived from 1,4-Diamino-2,3-butanediol by Feit, Peter W, Nielsen, Ole Tvaermose

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