Search Results - "Feinstein, Douglas L."

Causes, consequences, and cures for neuroinflammation mediated via the locus coeruleus: noradrenergic signaling system by Feinstein, Douglas L., Kalinin, Sergey, Braun, David

“…Aside from its roles in as a classical neurotransmitter involved in regulation of behavior, noradrenaline (NA) has other functions in the CNS. This includes…”
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Neuroinflammation in Alzheimer's disease by Heneka, Michael T, Prof, Carson, Monica J, Prof, Khoury, Joseph El, Prof, Landreth, Gary E, Prof, Brosseron, Frederic, PhD, Feinstein, Douglas L, Prof, Jacobs, Andreas H, Prof, Wyss-Coray, Tony, Prof, Vitorica, Javier, Prof, Ransohoff, Richard M, Prof, Herrup, Karl, Prof, Frautschy, Sally A, Prof, Finsen, Bente, Prof, Brown, Guy C, Prof, Verkhratsky, Alexei, Prof, Yamanaka, Koji, Prof, Koistinaho, Jari, Prof, Latz, Eicke, Prof, Halle, Annett, MD, Petzold, Gabor C, Prof, Town, Terrence, Prof, Morgan, Dave, Prof, Shinohara, Mari L, Prof, Perry, V Hugh, Prof, Holmes, Clive, Prof, Bazan, Nicolas G, Prof, Brooks, David J, Prof, Hunot, Stéphane, PhD, Joseph, Bertrand, Prof, Deigendesch, Nikolaus, MD, Garaschuk, Olga, Prof, Boddeke, Erik, Prof, Dinarello, Charles A, Prof, Breitner, John C, Prof, Cole, Greg M, Prof, Golenbock, Douglas T, Prof, Kummer, Markus P, PhD

“…Summary Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with…”
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mTOR kinase, a key player in the regulation of glial functions: Relevance for the therapy of multiple sclerosis by Dello Russo, Cinzia, Lisi, Lucia, Feinstein, Douglas L., Navarra, Pierluigi

“…The mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase with a central role in the regulation of cell growth and proliferation, and…”
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Non-adherence with long-term oral vitamin K1 therapy in acute long-acting anticoagulant rodenticides poisoning: A call for action by Rubinstein, Israel, Kaul, Malvika, Feinstein, Douglas L

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Investigating the metabolite signature of an altered oral microbiota as a discriminant factor for multiple sclerosis: a pilot study by Boussamet, Léo, Montassier, Emmanuel, Mathé, Camille, Garcia, Alexandra, Morille, Jérémy, Shah, Sita, Dugast, Emilie, Wiertlewski, Sandrine, Gourdel, Mathilde, Bang, Corinna, Stürner, Klarissa H., Masson, Damien, Nicot, Arnaud B., Vince, Nicolas, Laplaud, David-Axel, Feinstein, Douglas L., Berthelot, Laureline

“…In multiple sclerosis (MS), alterations of the gut microbiota lead to inflammation. However, the role of other microbiomes in the body in MS has not been fully…”
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Lanthionine ketimine ester provides benefit in a mouse model of multiple sclerosis by Dupree, Jeffrey L., Polak, Paul E., Hensley, Kenneth, Pelligrino, Dale, Feinstein, Douglas L.

“…Lanthionine ketimine (LK) is a natural sulfur amino acid metabolite which binds to collapsin response mediator protein‐2 (CRMP2), an abundant brain protein…”
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Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis by Kalinin, Sergey, González-Prieto, Marta, Scheiblich, Hannah, Lisi, Lucia, Kusumo, Handojo, Heneka, Michael T, Madrigal, Jose L M, Pandey, Subhash C, Feinstein, Douglas L

“…Microglial activation contributes to the neuropathology associated with chronic alcohol exposure and withdrawal, including the expression of inflammatory and…”
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Resuscitation with Lipid versus Epinephrine in a Rat Model of Bupivacaine Overdose by WEINBERG, Guy L, DI GREGORIO, Guido, RIPPER, Richard, KELLY, Kemba, MASSAD, Malek, EDELMAN, Lucas, SCHWARTZ, David, SHAH, Nirali, ZHENG, Sophie, FEINSTEIN, Douglas L

“…Lipid emulsion infusion reverses cardiovascular compromise due to local anesthetic overdose in laboratory and clinical settings. The authors compared…”
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The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes by Lisi, Lucia, Navarra, Pierluigi, Feinstein, Douglas L, Dello Russo, Cinzia

“…Reactive astrocytes are capable of producing a variety of pro-inflammatory mediators and potentially neurotoxic compounds, including nitric oxide (NO). High…”
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History of Neuroscience I. Pío del Río-Hortega (1882–1945): The Discoverer of Microglia and Oligodendroglia by Boullerne, Anne I., Feinstein, Douglas L.

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Uptake and Distribution of Administered Bone Marrow Mesenchymal Stem Cell Extracellular Vesicles in Retina by Mathew, Biji, Torres, Leianne A, Gamboa Acha, Lorea, Tran, Sophie, Liu, Alice, Patel, Raj, Chennakesavalu, Mohansrinivas, Aneesh, Anagha, Huang, Chun-Chieh, Feinstein, Douglas L, Mehraeen, Shafigh, Ravindran, Sriram, Roth, Steven

“…Cell replacement therapy using mesenchymal (MSC) and other stem cells has been evaluated for diabetic retinopathy and glaucoma. This approach has significant…”
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Inhaled synthetic cannabinoids laced with long-acting anticoagulant rodenticides: a clear and present worldwide danger by Feinstein, Douglas L., Hafner, John, van Breemen, Richard, Rubinstein, Israel

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Astrocyte-Derived MCP-1 Mediates Neuroprotective Effects of Noradrenaline by Madrigal, Jose L. M, Leza, Juan C, Polak, Paul, Kalinin, Sergey, Feinstein, Douglas L

“…The neurotransmitter noradrenaline (NA) can provide neuroprotection against insults including inflammatory stimuli and excitotoxicity, which may involve…”
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Conditional Depletion of Hippocampal Brain-Derived Neurotrophic Factor Exacerbates Neuropathology in a Mouse Model of Alzheimer’s Disease by Braun, David J., Kalinin, Sergey, Feinstein, Douglas L.

“…Damage occurring to noradrenergic neurons in the locus coeruleus (LC) contributes to the evolution of neuroinflammation and neurodegeneration in a variety of…”
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Lipid emulsion is superior to vasopressin in a rodent model of resuscitation from toxin-induced cardiac arrest by Di Gregorio, Guido, Schwartz, David, Ripper, Richard, Kelly, Kemba, Feinstein, Douglas L, Minshall, Richard D, Massad, Malek, Ori, Carlo, Weinberg, Guy L

“…OBJECTIVES:Lipid emulsion infusion is an emerging antidotal therapy for toxin-induced cardiac arrest. To compare the efficacy of resuscitation from…”
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P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis by Sharp, Anthony J, Polak, Paul E, Simonini, Vittoria, Lin, Shao X, Richardson, Jill C, Bongarzone, Ernesto R, Feinstein, Douglas L

“…The purinergic receptor P2x7 is expressed on myeloid cells as well as on CNS glial cells, and P2x7 activation has been shown to increase both glial and T-cell…”
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Elena Galea (1962–2023) by Feinstein, Douglas L.

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The anti-inflammatory effects of dimethyl fumarate in astrocytes involve glutathione and haem oxygenase-1 by Lin, Shao Xia, Lisi, Lucia, Dello Russo, Cinzia, Polak, Paul E, Sharp, Anthony, Weinberg, Guy, Kalinin, Sergey, Feinstein, Douglas L

“…DMF (dimethyl fumarate) exerts anti-inflammatory and pro-metabolic effects in a variety of cell types, and a formulation (BG-12) is being evaluated for…”
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Membrane Cholesterol Modulates Superwarfarin Toxicity by Marangoni, M. Natalia, Martynowycz, Michael W., Kuzmenko, Ivan, Braun, David, Polak, Paul E., Weinberg, Guy, Rubinstein, Israel, Gidalevitz, David, Feinstein, Douglas L.

“…Superwarfarins are modified analogs of warfarin with additional lipophilic aromatic rings, up to 100-fold greater potency, and longer biological half-lives. We…”
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Severe Vitamin K-dependent Coagulopathy from Rodenticide-contaminated Synthetic Cannabinoids: Emergency Department Presentations by Wright, Erik, Hafner, John W, Podolej, Gregory, Feinstein, Douglas L, van Breemen, Richard, Rubinstein, Israel, Aks, Steven, Wahl, Michael

“…Synthetic cannabinoids are a rapidly expanding subset of designer drugs widely available in the United States since 2008. In Illinois during the spring of…”
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