Search Results - "Feinstein, D L"

Receptor-independent actions of PPAR thiazolidinedione agonists: Is mitochondrial function the key? by Feinstein, D.L., Spagnolo, A., Akar, C., Weinberg, G., Murphy, P., Gavrilyuk, V., Russo, C. Dello

“…Agonists of the peroxisome proliferator activated receptor gamma (PPARγ) are currently used for treatment of type 2 diabetes due to their insulin sensitizing…”
Get full text

Pioglitazone does not increase cerebral glucose utilisation in a murine model of Alzheimer's disease and decreases it in wild-type mice by GALEA, E, FEINSTEIN, D. L, LACOMBE, P

“…Clinical trials are in progress to test thiazolidinediones in neurodegenerative diseases such as Alzheimer's disease that involve deficiencies in brain glucose…”
Get full text

Expression of iNOS, CD163 and ARG-1 taken as M1 and M2 markers of microglial polarization in human glioblastoma and the surrounding normal parenchyma by Lisi, L., Ciotti, G.M.P., Braun, D., Kalinin, S., Currò, D., Dello Russo, C., Coli, A., Mangiola, A., Anile, C., Feinstein, D.L., Navarra, P.

“…•iNOS, CD163 and ARG-I were investigated in GBM tumors and in the surrounding parenchyma from the same patients.•CD163 expression was higher within GBM…”
Get full text

Induction of Calcium-Independent Nitric Oxide Synthase Activity in Primary Rat Glial Cultures by Galea, Elena, Feinstein, Douglas L., Reis, Donald J.

“…Exposure of primary cultures of neonatal rat cortical astrocytes to bacterial lipopolysaccharide (LPS) results in the appearance of nitric oxide synthase (NOS)…”
Get full text

Influence of the glia limitans on pial arteriolar relaxation in the rat by Xu, H L, Koenig, H M, Ye, S, Feinstein, D L, Pelligrino, D A

“…We examined whether damage to the glia limitans (GL), via exposure to the gliotoxin l-alpha-aminoadipic acid (l-alphaAAA), alters hypercapnia-induced pial…”
Get more information

Cloning and expression of inducible nitric oxide synthase from rat astrocytes by Galea, E, Reis, D J, Feinstein, D L

“…In primary cultures of rat astroglial cells exposure to bacterial endotoxin lipopolysaccharide (LPS) causes induction of a Ca(2+)-independent form of the…”
Get more information

Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase by Heneka, Michael T, L. Feinstein, Douglas, Galea, Elena, Gleichmann, Marc, Wüllner, Ullrich, Klockgether, Thomas

“…Cerebellar granule cells (CGCs) can express the inducible isoform of nitric oxide synthase (iNOS) in response to inflammatory stimuli. We demonstrate that…”
Get full text

Synthesis of nitric oxide in CNS glial cells by Murphy, S, Simmons, M L, Agullo, L, Garcia, A, Feinstein, D L, Galea, E, Reis, D J, Minc-Golomb, D, Schwartz, J P

“…Attention has focused on particular neurons as the source of nitric oxide (NO) within the parenchyma of the CNS. In contrast, glial cells have been viewed…”
Get more information

Anti-Proliferative and Anti-Inflammatory Actions of Imidazoline Agents: Are Imidazoline Receptors Involved? by REGUNATHAN, S., FEINSTEIN, D. L., REIS, D. J.

“…We have shown that cultured vascular smooth muscle cells (VSMC) and brain astroglial cells express I‐receptors of the I;i2 subtype. While imidazoline agents…”
Get full text

Rapamycin reduces clinical signs and neuropathic pain in a chronic model of experimental autoimmune encephalomyelitis by Lisi, L, Navarra, P, Cirocchi, R, Sharp, A, Stigliano, E, Feinstein, D.L, Dello Russo, C

“…Abstract Current treatments used in Multiple Sclerosis (MS) are partly effective in the early stages of the disease but display very limited benefits in…”
Get full text

Suppression of Astroglial Nitric Oxide Synthase Expression by Norepinephrine Results from Decreased NOS‐2 Promoter Activity by Feinstein, Douglas L.

“…: We previously demonstrated that norepinephrine (NE) inhibits induction of the calcium‐independent isoform of nitric oxide synthase (NOS‐2) in primary rat…”
Get full text

Potentiation of Astroglial Nitric Oxide Synthase Type‐2 Expression by Lithium Chloride by Feinstein, Douglas L.

“…: The mechanisms underlying the antimanic effects of lithium are largely unknown but may involve long‐term changes in brain gene expression. To determine if…”
Get full text

Agonist-specific differences in mechanisms mediating eNOS-dependent pial arteriolar dilation in rats by Xu, H-L, Feinstein, D L, Santizo, R A, Koenig, H M, Pelligrino, D A

“…Nitric oxide (NO), derived from the endothelial isoform of NO synthase (eNOS), is a vital mediator of cerebral vasodilation. In the present study, we addressed…”
Get more information

Isolation of cDNA clones encoding rat glial fibrillary acidic protein: expression in astrocytes and in Schwann cells by Feinstein, D L, Weinmaster, G A, Milner, R J

“…Glial fibrillary acidic protein (GFAP) expressed by astrocytes in the central nervous system (CNS) has been extensively characterized but the molecular…”
Get more information

Expression of non-adrenergic imidazoline sites in rat cerebral cortical astrocytes by Regunathan, S, Feinstein, D L, Reis, D J

“…Clonidine and related imidazoline agents, beside binding to alpha 2-adrenergic receptors, have been shown to bind to a non-adrenergic site (imidazoline sites)…”
Get more information

Locus coeruleus damage and noradrenaline reductions in multiple sclerosis and experimental autoimmune encephalomyelitis by POLAK, Paul E, KALININ, Sergey, FEINSTEIN, Douglas L

Get full text

Inhibitory and Stimulatory Effects of Lactacystin on Expression of Nitric Oxide Synthase Type 2 in Brain Glial Cells: the role of I Kappa B- beta by Stasiolek, M, Gavrilyuk, V, Sharp, A, Horvath, P, Selmaj, K, Feinstein, D L

“…Expression of inflammatory nitric oxide synthase (NOS2) is mediated by transcription factor NF Kappa B. By using the specific proteasome inhibitor lactacystin…”
Get full text

Induction of nitric oxide synthase in rat C6 glioma cells by Feinstein, D L, Galea, E, Roberts, S, Berquist, H, Wang, H, Reis, D J

“…We have examined the induction of nitric oxide synthase (NOS) activity in the rat astrocyte-derived C6 glioma cell line. In contrast to the previous results…”
Get more information

Inhibition of astroglial nitric oxide synthase type 2 expression by idazoxan by Feinstein, D L, Reis, D J, Regunathan, S

“…Binding of idazoxan (IDA) to imidazoline receptors of the I2 subtype in astrocytes influences astroglial gene expression as evidenced by increased expression…”
Get more information

Norepinephrine suppresses inducible nitric oxide synthase activity in rat astroglial cultures by Feinstein, D L, Galea, E, Reis, D J

“…Exposure of primary rat astrocyte cultures to bacterial endotoxin lipopolysaccharide (LPS) causes expression of a Ca(2+)-independent form of nitric oxide…”
Get more information