Search Results - "Feinberg, A P"

Common DNA methylation alterations in multiple brain regions in autism by Ladd-Acosta, C, Hansen, K D, Briem, E, Fallin, M D, Kaufmann, W E, Feinberg, A P

“…Autism spectrum disorders (ASD) are increasingly common neurodevelopmental disorders defined clinically by a triad of features including impairment in social…”
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Epigenetic stochasticity, nuclear structure and cancer: the implications for medicine by Feinberg, A. P.

“…The aim of this review is to summarize an evolution of thinking about the epigenetic basis of human cancer, from the earliest studies of altered DNA…”
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Epigenetic memory in induced pluripotent stem cells by Feinberg, A. P, Daley, G. Q, Kim, K, Doi, A, Wen, B, Ng, K, Zhao, R, Cahan, P, Kim, J, Aryee, M. J, Ji, H, Ehrlich, L. I. R, Yabuuchi, A, Takeuchi, A, Cunniff, K. C, Hongguang, H, Mckinney-Freeman, S, Naveiras, O, Yoon, T. J, Irizarry, R. A, Jung, N, Seita, J, Hanna, J, Murakami, P, Jaenisch, R, Weissleder, R, Orkin, S. H, Weissman, I. L

“…Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can…”
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Detection of haplotype-dependent allele-specific DNA methylation in WGBS data by Abante, J., Fang, Y., Feinberg, A. P., Goutsias, J.

“…In heterozygous genomes, allele-specific measurements can reveal biologically significant differences in DNA methylation between homologous alleles associated…”
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Imprinting of a genomic domain of 11p15 and loss of imprinting in cancer : An introduction by FEINBERG, A. P

“…Our laboratory has found genomic imprinting of a large genomic domain of human 11p15.5, identifying six imprinted genes within this domain: (a) insulin-like…”
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Loss of Imprinting of Insulin-Like Growth Factor-II (IGF2) Gene in Distinguishing Specific Biologic Subtypes of Wilms Tumor by Ravenel, Jason D., Broman, Karl W., Perlman, Elizabeth J., Niemitz, Emily L., Jayawardena, Tilanthi M., Bell, Daphne W., Haber, Daniel A., Uejima, Hiroshi, Feinberg, Andrew P.

“…Background: Loss of imprinting (LOI) of the insulin-like growth factor-II (IGF2) gene, an epigenetic alteration associated with expression of the normally…”
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Nanoelectromechanics of Methylated DNA in a Synthetic Nanopore by Mirsaidov, U., Timp, W., Zou, X., Dimitrov, V., Schulten, K., Feinberg, A.P., Timp, G.

“…Methylation of cytosine is a covalent modification of DNA that can be used to silence genes, orchestrating a myriad of biological processes including cancer…”
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Cancer Epigenetics Takes Center Stage by Feinberg, Andrew P.

“…Feinberg considers how cancer epigenetics has overcome initial objections, focusing on a new study by Nakagawa et al. The distinction between cancer genetics…”
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Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice by Lee, M P, Ravenel, J D, Hu, R J, Lustig, L R, Tomaselli, G, Berger, R D, Brandenburg, S A, Litzi, T J, Bunton, T E, Limb, C, Francis, H, Gorelikow, M, Gu, H, Washington, K, Argani, P, Goldenring, J R, Coffey, R J, Feinberg, A P

“…The KvLQT1 gene encodes a voltage-gated potassium channel. Mutations in KvLQT1 underlie the dominantly transmitted Ward-Romano long QT syndrome, which causes…”
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Methylation meets genomics by Feinberg, Andrew P

“…The methylome--a neologism that describes the complete set of DNA methylation modifications of a cell--has its own life cycle, and alterations in the methylome…”
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LIT1, an Imprinted Antisense RNA in the Human KvLQT1 Locus Identified by Screening for Differentially Expressed Transcripts Using Monochromosomal Hybrids by Mitsuya, Kohzoh, Meguro, Makiko, Lee, Maxwell P., Katoh, Motonobu, Schulz, Thomas C., Kugoh, Hiroyuki, Yoshida, Mitsuaki A., Niikawa, Norio, Feinberg, Andrew P., Oshimura, Mitsuo

“…Mammalian imprinted genes are frequently arranged in clusters on particular chromosomes. The imprinting cluster on human chromosome 11p15 is associated with…”
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DNA methylation, genomic imprinting and cancer by Feinberg, A P

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Human KVLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangements by Lee, Maxwell P, Hu, Ren-JuHu, Johnson, Laura A, Feinberg, Andrew P

“…Genomic imprinting is an epigenetic chromosomal modification in the gamete or zygote causing preferential expression of a specific parental allele in somatic…”
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Targeted regulation of imprinted genes by synthetic zinc-finger transcription factors by JOUVENOT, Y, GINJALA, V, ZHANG, L, LIU, P-Q, OSHIMURA, M, FEINBERG, A. P, WOLFFE, A. P, OHLSSON, Rolf, GREGORY, P. D

“…Epigenetic control of transcription is essential for mammalian development and its deregulation causes human disease. For example, loss of proper imprinting…”
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Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour by Steenman, Marja J. C, Rainier, Shirley, Dobry, Craig J, Grundy, Paul, Horon, Isabelle L, Feinberg, Andrew P

“…The insulin-like growth factor-II (IGF2) and H19 genes are imprinted in mouse and human, with expression of the paternal IGF2 and maternal H19 alleles. IGF2…”
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Relaxation of imprinted genes in human cancer by Rainier, Shirley, Johnson, Laura A, Dobry, Craig J, Ping, April J, Grundy, Paul E, Feinberg, Andrew P

“…Genomic imprinting, or parental allele-specific expression of genes, has been demonstrated at the molecular level in insects and mice but not in man…”
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Two Novel Genes in the Center of the 11p15 Imprinted Domain Escape Genomic Imprinting by Lee, Maxwell P., Brandenburg, Sheri, Landes, Gregory M., Adams, Mark, Miller, Glenn, Feinberg, Andrew P.

“…We previously reported the isolation of a 2.5 Mb tumor-suppressing subchromosomal transferable fragment (STF) from human chromosome 11p15 and the…”
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Syntenic Organization of the Mouse Distal Chromosome 7 Imprinting Cluster and the Beckwith-Wiedemann Syndrome Region in Chromosome 11p15.5 by Paulsen, Martina, Davies, Karen R., Bowden, Lucy M., Villar, Angela J., Franck, Olivia, Fuermann, Martina, Dean, Wendy L., Moore, Tom F., Rodrigues, Nanda, Davies, Kay E., Hu, Ren-J., Feinberg, Andrew P., Maher, Eamonn R., Reik, Wolf, Walter, Jörn

“…In human and mouse, most imprinted genes are arranged in chromosomal clusters. Their linked organization suggests co-ordinated mechanisms controlling…”
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Aberrant splicing but not mutations of TSG101 in human breast cancer by LEE, M. P, FEINBERG, A. P

“…The 11p15 gene TSG101 was recently reported to undergo frequent large intragenic deletions in human breast cancer. Here we show that that is generally not the…”
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Loss of allelic heterozygosity at a second locus on chromosome 11 in sporadic Wilms' tumor cells by REEVE, A. E, SIH, S. A, RAIZIS, A. M, FEINBERG, A. P

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