Search Results - "Feil, R"

Function of cGMP-Dependent Protein Kinases as Revealed by Gene Deletion by Hofmann, F, Feil, R, Kleppisch, T, Schlossmann, J

“…Institut für Pharmakologie und Toxikologie, TU München, München, Germany Over the past few years, a wealth of biochemical and functional data have been…”
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Conditional somatic mutagenesis in the mouse using site-specific recombinases by Feil, R

“…In the last decade, site-specific recombinases (SSRs), such as Cre and Flp, have emerged as indispensable tools for the precise in vivo manipulation of the…”
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Child Health, Developmental Plasticity, and Epigenetic Programming by Hochberg, Z, Feil, R, Constancia, M, Fraga, M, Junien, C, Carel, J.-C, Boileau, P, Le Bouc, Y, Deal, C. L, Lillycrop, K, Scharfmann, R, Sheppard, A, Skinner, M, Szyf, M, Waterland, R. A, Waxman, D. J, Whitelaw, E, Ong, K, Albertsson-Wikland, K

“…Plasticity in developmental programming has evolved to provide the best chances of survival and reproductive success to the organism under changing…”
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Imprinted gene expression in hybrids: perturbed mechanisms and evolutionary implications by Wolf, J B, Oakey, R J, Feil, R

“…Diverse mechanisms contribute to the evolution of reproductive barriers, a process that is critical in speciation. Amongst these are alterations in gene…”
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Genomic imprinting in the placenta by Wagschal, A, Feil, R

“…Genomic imprinting is an epigenetic mechanism that is important for the development and function of the extra-embryonic tissues in the mouse. Remarkably all…”
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Limited Evolutionary Conservation of Imprinting in the Human Placenta by Monk, D., Arnaud, P., Apostolidou, S., Hills, F. A., Kelsey, G., Stanier, P., Feil, R., Moore, G. E.

“…The epigenetic phenomenon of genomic imprinting provides an additional level of gene regulation that is confined to a limited number of genes, frequently, but…”
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Cerebellar Ataxia and Purkinje Cell Dysfunction Caused by Ca2+-Activated K+Channel Deficiency by Sausbier, M., Hu, H., Arntz, C., Feil, S., Kamm, S., Adelsberger, H., Sausbier, U., Sailer, C. A., Feil, R., Hofmann, F., Korth, M., Shipston, M. J., H.-G. Knaus, Wolfer, D. P., Pedroarena, C. M., Storm, J. F., Ruth, P., Andersen, Per O.

“…Malfunctions of potassium channels are increasingly implicated as causes of neurological disorders. However, the functional roles of the large-conductance…”
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C21 Genomic imprinting: about germ cells and maintenance of epigenetic information by Feil, R

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Culture of Preimplantation Mouse Embryos Affects Fetal Development and the Expression of Imprinted Genes by KHOSLA, Sanjeev, DEAN, Wendy, BROWN, David, REIK, Wolf, FEIL, Robert

“…Culture of preimplantation mammalian embryos and cells can influence their subsequent growth and differentiation. Previously, we reported that culture of mouse…”
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Ligand-Activated Site-Specific Recombination in Mice by Feil, R., Brocard, J., Mascrez, B., LeMeur, M., Metzger, D., Chambon, P.

“…Current mouse gene targeting technology is unable to introduce somatic mutations at a chosen time and/or in a given tissue. We report here that conditional…”
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Genomic imprinting in mammals: an interplay between chromatin and DNA methylation? by Feil, Robert, Khosla, Sanjeev

“…Most imprinted loci have key regulatory elements that are methylated on only one of the parental chromosomes. For several of these ‘differentially methylated…”
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Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients by Welter, H., Kampfer, C., Lauf, S., Feil, R., Schwarzer, J. U., Köhn, F.‐M., Mayerhofer, A.

“…Summary Fibrotic remodelling of the testicular tubular wall is common in human male infertility caused by impaired spermatogenesis. We hypothesized that this…”
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Multiple Imprinted Sense and Antisense Transcripts, Differential Methylation and Tandem Repeats in a Putative Imprinting Control Region Upstream of Mouse Igf2 by Moore, T., Constancia, M., Zubair, M., Bailleul, B., Feil, R., Sasaki, H., Reik, W.

“…The mouse insulin-like growth factor 2 (Igf2) locus is a complex genomic region that produces multiple transcripts from alternative promoters. Expression at…”
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Distribution of cGMP-dependent protein kinase type I and its isoforms in the mouse brain and retina by Feil, S., Zimmermann, P., Knorn, A., Brummer, S., Schlossmann, J., Hofmann, F., Feil, R.

“…Nitric oxide (NO) modulates a variety of processes in the mammalian brain, but the mechanisms of neuronal NO signaling are poorly understood. In the periphery,…”
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The German Cartilage Registry (KnorpelRegister DGOU) for evaluation of surgical treatment for cartilage defects: experience after six months including first demographic data by Niemeyer, P, Schweigler, K, Grotejohann, B, Maurer, J, Angele, P, Aurich, M, Becher, C, Fay, J, Feil, R, Fickert, S, Fritz, J, Hoburg, A, Kreuz, P, Kolombe, T, Laskowski, J, Lützner, J, Marlovits, S, Müller, P E, Niethammer, T, Pietschmann, M, Ruhnau, K, Spahn, G, Tischer, T, Zinser, W, Albrecht, D

“…The German Cartilage Registry (KnorpelRegister DGOU) has been introduced in October 2013 and aims on the evaluation of patients who underwent cartilage repair…”
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Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes by Dean, W, Bowden, L, Aitchison, A, Klose, J, Moore, T, Meneses, J J, Reik, W, Feil, R

“…In vitro manipulation of preimplantation mammalian embryos can influence differentiation and growth at later stages of development. In the mouse, culture of…”
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Expansion dynamics, metabolite composition and substance transfer of the primary root growth zone of Zea mays L. grown in different external nutrient availabilities by WALTER, A., FEIL, R., SCHURR, U.

“…ABSTRACT A combined analysis of growth and metabolite composition was performed in primary roots of Zea mays L. (Var. Alexander). The seedlings were…”
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Leaf development in Ricinus communis during drought stress: dynamics of growth processes, of cellular structure and of sink–source transition by Schurr, U., Heckenberger, U., Herdel, K., Walter, A., Feil, R.

“…Dicot leaf growth is characterized by partly transient tip‐to‐base gradients of growth processes, structure and function. These gradients develop dynamically…”
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Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death by Boesten, L S M, Zadelaar, S M, De Clercq, S, Francoz, S, van Nieuwkoop, A, Biessen, E A L, Hofmann, F, Feil, S, Feil, R, Jochemsen, A G, Zurcher, C, Havekes, L M, van Vlijmen, B J M, Marine, J-C

“…p53 is a potent inhibitor of cell growth and an inducer of apoptosis. During embryonic development, Mdm2 and Mdm4 inhibit the growth suppressive activities of…”
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Upregulation of non-β cell-derived vascular endothelial growth factor A increases small clusters of insulin-producing cells in the pancreas by Takenouchi, K, Shrestha, B, Yamakuchi, M, Yoshinaga, N, Arimura, N, Kawaguchi, H, Nagasato, T, Feil, R, Kawahara, K, Sakamoto, T, Maruyama, I, Hashiguchi, T

“…Pancreatic β cell-derived vascular endothelial growth factor A (VEGF-A) contributes to normal β cell function. We therefore hypothesized that non-β…”
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