Search Results - "Fehsel, K"

Comorbidity of osteoporosis and Alzheimer’s disease: Is `AKT `-ing on cellular glucose uptake the missing link? by Fehsel, K., Christl, J.

“…Osteoporosis and Alzheimer’s disease (AD) are both degenerative diseases. Osteoporosis often proceeds cognitive deficits, and multiple studies have revealed…”
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Activation of the aryl hydrocarbon receptor by clozapine induces preadipocyte differentiation and contributes to endothelial dysfunction by Fehsel, K, Schwanke, K, Kappel, BA, Fahimi, E, Meisenzahl-Lechner, E, Esser, C, Hemmrich, K, Haarmann-Stemmann, T, Kojda, G, Lange-Asschenfeldt, C

“…Background: The superior therapeutic benefit of clozapine is often associated with metabolic disruptions as obesity, insulin resistance, tachycardia, higher…”
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Inducible nitric oxide synthase in human diseases by KRONCKE, K.-D, FEHSEL, K, KOLB-BACHOFEN, V

“…Since its discovery as a biologically active molecule in the late 1980s, nitric oxide (NO) has been found to play an important role as signal molecule in many…”
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Gene-environment Interaction Between Estrogen Receptor (ER) SS, ApoE and Air Pollution On Cognitive Performance in an Elderly, Female Cohort by Luckhaus, C, Schikowski, T, Vossoughi, M, Vierkötter, A, Krämer, U, Herder, C, Fehsel, K

“…Introduction In the brain, estrogen plays an important role in neural plasticity and its decline during menopause might result in cognitive impairment and…”
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Clozapine enhances differentiation of adipocyte progenitor cells by Hemmrich, K, Gummersbach, C, Pallua, N, Luckhaus, C, Fehsel, K

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Islet cell DNA is a target of inflammatory attack by nitric oxide by Fehsel, K., Jalowy, A., Qi, S., Burkart, V., Hartmann, B., Kolb, H.

“…Islet cell DNA is a target of inflammatory attack by nitric oxide. K Fehsel , A Jalowy , S Qi , V Burkart , B Hartmann and H Kolb Diabetes Research Institute,…”
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Inactivation of the Poly(ADP-ribose) Polymerase Gene Affects Oxygen Radical and Nitric Oxide Toxicity in Islet Cells by Heller, Birgit, Wang, Zhao-Qi, Wagner, Erwin F., Radons, Jürgen, Bürkle, Alexander, Fehsel, Karin, Burkart, Volker, Kolb, Hubert

“…Activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) is an early response of cells exposed to DNA-damaging compounds such as nitric oxide (NO)…”
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Nitric oxide induces apoptosis in mouse thymocytes by Fehsel, K, Kroncke, KD, Meyer, KL, Huber, H, Wahn, V, Kolb-Bachofen, V

“…Nitric oxide (NO) produced at high concentrations by the inducible NO synthase is an important effector molecule involved in immune regulation and defense. We…”
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Nitric oxide destroys zinc-sulfur clusters inducing zinc release from metallothionein and inhibition of the zinc finger-type yeast transcription activator LAC9 by Kröncke, K D, Fehsel, K, Schmidt, T, Zenke, F T, Dasting, I, Wesener, J R, Bettermann, H, Breunig, K D, Kolb-Bachofen, V

“…Nitric oxide, generated from S-nitrosocysteine or applied as gas mediates metal ion release from the Zn2+/Cd(2+)-complexing protein metallothionein via…”
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A proinflammatory activity of interleukin 8 in human skin: expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes by Bruch-Gerharz, D, Fehsel, K, Suschek, C, Michel, G, Ruzicka, T, Kolb-Bachofen, V

“…Psoriasis is a common chronic skin disease mediated by cellular immune mechanisms and characterized by an intense neutrophil cell infiltrate and proliferative…”
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Aldosterone resistance in kidney transplantation is in part induced by a down-regulation of mineralocorticoid receptor expression by Heering, PJ, Kurschat, C, Vo, DT, Klein-Vehne, N, Fehsel, K, Ivens, K

“…After renal transplantation immunosuppressive drugs-like cyclosporin A (CsA) and FK506 induce either hypoaldosteronism or pseudo-hypoaldosteronism presenting…”
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Decreased mineralocorticoid receptor expression in blood cells of kidney transplant recipients undergoing immunosuppressive treatment: cost efficient determination by quantitative PCR by Heering, P J, Klein-Vehne, N, Fehsel, K

“…Aims: Electrolyte imbalances caused by impaired ion transport are a frequent side effect of immunosuppressive treatment in renal transplant recipients…”
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Endothelial cells as cytotoxic effector cells : cytokine-activated rat islet endothelial cells lyse syngeneic islet cells via nitric oxide by STEINER, L, KRÖNCKE, K.-D, FEHSEL, K, KOLB-BACHOFEN, V

“…In vivo, each beta cell is located in proximity to at least one capillary islet endothelial cell. Rat aorta and islet endothelial cells can be activated in…”
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Analysis of TNF alpha-induced DNA strand breaks at the single cell level by Fehsel, K, Kolb-Bachofen, V, Kolb, H

“…Treatment of L929 cells with TNF alpha initiates apoptosis and subsequent cell death. The authors have visualized sites of DNA damage in situ by using DNA…”
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Primary cultures of rat islet capillary endothelial cells. Constitutive and cytokine-inducible macrophagelike nitric oxide synthases are expressed and activities regulated by glucose concentration by Suschek, C, Fehsel, K, Kroncke, KD, Sommer, A, Kolb-Bachofen, V

“…We have succeeded in obtaining cultures of pure rat islet capillary endothelial cells. These multiply in vitro and exhibit the same antigenic phenotype as…”
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Induction of a macrophage-like nitric oxide synthase in cultured rat aortic endothelial cells. IL-1 beta-mediated induction regulated by tumor necrosis factor-alpha and IFN-gamma by Suschek, C, Rothe, H, Fehsel, K, Enczmann, J, Kolb-Bachofen, V

“…We investigated the effects of murine rTNF-alpha, human rIL-1 beta, and rat rIFN-gamma in various concentrations and/or combinations on inducible nitric oxide…”
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Increased apoptosis of neutrophils in a case of clozapine-induced agranulocytosis - a case report by Loeffler, S, Fehsel, K, Henning, U, Fischer, J, Agelink, M, Kolb-Bachofen, V, Klimke, A

“…A 45-year-old female suffering from severe chronic schizophrenia of the paranoid type did not respond to typical antipsychotics. Five weeks after starting…”
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Effects of the genetic polymorphisms of the renin-angiotensin system on focal segmental glomerulosclerosis by Luther, Y, Bantis, C, Ivens, K, Fehsel, K, Kolb-Bachhofen, V, Heering, P

“…We analyzed the influence of angiotensin-converting enzyme (ACE) I/D, angiotensinogen (AGT) M235T and angiotensin-II-type-1 receptor (AT1R) A1166C genetic…”
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In situ nick-translation detects focal apoptosis in thymuses of glucocorticoid- and lipopolysaccharide-treated mice by Fehsel, K, Kroncke, KD, Kolb, H, Kolb-Bachofen, V

“…In this study we used in situ nick-translation to analyze apoptotic events in the thymus and in cultured thymocytes at the level of individual cell nuclei. In…”
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Tumour necrosis factor alpha production is upregulated in diabetes prone BB rats by ROTHE, H, FEHSEL, K, KOLB, H

“…Following activation peritoneal macrophages from diabetes prone BB rats secreted strikingly higher amounts of tumour necrosis factor alpha than found for…”
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