Search Results - "Fehrmann, Steffen"

Aging Yeast Cells Undergo a Sharp Entry into Senescence Unrelated to the Loss of Mitochondrial Membrane Potential by Fehrmann, Steffen, Paoletti, Camille, Goulev, Youlian, Ungureanu, Andrei, Aguilaniu, Hugo, Charvin, Gilles

“…In budding yeast, a mother cell can produce a finite number of daughter cells before it stops dividing and dies. Such entry into senescence is thought to…”
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Two routes to senescence revealed by real-time analysis of telomerase-negative single lineages by Xu, Zhou, Fallet, Emilie, Paoletti, Camille, Fehrmann, Steffen, Charvin, Gilles, Teixeira, Maria Teresa

“…In eukaryotes, telomeres cap chromosome ends to maintain genomic stability. Failure to maintain telomeres leads to their progressive erosion and eventually…”
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Cell-to-cell stochastic variation in gene expression is a complex genetic trait by Ansel, Juliet, Bottin, Hélène, Rodriguez-Beltran, Camilo, Damon, Christelle, Nagarajan, Muniyandi, Fehrmann, Steffen, François, Jean, Yvert, Gaël

“…The genetic control of common traits is rarely deterministic, with many genes contributing only to the chance of developing a given phenotype. This incomplete…”
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Natural sequence variants of yeast environmental sensors confer cell‐to‐cell expression variability by Fehrmann, Steffen, Bottin‐Duplus, Hélène, Leonidou, Andri, Mollereau, Esther, Barthelaix, Audrey, Wei, Wu, Steinmetz, Lars M, Yvert, Gaël

“…Living systems may have evolved probabilistic bet hedging strategies that generate cell‐to‐cell phenotypic diversity in anticipation of environmental…”
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Natural single-nucleosome epi-polymorphisms in yeast by Nagarajan, Muniyandi, Veyrieras, Jean-Baptiste, de Dieuleveult, Maud, Bottin, Hélène, Fehrmann, Steffen, Abraham, Anne-Laure, Croze, Séverine, Steinmetz, Lars M, Gidrol, Xavier, Yvert, Gaël

“…Epigenomes commonly refer to the sequence of presence/absence of specific epigenetic marks along eukaryotic chromatin. Complete histone-borne epigenomes have…”
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Structural analysis of random transgene integration in CHO manufacturing cell lines by targeted sequencing by Stadermann, Anna, Gamer, Martin, Fieder, Jürgen, Lindner, Benjamin, Fehrmann, Steffen, Schmidt, Moritz, Schulz, Patrick, Gorr, Ingo H.

“…Genetically modified CHO cell lines are traditionally used for the production of biopharmaceuticals. However, an in‐depth molecular understanding of the…”
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Microbiome dynamics and adaptation of expression signatures during methane production failure and process recovery by Grohmann, Anja, Fehrmann, Steffen, Vainshtein, Yevhen, Haag, Nicola L., Wiese, Franziska, Stevens, Philip, Naegele, Hans-Joachim, Oechsner, Hans, Hartsch, Thomas, Sohn, Kai, Grumaz, Christian

“…•Substrate and temperature specific groups of microbes identified.•Methanoculleus sp. Eu01 impaired in hydrogenotrophic pathway by low temperature.•Recovery…”
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Single-cell phenomics reveals intra-species variation of phenotypic noise in yeast by Yvert, Gaël, Ohnuki, Shinsuke, Nogami, Satoru, Imanaga, Yasutaka, Fehrmann, Steffen, Schacherer, Joseph, Ohya, Yoshikazu

“…Most quantitative measures of phenotypic traits represent macroscopic contributions of large numbers of cells. Yet, cells of a tissue do not behave similarly,…”
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Finding modulators of stochasticity levels by quantitative genetics by Fehrmann, Steffen, Yvert, Gaël

“…Although bakers and wine makers constantly select, compare, and hunt for new wild strains of Saccharomyces cerevisiae, yeast geneticists have long focused on a…”
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Single-cell phenomics reveals intra-species variation of phenotypic noise in yeast by Yvert, Gaël, Ohnuki, Shinsuke, Nogami, Satoru, Imanaga, Yasutaka, Fehrmann, Steffen, Schacherer, Joseph, Ohya, Yoshikazu

“…Background Most quantitative measures of phenotypic traits represent macroscopic contributions of large numbers of cells. Yet, cells of a tissue do not behave…”
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A New Integrated Knowledge Management & Data Analysis Platform for Cell Line Development & Cell Culture R&D by Niklas, Jens, Retey, Julia, Fehrmann, Steffen, Macko, Ludwig, Hartsch, Thomas, Adamczyk, Ben

“…New technologies such as next generation sequencing (NGS) and -omics have changed the way in which cell line development, cell line engineering and cell…”
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A biophysical approach to the optimisation of dendritic-tumour cell electrofusion by Sukhorukov, Vladimir L., Reuss, Randolph, Endter, Jörg M., Fehrmann, Steffen, Katsen-Globa, Alisa, Geßner, Petra, Steinbach, Andrea, Müller, Kilian J., Karpas, Abraham, Zimmermann, Ulrich, Zimmermann, Heiko

“…Electrofusion of tumour and dendritic cells (DCs) is a promising approach for production of DC-based anti-tumour vaccines. Although human DCs are well…”
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Natural Single-Nucleosome Epi-Polymorphisms in Yeast: e1000913 by Nagarajan, Muniyandi, Veyrieras, Jean-Baptiste, Dieuleveult, Maud de, Bottin, Hélène, Fehrmann, Steffen, Abraham, Anne-Laure, Croze, Séverine, Steinmetz, Lars M, Gidrol, Xavier, Yvert, Gaël

“…Epigenomes commonly refer to the sequence of presence/absence of specific epigenetic marks along eukaryotic chromatin. Complete histone-borne epigenomes have…”
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Cell-to-Cell Stochastic Variation in Gene Expression Is a Complex Genetic Trait: e1000049 by Ansel, Juliet, Bottin, Hélène, Rodriguez-Beltran, Camilo, Damon, Christelle, Nagarajan, Muniyandi, Fehrmann, Steffen, François, Jean, Yvert, Gaël

“…The genetic control of common traits is rarely deterministic, with many genes contributing only to the chance of developing a given phenotype. This incomplete…”
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