Search Results - "Fehringer, Gordon"

Impact of Circulating Tumor DNA-Based Detection of Molecular Residual Disease on the Conduct and Design of Clinical Trials for Solid Tumors by Kasi, Pashtoon M, Fehringer, Gordon, Taniguchi, Hiroya, Starling, Naureen, Nakamura, Yoshiaki, Kotani, Daisuke, Powles, Thomas, Li, Bob T, Pusztai, Lajos, Aushev, Vasily N, Kalashnikova, Ekaterina, Sharma, Shruti, Malhotra, Meenakshi, Demko, Zachary P, Aleshin, Alexey, Rodriguez, Angel, Billings, Paul R, Grothey, Axel, Taieb, Julien, Cunningham, David, Yoshino, Takayuki, Kopetz, Scott

“…Earlier detection of cancer recurrence using circulating tumor DNA (ctDNA) to detect molecular residual disease (MRD) has the potential to dramatically affect…”
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A two-dimensional pooling strategy for rare variant detection on next-generation sequencing platforms by Zuzarte, Philip C, Denroche, Robert E, Fehringer, Gordon, Katzov-Eckert, Hagit, Hung, Rayjean J, McPherson, John D

“…We describe a method for pooling and sequencing DNA from a large number of individual samples while preserving information regarding sample identity. DNA from…”
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Comparison of pathway analysis approaches using lung cancer GWAS data sets by Fehringer, Gordon, Liu, Geoffrey, Briollais, Laurent, Brennan, Paul, Amos, Christopher I, Spitz, Margaret R, Bickeböller, Heike, Wichmann, H Erich, Risch, Angela, Hung, Rayjean J

“…Pathway analysis has been proposed as a complement to single SNP analyses in GWAS. This study compared pathway analysis methods using two lung cancer GWAS data…”
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Clinical Validation of a Plasma Donor-derived Cell-free DNA Assay to Detect Allograft Rejection and Injury in Lung Transplant by Rosenheck, Justin P., Ross, David J., Botros, Mena, Wong, Alexander, Sternberg, Jonathan, Chen, Yen-An, Liang, Nathan, Baer, Amy, Ahmed, Ebad, Swenerton, Ryan, Zimmermann, Bernhard G., Fehringer, Gordon, Demko, Zachary P., Olymbios, Michael, Billings, Paul R., Keller, Brian C.

“…Lung transplant patients are vulnerable to various forms of allograft injury, whether from acute rejection (AR) (encompassing acute cellular rejection [ACR]…”
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Modernization of Record Linkage At ICES by Azimaee, Mahmoud, Chong, Nelson, Ma, Charlotte, Fehringer, Gordon, Kalappa, Gangamma, Wang, Nan, Qian, Cheng, Vermeulen, Marian

“…IntroductionProbabilistic Record Linkage of large databases requires a substantial amount of time and resources, resulting in significant costs. In addition,…”
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META-GSA: Combining Findings from Gene-Set Analyses across Several Genome-Wide Association Studies by Rosenberger, Albert, Friedrichs, Stefanie, Amos, Christopher I, Brennan, Paul, Fehringer, Gordon, Heinrich, Joachim, Hung, Rayjean J, Muley, Thomas, Müller-Nurasyid, Martina, Risch, Angela, Bickeböller, Heike

“…Gene-set analysis (GSA) methods are used as complementary approaches to genome-wide association studies (GWASs). The single marker association estimates of a…”
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Family-based association study of IGF1 microsatellites and height, weight, and body mass index by Fehringer, Gordon, Ozcelik, Hilmi, Knight, Julia A, Paterson, Andrew D, Dite, Gillian S, Giles, Graham G, Southey, Melissa C, Andrulis, Irene L, Hopper, John L, Boyd, Norman F

“…Height, weight, and body mass index (BMI) are partly heritable, known to be associated with chronic diseases, and are linked to circulating insulin-like growth…”
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Using both the Fraction and Quantity of Donor-Derived Cell-Free DNA to Detect Kidney Allograft Rejection by Bunnapradist, Suphamai, Homkrailas, Piyavadee, Ahmed, Ebad, Fehringer, Gordon, Billings, Paul R, Tabriziani, Hossein

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Sensitive tumour detection and classification using plasma cell-free DNA methylomes by Shen, Shu Yi, Singhania, Rajat, Fehringer, Gordon, Chakravarthy, Ankur, Roehrl, Michael H. A., Chadwick, Dianne, Zuzarte, Philip C., Borgida, Ayelet, Wang, Ting Ting, Li, Tiantian, Kis, Olena, Zhao, Zhen, Spreafico, Anna, Medina, Tiago da Silva, Wang, Yadon, Roulois, David, Ettayebi, Ilias, Chen, Zhuo, Chow, Signy, Murphy, Tracy, Arruda, Andrea, O’Kane, Grainne M., Liu, Jessica, Mansour, Mark, McPherson, John D., O’Brien, Catherine, Leighl, Natasha, Bedard, Philippe L., Fleshner, Neil, Liu, Geoffrey, Minden, Mark D., Gallinger, Steven, Goldenberg, Anna, Pugh, Trevor J., Hoffman, Michael M., Bratman, Scott V., Hung, Rayjean J., De Carvalho, Daniel D.

“…The use of liquid biopsies for cancer detection and management is rapidly gaining prominence 1 . Current methods for the detection of circulating tumour DNA…”
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A novel donor-derived cell-free DNA assay for the detection of acute rejection in heart transplantation by Kim, Paul J., Olymbios, Michael, Siu, Alfonso, Wever Pinzon, Omar, Adler, Eric, Liang, Nathan, Swenerton, Ryan, Sternberg, Jonathan, Kaur, Navchetan, Ahmed, Ebad, Chen, Yen-An, Fehringer, Gordon, Demko, Zachary P., Billings, Paul R., Stehlik, Josef

“…Endomyocardial biopsy (EMB), the reference surveillance test for acute rejection (AR) in heart transplant (HTx) recipients, is invasive, costly, and shows…”
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Abstract 569: Correlation of variant allele frequency and mean tumor molecules with tumor burden in patients with solid tumors by Tin, Antony, Aushev, Vasily, Kalashnikova, Ekaterina, Salari, Raheleh, Shchegrova, Svetalana, Fehringer, Gordon, Malhotra, Meenakshi, Ravi, Harini, Sethi, Himanshu, Brevnov, Maxim, Zimmermann, Bernhard, Rodriguez, Angel, Billings, Paul R., Aleshin, Alexey

“…Abstract Introduction: Two metrics are commonly used to quantify tumor-specific variants in cell-free DNA (cfDNA): the variant allele frequency (VAF), defined…”
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427.5: Clinical Validation of a Plasma Donor-Derived Cell-Free DNA Assay to Detect Allograft Rejection and Injury in Lung Transplant by Rosenheck, Justin P., Ross, David J., Botros, Mena, Wong, Alexander, Sternberg, Jonathan, Chen, Yen-An, Liang, Nathan, Baer, Amy, Ahmed, Ebad, Swenerton, Ryan K., Zimmermann, Bernhard G., Fehringer, Gordon, Demko, Zachary P., Olymbios, Michael, Escrig, Cesar, Billings, Paul R., Keller, Brian C.

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Incorporation of Donor-derived Cell-free DNA Into Clinical Practice for Renal Allograft Management by Qazi, Yasir, Patel, Anup, Fajardo, Mark, McCormick, Sarah, Fehringer, Gordon, Ahmed, Ebad, Malhotra, Meenakshi, Demko, Zachary P., Billings, Paul R., Tabriziani, Hossein, Gauthier, Philippe

“…•Donor-derived cell-free DNA (dd-cfDNA) is a validated biomarker for active rejection (AR).•We investigated how dd-cfDNA may impact biopsy decisions in renal…”
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Association Between Total Cell Free DNA and SARS-CoV-2 In Kidney Transplant Patients: A Preliminary Study by Reusing, Jose Otto, Yoo, Jongwon, Desai, Amishi, Brossart, Katya, McCormick, Sarah, Malashevich, Allyson Koyen, Bloom, Michelle S., Fehringer, Gordon, White, Roseann, Billings, Paul R., Tabriziani, Hossein, Demko, Zachary P., Gauthier, Philippe, Akkina, Sanjeev K., David-Neto, Elias

“…Kidney transplant (KT) recipients are at high risk for developing severe COVID-19. Lowering immunosuppression levels in KT recipients with COVID-19 encourages…”
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Cancer Incidence and Mortality in Northeastern Ontario, 1991-1998 by Conlon, Michael S.C., Lightfoot, Nancy E., Bissett, Randy J., Fehringer, Gordon M.

“…Background: This descriptive epidemiology study reports the cancer incidence and mortality experience of Northeastern Ontario residents during the 8-year…”
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Cross-Cancer Analysis Reveals Novel Pleiotropic Associations-Response by Hung, Rayjean J, Fehringer, Gordon, Casey, Graham, Gruber, Stephen B, Peters, Ulrike, Goode, Ellen L, Sellers, Thomas A, Haiman, Christopher A, Hunter, David J, Kraft, Peter, Amos, Christopher I, Freedman, Matthew L, Wilson, Michael D

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The association of family history of cancer and medical history with pancreatic cancer risk by Fehringer, Gordon, Gallinger, Steven, Borgida, Ayelet, Zhang, Li Rita, Adams, Laura, Liu, Geoffrey, Hung, Rayjean J

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Abstract 4810: Family history of cancers, medical history, and pancreatic cancer risk in the Ontario Pancreatic Cancer Case-Control Study by Fehringer, Gordon, Gallinger, Steven, Borgida, Ayelet, Zhang, Li Rita, Liu, Geoffrey, Hung, Rayjean J.

“…Abstract Background: Pancreatic cancer is one of the most fatal cancers. Given the high mortality burden of this disease, there is a pressing need to determine…”
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Identification of shared and unique susceptibility pathways among cancers of the lung, breast, and prostate from genome-wide association studies and tissue-specific protein interactions by Qian, David C, Byun, Jinyoung, Han, Younghun, Greene, Casey S, Field, John K, Hung, Rayjean J, Brhane, Yonathan, Mclaughlin, John R, Fehringer, Gordon, Landi, Maria Teresa, Rosenberger, Albert, Bickeböller, Heike, Malhotra, Jyoti, Risch, Angela, Heinrich, Joachim, Hunter, David J, Henderson, Brian E, Haiman, Christopher A, Schumacher, Fredrick R, Eeles, Rosalind A, Easton, Douglas F, Seminara, Daniela, Amos, Christopher I

“…Results from genome-wide association studies (GWAS) have indicated that strong single-gene effects are the exception, not the rule, for most diseases. We…”
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Abstract 817: Mendelian randomization and mediation analysis of 5p15.33, telomere length and lung cancer risk by Kachuri, Linda, Davey Smith, George, Liu, Geoffrey, Landi, Maria Teresa, Christiani, David C., Caporaso, Neil E., McKay, James D., Wu, Xifeng, Aldrich, Melinda C., Rennert, Gad, Teare, Dawn, Chen, Chu, Goodman, Gary E., Doherty, Jennifer A., Field, John K., Kiemeney, Lambertus A., Tardón, Adonina, Haugen, Aage, Lam, Stephen, Le Marchand, Loic, Schabath, Matthew B., Andrew, Angeline S., Johansson, Mattias, Manjer, Jonas, Lazarus, Philip, Arnold, Susanne, Fehringer, Gordon, Zong, Xuchen, Brennan, Paul, Bojesen, Stig E., Amos, Christopher I., Hung, Rayjean J.

“…Abstract Background: Telomere length (TL) is a predictor of lung cancer risk, but the direction of this association differs between and prospective and…”
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