Search Results - "Fehniger, Todd A."

Allogeneic natural killer cell therapy by Berrien-Elliott, Melissa M., Jacobs, Miriam T., Fehniger, Todd A.

“…[Display omitted] Interest in adoptive cell therapy for treating cancer is exploding owing to early clinical successes of autologous chimeric antigen receptor…”
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Cytokine activation induces human memory-like NK cells by Romee, Rizwan, Schneider, Stephanie E., Leong, Jeffrey W., Chase, Julie M., Keppel, Catherine R., Sullivan, Ryan P., Cooper, Megan A., Fehniger, Todd A.

“…Natural killer (NK) cells are lymphocytes that play an important role in the immune response to infection and malignancy. Recent studies in mice have shown…”
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Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia by Romee, Rizwan, Rosario, Maximillian, Berrien-Elliott, Melissa M, Wagner, Julia A, Jewell, Brea A, Schappe, Timothy, Leong, Jeffrey W, Abdel-Latif, Sara, Schneider, Stephanie E, Willey, Sarah, Neal, Carly C, Yu, Liyang, Oh, Stephen T, Lee, Yi-Shan, Mulder, Arend, Claas, Frans, Cooper, Megan A, Fehniger, Todd A

“…Natural killer (NK) cells are an emerging cellular immunotherapy for patients with acute myeloid leukemia (AML); however, the best approach to maximize NK cell…”
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First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation by Romee, Rizwan, Cooley, Sarah, Berrien-Elliott, Melissa M., Westervelt, Peter, Verneris, Michael R., Wagner, John E., Weisdorf, Daniel J., Blazar, Bruce R., Ustun, Celalettin, DeFor, Todd E., Vivek, Sithara, Peck, Lindsey, DiPersio, John F., Cashen, Amanda F., Kyllo, Rachel, Musiek, Amy, Schaffer, András, Anadkat, Milan J., Rosman, Ilana, Miller, Daniel, Egan, Jack O., Jeng, Emily K., Rock, Amy, Wong, Hing C., Fehniger, Todd A., Miller, Jeffrey S.

“…New therapies for patients with hematologic malignancies who relapse after allogeneic hematopoietic cell transplantation (allo-HCT) are needed. Interleukin 15…”
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Single-agent ibrutinib in relapsed or refractory follicular lymphoma: a phase 2 consortium trial by Bartlett, Nancy L., Costello, Brian A., LaPlant, Betsy R., Ansell, Stephen M., Kuruvilla, John G., Reeder, Craig B., Thye, Lim S., Anderson, Daniel M., Krysiak, Kilannin, Ramirez, Cody, Qi, Jing, Siegel, Barry A., Griffith, Malachi, Griffith, Obi L., Gomez, Felicia, Fehniger, Todd A.

“…Most patients with follicular lymphoma (FL) experience multiple relapses necessitating subsequent lines of therapy. Ibrutinib, a Bruton tyrosine kinase (BTK)…”
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CD56bright NK cells exhibit potent antitumor responses following IL-15 priming by Wagner, Julia A, Rosario, Maximillian, Romee, Rizwan, Berrien-Elliott, Melissa M, Schneider, Stephanie E, Leong, Jeffrey W, Sullivan, Ryan P, Jewell, Brea A, Becker-Hapak, Michelle, Schappe, Timothy, Abdel-Latif, Sara, Ireland, Aaron R, Jaishankar, Devika, King, Justin A, Vij, Ravi, Clement, Dennis, Goodridge, Jodie, Malmberg, Karl-Johan, Wong, Hing C, Fehniger, Todd A

“…NK cells, lymphocytes of the innate immune system, are important for defense against infectious pathogens and cancer. Classically, the CD56dim NK cell subset…”
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Recurrent somatic mutations affecting B-cell receptor signaling pathway genes in follicular lymphoma by Krysiak, Kilannin, Gomez, Felicia, White, Brian S., Matlock, Matthew, Miller, Christopher A., Trani, Lee, Fronick, Catrina C., Fulton, Robert S., Kreisel, Friederike, Cashen, Amanda F., Carson, Kenneth R., Berrien-Elliott, Melissa M., Bartlett, Nancy L., Griffith, Malachi, Griffith, Obi L., Fehniger, Todd A.

“…Follicular lymphoma (FL) is the most common form of indolent non-Hodgkin lymphoma, yet it remains only partially characterized at the genomic level. To improve…”
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Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development by Dege, Carissa, Fegan, Katherine H., Creamer, J. Philip, Berrien-Elliott, Melissa M., Luff, Stephanie A., Kim, Darren, Wagner, Julia A., Kingsley, Paul D., McGrath, Kathleen E., Fehniger, Todd A., Palis, James, Sturgeon, Christopher M.

“…Natural killer (NK) cells are a critical component of the innate immune system. However, their ontogenic origin has remained unclear. Here, we report that NK…”
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Blood natural killer cell deficiency reveals an immunotherapy strategy for atopic dermatitis by Mack, Madison R, Brestoff, Jonathan R, Berrien-Elliott, Melissa M, Trier, Anna M, Yang, Ting-Lin B, McCullen, Matthew, Collins, Patrick L, Niu, Haixia, Bodet, Nancy D, Wagner, Julia A, Park, Eugene, Xu, Amy Z, Wang, Fang, Chibnall, Rebecca, Council, M Laurin, Heffington, Carrie, Kreisel, Friederike, Margolis, David J, Sheinbein, David, Lovato, Paola, Vivier, Eric, Cella, Marina, Colonna, Marco, Yokoyama, Wayne M, Oltz, Eugene M, Fehniger, Todd A, Kim, Brian S

“…Atopic dermatitis (AD) is a widespread, chronic skin disease associated with aberrant allergic inflammation. Current treatments involve either broad or…”
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microRNA management of NK‐cell developmental and functional programs by Leong, Jeffrey W., Sullivan, Ryan P., Fehniger, Todd A.

“…NK cells are innate lymphoid cells that are critical for host defense against infection, and mediate anti‐tumor responses. MicroRNAs (miRNAs) are a large…”
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MIR142 Loss-of-Function Mutations Derepress ASH1L to Increase HOXA Gene Expression and Promote Leukemogenesis by Trissal, Maria C, Wong, Terrence N, Yao, Juo-Chin, Ramaswamy, Rahul, Kuo, Iris, Baty, Jack, Sun, Yaping, Jih, Gloria, Parikh, Nishi, Berrien-Elliott, Melissa M, Fehniger, Todd A, Ley, Timothy J, Maillard, Ivan, Reddy, Pavan R, Link, Daniel C

“…Point mutations in the seed sequence of miR-142-3p are present in a subset of acute myelogenous leukemia (AML) and in several subtypes of B-cell lymphoma…”
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A phase 2 multicenter study of lenalidomide in relapsed or refractory classical Hodgkin lymphoma by Fehniger, Todd A., Larson, Sarah, Trinkaus, Kathryn, Siegel, Marilyn J., Cashen, Amanda F., Blum, Kristie A., Fenske, Timothy S., Hurd, David D., Goy, Andre, Schneider, Stephanie E., Keppel, Catherine R., Wagner-Johnston, Nina D., Carson, Kenneth R., Bartlett, Nancy L.

“…Relapsed or refractory (rel/ref) classical Hodgkin lymphoma (cHL) remains a clinical challenge, with limited effective treatment options available after stem…”
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Acquisition of Murine NK Cell Cytotoxicity Requires the Translation of a Pre-existing Pool of Granzyme B and Perforin mRNAs by Fehniger, Todd A., Cai, Sheng F., Cao, Xuefang, Bredemeyer, Andrew J., Presti, Rachel M., French, Anthony R., Ley, Timothy J.

“…Although activated murine NK cells can use the granule exocytosis pathway to kill target cells immediately upon recognition, resting murine NK cells are…”
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MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells by Berrien-Elliott, Melissa M., Sun, Yaping, Neal, Carly, Ireland, Aaron, Trissal, Maria C., Sullivan, Ryan P., Wagner, Julia A., Leong, Jeffrey W., Wong, Pamela, Mah-Som, Annelise Y., Wong, Terrence N., Schappe, Timothy, Keppel, Catherine R., Cortez, Victor S., Stamatiades, Efstathios G., Li, Ming O., Colonna, Marco, Link, Daniel C., French, Anthony R., Cooper, Megan A., Wang, Wei-Le, Boldin, Mark P., Reddy, Pavan, Fehniger, Todd A.

“…Natural killer (NK) cells are cytotoxic type 1 innate lymphoid cells (ILCs) that defend against viruses and mediate anti-tumor responses, yet mechanisms…”
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Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity by Wagner, Julia A., Wong, Pamela, Schappe, Timothy, Berrien-Elliott, Melissa M., Cubitt, Celia, Jaeger, Natalia, Lee, Madeline, Keppel, Cassie R., Marin, Nancy D., Foltz, Jennifer A., Marsala, Lynne, Neal, Carly C., Sullivan, Ryan P., Schneider, Stephanie E., Keppel, Molly P., Saucier, Nermina, Cooper, Megan A., Fehniger, Todd A.

“…Natural killer (NK) cells are cytotoxic innate lymphoid cells (ILCs) that mediate antiviral and antitumor responses and require the transcriptional regulator…”
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T-BET and EOMES sustain mature human NK cell identity and antitumor function by Wong, Pamela, Foltz, Jennifer A, Chang, Lily, Neal, Carly C, Yao, Tony, Cubitt, Celia C, Tran, Jennifer, Kersting-Schadek, Samantha, Palakurty, Sathvik, Jaeger, Natalia, Russler-Germain, David A, Marin, Nancy D, Gang, Margery, Wagner, Julia A, Zhou, Alice Y, Jacobs, Miriam T, Foster, Mark, Schappe, Timothy, Marsala, Lynne, McClain, Ethan, Pence, Patrick, Becker-Hapak, Michelle, Fisk, Bryan, Petti, Allegra A, Griffith, Obi L, Griffith, Malachi, Berrien-Elliott, Melissa M, Fehniger, Todd A

“…Since the T-box transcription factors (TFs) T-BET and EOMES are necessary for initiation of NK cell development, their ongoing requirement for mature NK cell…”
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CD56 regulates human NK cell cytotoxicity through Pyk2 by Gunesch, Justin T, Dixon, Amera L, Ebrahim, Tasneem Am, Berrien-Elliott, Melissa M, Tatineni, Swetha, Kumar, Tejas, Hegewisch-Solloa, Everardo, Fehniger, Todd A, Mace, Emily M

“…Human natural killer (NK) cells are defined as CD56 CD3 . Despite its ubiquitous expression on human NK cells the role of CD56 (NCAM) in human NK cell…”
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The biology of human natural killer-cell subsets by Cooper, Megan A, Fehniger, Todd A, Caligiuri, Michael A

“…Human natural killer (NK) cells comprise ≈15% of all circulating lymphocytes. Owing to their early production of cytokines and chemokines, and ability to lyse…”
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Human Cytokine-Induced Memory-Like Natural Killer Cells by Berrien-Elliott, Melissa M., Wagner, Julia A., Fehniger, Todd A.

“…Natural killer (NK) cells are innate lymphoid cells that are important for host defense against infection and mediate antitumor responses. Recent reports from…”
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A phase II study of interrupted and continuous dose lenalidomide in relapsed/refractory Hodgkin lymphoma by Fehniger, Todd A, Watkins, Marcus P, Ezenwajiaku, Nkiruka, Wan, Fei, Hurd, David D, Cashen, Amanda F, Blum, Kristie A, Goy, Andre, Fenske, Timothy S, Wagner-Johnston, Nina D, Carson, Kenneth, Siegel, Marilyn J, Russler-Germain, David, Schneider, Stephanie E, Mehta-Shah, Neha, Kahl, Brad, Bartlett, Nancy L

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