Search Results - "Fehlings, Michael G."

Time is spine: a review of translational advances in spinal cord injury by Badhiwala, Jetan H, Ahuja, Christopher S, Fehlings, Michael G

“…Acute traumatic spinal cord injury (SCI) is a devastating event with far-reaching physical, emotional, and economic consequences for patients, families, and…”
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Regeneration of Spinal Cord Connectivity Through Stem Cell Transplantation and Biomaterial Scaffolds by Katoh, Hiroyuki, Yokota, Kazuya, Fehlings, Michael G

“…Significant progress has been made in the treatment of spinal cord injury (SCI). Advances in post-trauma management and intensive rehabilitation have…”
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The Role of Microglia in Modulating Neuroinflammation after Spinal Cord Injury by Brockie, Sydney, Hong, James, Fehlings, Michael G.

“…The pathobiology of traumatic and nontraumatic spinal cord injury (SCI), including degenerative myelopathy, is influenced by neuroinflammation. The…”
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MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers by Freund, Patrick, Seif, Maryam, Weiskopf, Nikolaus, Friston, Karl, Fehlings, Michael G, Thompson, Alan J, Curt, Armin

“…Traumatic spinal cord injury occurs when an external physical impact damages the spinal cord and leads to permanent neurological dysfunction and disability,…”
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Traumatic Spinal Cord Injury—Repair and Regeneration by Ahuja, Christopher S., Nori, Satoshi, Tetreault, Lindsay, Wilson, Jefferson, Kwon, Brian, Harrop, James, Choi, David, Fehlings, Michael G.

“…Abstract BACKGROUND: Traumatic spinal cord injuries (SCI) have devastating consequences for the physical, financial, and psychosocial well-being of patients…”
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The influence of timing of surgical decompression for acute spinal cord injury: a pooled analysis of individual patient data by Badhiwala, Jetan H, Wilson, Jefferson R, Witiw, Christopher D, Harrop, James S, Vaccaro, Alexander R, Aarabi, Bizhan, Grossman, Robert G, Geisler, Fred H, Fehlings, Michael G

“…Although there is a strong biological rationale for early decompression of the injured spinal cord, the influence of the timing of surgical decompression for…”
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Pathobiology of cervical spondylotic myelopathy by Karadimas, Spyridon K., Gatzounis, Georgios, Fehlings, Michael G.

“…In this narrative review, we aim to outline what is currently known about the pathophysiology of cervical spondylotic myelopathy (CSM), the most common cause…”
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Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS) by Fehlings, Michael G, Vaccaro, Alexander, Wilson, Jefferson R, Singh, Anoushka, W Cadotte, David, Harrop, James S, Aarabi, Bizhan, Shaffrey, Christopher, Dvorak, Marcel, Fisher, Charles, Arnold, Paul, Massicotte, Eric M, Lewis, Stephen, Rampersaud, Raja

“…There is convincing preclinical evidence that early decompression in the setting of spinal cord injury (SCI) improves neurologic outcomes. However, the effect…”
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Using a machine learning approach to predict outcome after surgery for degenerative cervical myelopathy by Merali, Zamir G, Witiw, Christopher D, Badhiwala, Jetan H, Wilson, Jefferson R, Fehlings, Michael G

“…Degenerative cervical myelopathy (DCM) is a spinal cord condition that results in progressive non-traumatic compression of the cervical spinal cord. Spine…”
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Magnetic resonance imaging assessment of degenerative cervical myelopathy: a review of structural changes and measurement techniques by Nouri, Aria, Martin, Allan R, Mikulis, David, Fehlings, Michael G

“…Degenerative cervical myelopathy encompasses a spectrum of age-related structural changes of the cervical spine that result in static and dynamic injury to the…”
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Neural stem cell mediated recovery is enhanced by Chondroitinase ABC pretreatment in chronic cervical spinal cord injury by Suzuki, Hidenori, Ahuja, Christopher S, Salewski, Ryan P, Li, Lijun, Satkunendrarajah, Kajana, Nagoshi, Narihito, Shibata, Shinsuke, Fehlings, Michael G

“…Traumatic spinal cord injuries (SCIs) affect millions of people worldwide; the majority of whom are in the chronic phase of their injury. Unfortunately, most…”
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Use of Machine Learning and Artificial Intelligence to Drive Personalized Medicine Approaches for Spine Care by Khan, Omar, Badhiwala, Jetan H., Grasso, Giovanni, Fehlings, Michael G.

“…Personalized medicine is a new paradigm of healthcare in which interventions are based on individual patient characteristics rather than on “one-size-fits-all”…”
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Translating mechanisms of neuroprotection, regeneration, and repair to treatment of spinal cord injury by Siddiqui, Ahad M, Khazaei, Mohamad, Fehlings, Michael G

“…One of the big challenges in neuroscience that remains to be understood is why the central nervous system is not able to regenerate to the extent that the…”
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Chondroitinase and growth factors enhance activation and oligodendrocyte differentiation of endogenous neural precursor cells after spinal cord injury by Karimi-Abdolrezaee, Soheila, Schut, Desiree, Wang, Jian, Fehlings, Michael G

“…The adult spinal cord harbours a population of multipotent neural precursor cells (NPCs) with the ability to replace oligodendrocytes. However, despite this…”
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Synergistic Effects of Transplanted Adult Neural Stem/Progenitor Cells, Chondroitinase, and Growth Factors Promote Functional Repair and Plasticity of the Chronically Injured Spinal Cord by Karimi-Abdolrezaee, Soheila, Eftekharpour, Eftekhar, Wang, Jian, Schut, Desiree, Fehlings, Michael G

“…The transplantation of neural stem/progenitor cells (NPCs) is a promising therapeutic strategy for spinal cord injury (SCI). However, to date NPC…”
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Characterization of vascular disruption and blood-spinal cord barrier permeability following traumatic spinal cord injury by Figley, Sarah A, Khosravi, Ramak, Legasto, Jean M, Tseng, Yun-Fan, Fehlings, Michael G

“…Significant vascular changes occur subsequent to spinal cord injury (SCI), which contribute to progressive pathophysiology. In the present study, we used…”
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Pathophysiology and Natural History of Cervical Spondylotic Myelopathy by Karadimas, Spyridon K, Erwin, W Mark, Ely, Claire G, Dettori, Joseph R, Fehlings, Michael G

“…STUDY DESIGN.This study is a combination of narrative and systematic review. OBJECTIVE.Clinicians who deal with cervical spondylotic myelopathy (CSM) should be…”
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Vertebral compression fracture after stereotactic body radiotherapy for spinal metastases by Sahgal, Arjun, Dr, Whyne, Cari M, Prof, Ma, Lijun, Prof, Larson, David A, Prof, Fehlings, Michael G, Prof

“…Summary The use of stereotactic body radiotherapy for metastatic spinal tumours is increasing. Serious adverse events for this treatment include vertebral…”
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Clinical trials for neuroregenerative therapies for spinal cord injury: what have we learnt so far? by Wong, Raymond, Hejrati, Nader, Fehlings, Michael G

“…There remains a lack of effective regenerative therapies to treat traumatic spinal cord injury (SCI). On a global level, patients living with SCI, their…”
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Emerging therapies for acute traumatic spinal cord injury by Wilson, Jefferson R, Forgione, Nicole, Fehlings, Michael G

“…There are currently about 85 000 Canadians living with spinal cord injuries, more than half of which are secondary to trauma.1 As the population ages, the…”
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