Search Results - "Feelders, R A"

The burden of Cushing's disease: clinical and health-related quality of life aspects by FEELDERS, R. A, PULGAR, S. J, KEMPEL, A, PEREIRA, A. M

“…Cushing's disease (CD) is a rare endocrine disorder characterized by excess secretion of ACTH due to a pituitary adenoma. Current treatment options are limited…”
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Hypercoagulability in Cushing's syndrome: prevalence, pathogenesis and treatment by van der Pas, R., Leebeek, F.W.G., Hofland, L.J., de Herder, W.W., Feelders, R.A.

“…Summary Cushing's syndrome is not only accompanied by an increased prevalence of cardiovascular disease but also by a hypercoagulable state that is reflected…”
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Risk Factors for Hemodynamic Instability during Surgery for Pheochromocytoma by Bruynzeel, H, Feelders, R. A, Groenland, T. H. N, van den Meiracker, A. H, van Eijck, C. H. J, Lange, J. F, de Herder, W. W, Kazemier, G

“…Background: Surgery on pheochromocytoma carries a risk for hemodynamic (HD) instability. The aim of this study was to identify preoperative risk factors for…”
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Mitotane levels predict the outcome of patients with adrenocortical carcinoma treated adjuvantly following radical resection by Terzolo, M, Baudin, A E, Ardito, A, Kroiss, M, Leboulleux, S, Daffara, F, Perotti, P, Feelders, R A, deVries, J H, Zaggia, B, De Francia, S, Volante, M, Haak, H R, Allolio, B, Al Ghuzlan, A, Fassnacht, M, Berruti, A

“…ContextMitotane plasma concentrations ≥14 mg/l have been shown to predict tumor response and better survival in patients with advanced adrenocortical carcinoma…”
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Future directions in the diagnosis and medical treatment of adrenocortical carcinoma by Creemers, S G, Hofland, L J, Korpershoek, E, Franssen, G J H, van Kemenade, F J, de Herder, W W, Feelders, R A

“…Adrenocortical carcinoma (ACC) is a rare disease with a poor prognosis. Discrimination between ACCs and adrenocortical adenomas (ACAs) remains challenging,…”
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Differentiating between Cushing's disease and pseudo-Cushing's syndrome: comparison of four tests by Alwani, R A, Schmit Jongbloed, L W, de Jong, F H, van der Lely, A J, de Herder, W W, Feelders, R A

“…ObjectiveTo evaluate the diagnostic performance of four different tests in order to differentiate between Cushing's disease (CD) and pseudo-Cushing's syndrome…”
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Incidence of Venous Thromboembolism in Patients with Cushing's Syndrome: A Multicenter Cohort Study by Stuijver, D. J. F, van Zaane, B, Feelders, R. A, Debeij, J, Cannegieter, S. C, Hermus, A. R, van den Berg, G, Pereira, A. M, de Herder, W. W, Wagenmakers, M. A. E. M, Kerstens, M. N, Zelissen, P. M. J, Fliers, E, Schaper, N, Drent, M. L, Dekkers, O. M, Gerdes, V. E. A

“…Context: Venous thrombosis has frequently been reported in patients with endogenous Cushing's syndrome (CS). Objective: The aim of this study was to evaluate…”
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Long-Term Efficacy and Safety of Pegvisomant in Combination With Long-Acting Somatostatin Analogs in Acromegaly by Neggers, S. J. C. M. M, Franck, S. E, de Rooij, F. W. M, Dallenga, A. H. G, Poublon, R. M. L, Feelders, R. A, Janssen, J. A. M. J. L, Buchfelder, M, Hofland, L. J, Jørgensen, J. O. L, van der Lely, A. J

“…Background: Treatment for acromegaly patients with long-acting somatotropin release-inhibiting factor (LA-SRIF) often does not result in complete normalization…”
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A Novel Tool in the Diagnosis and Follow-Up of (Cyclic) Cushing's Syndrome: Measurement of Long-Term Cortisol in Scalp Hair by Manenschijn, L, Koper, J. W, van den Akker, E. L. T, de Heide, L. J. M, Geerdink, E. A. M, de Jong, F. H, Feelders, R. A, van Rossum, E. F. C

“…Background: Measurement of cortisol in 24-h urine collections and midnight saliva are standard screening tests for Cushing's syndrome (CS). These tests reflect…”
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Current clinical practice for thromboprophylaxis management in patients with Cushing's syndrome across reference centers of the European Reference Network on Rare Endocrine Conditions (Endo-ERN) by van Haalen, F M, Kaya, M, Pelsma, I C M, Dekkers, O M, Biermasz, N R, Cannegieter, S C, Huisman, M V, van Vlijmen, B J M, Feelders, R A, Klok, F A, Pereira, A M

“…Cushing's syndrome (CS) is associated with an hypercoagulable state and an increased risk of venous thromboembolism (VTE). Evidence-based guidelines on…”
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Fluconazole inhibits human adrenocortical steroidogenesis in vitro by van der Pas, R, Hofland, L J, Hofland, J, Taylor, A E, Arlt, W, Steenbergen, J, van Koetsveld, P M, de Herder, W W, de Jong, F H, Feelders, R A

“…The antifungal agent ketoconazole is often used to suppress cortisol production in patients with Cushing's syndrome (CS). However, ketoconazole has serious…”
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Combined treatment for acromegaly with long-acting somatostatin analogs and pegvisomant: long-term safety for up to 4.5 years (median 2.2 years) of follow-up in 86 patients by Neggers, SJCMM, de Herder, WW, Janssen, JAMJL, Feelders, RA, van der Lely, AJ

“…BackgroundWe previously reported on the efficacy, safety, and quality of life (QoL) of long-acting somatostatin analogs (SSA) and (twice) weekly pegvisomant…”
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Improved Control of Severe Hypoglycemia in Patients with Malignant Insulinomas by Peptide Receptor Radionuclide Therapy by van Schaik, E, van Vliet, E. I, Feelders, R. A, Krenning, E. P, Khan, S, Kamp, K, Valkema, R, van Nederveen, F. H, Teunissen, J. J. M, Kwekkeboom, D. J, de Herder, W. W

“…Context: Insulinomas are relatively rare neuroendocrine tumors of the pancreas. Only 10% are considered malignant. Control of insulin hypersecretion and…”
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The Hypercoagulable State in Cushing's Disease Is Associated with Increased Levels of Procoagulant Factors and Impaired Fibrinolysis, But Is Not Reversible after Short-Term Biochemical Remission Induced by Medical Therapy by van der Pas, R, de Bruin, C, Leebeek, F. W. G, de Maat, M. P. M, Rijken, D. C, Pereira, A. M, Romijn, J. A, Netea-Maier, R. T, Hermus, A. R, Zelissen, P. M. J, de Jong, F. H, van der Lely, A. J, de Herder, W. W, Lamberts, S. W. J, Hofland, L. J, Feelders, R. A

“…Context: Cushing's disease (CD) is accompanied by an increased risk of venous thromboembolism. Surgery is the primary treatment of CD. Objective: The aim of…”
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Quality of Life in Acromegalic Patients during Long-Term Somatostatin Analog Treatment with and without Pegvisomant by Neggers, S. J. C. M. M., van Aken, M. O., de Herder, W. W., Feelders, R. A., Janssen, J. A. M. J. L., Badia, X., Webb, S. M., van der Lely, A. J.

“…Objective: The objective of the study was to assess whether weekly administration of 40 mg pegvisomant (PEG-V) improves quality of life (QoL) and metabolic…”
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Combined therapy with somatostatin analogues and weekly pegvisomant in active acromegaly by Feenstra, J, de Herder, WW, ten Have, SMTH, van den Beld, AW, Feelders, RA, Janssen, JAMJL, van der Lely, AJ

“…Pegvisomant monotherapy once daily returns concentrations of insulin-like growth factor I (IGF-I) to normal in most patients with acromegaly, but is very…”
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Preoperative Normalization of Cortisol Levels in Cushing's Disease After Medical Treatment: Consequences for Somatostatin and Dopamine Receptor Subtype Expression and In Vitro Response to Somatostatin Analogs and Dopamine Agonists by van der Pas, R, Feelders, R. A, Gatto, F, de Bruin, C, Pereira, A. M, van Koetsveld, P. M, Sprij-Mooij, D. M, Waaijers, A. M, Dogan, F, Schulz, S, Kros, J. M, Lamberts, S. W. J, Hofland, L. J

“…Context: Corticotroph pituitary adenomas often highly express the dopamine 2 receptor (D2R) and somatostatin receptor subtype 5 (sst5). The sst2 expression is…”
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Inhibition of Human Adrenocortical Cancer Cell Growth by Temozolomide in Vitro and the Role of the MGMT Gene by Creemers, S. G, van Koetsveld, P. M, van den Dungen, E. S. R, Korpershoek, E, van Kemenade, F. J, Franssen, G. J. H, de Herder, W. W, Feelders, R. A, Hofland, L. J

“…Context: Treatment of patients with adrenocortical carcinomas (ACC) with mitotane and/or chemotherapy is often associated with toxicity and poor tumor…”
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Mifepristone Effects on Tumor Somatostatin Receptor Expression in Two Patients with Cushing's Syndrome due to Ectopic Adrenocorticotropin Secretion by de Bruin, C, Hofland, L. J, Nieman, L. K, van Koetsveld, P. M, Waaijers, A. M, Sprij-Mooij, D. M, van Essen, M, Lamberts, S. W. J, de Herder, W. W, Feelders, R. A

“…Context: Two patients presented with Cushing's syndrome due to ectopic ACTH secretion. Initial localization studies included computed tomography, magnetic…”
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Treatment of patients with gastro-entero-pancreatic (GEP) tumours with the novel radiolabelled somatostatin analogue [177Lu-DOTA0, Tyr3]octreotate by KWEKKEBOOM, D. J, BAKKER, W. H, ERION, J. L, KRENNING, E. P, KAM, B. L, TEUNISSEN, J. J. M, KOOIJ, P. P. M, HERDER, W. W, FEELDERS, R. A, EIJCK, C. H. J, JONG, M, SRINIVASAN, A

“…Medical treatment and chemotherapy are seldom successful in achieving objective tumour reduction in patients with metastatic neuroendocrine tumours. Treatment…”
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