Search Results - "Fee, Brian E."

IRGM1 supports host defense against intracellular bacteria through suppression of type I interferon in mice by Rai, Prashant, Sharpe, Martin, Ganta, Charan K, Baker, Paul J, Mayer-Barber, Katrin D, Fee, Brian E, Taylor, Gregory A, Fessler, Michael B

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Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor by Wang, Yu, Chandra, Rashmi, Samsa, Leigh Ann, Gooch, Barry, Fee, Brian E, Cook, J Michael, Vigna, Steven R, Grant, Augustus O, Liddle, Rodger A

“…Cholecystokinin (CCK) is produced by discrete endocrine cells in the proximal small intestine and is released following the ingestion of food. CCK is the…”
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Irgm1 regulates metabolism and function in T cell subsets by Alwarawrah, Yazan, Danzaki, Keiko, Nichols, Amanda G., Fee, Brian E., Bock, Cheryl, Kucera, Gary, Hale, Laura P., Taylor, Gregory A., MacIver, Nancie J.

“…Immunity Related GTPases (IRG) are a family of proteins produced during infection that regulate membrane remodeling events in cells, particularly autophagy and…”
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Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium by Taylor, Gregory A, Huang, Hsin-I, Fee, Brian E, Youssef, Nourhan, Jewell, Mark L, Cantillana, Viviana, Schoenborn, Alexi A, Rogala, Allison R, Buckley, Anne F, Feng, Carl G, Vallance, Bruce A, Gulati, Ajay S, Hammer, Gianna E

“…IRGM and its mouse orthologue Irgm1 are dynamin-like proteins that regulate vesicular remodeling, intracellular microbial killing, and pathogen immunity. IRGM…”
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Treatment-related biomarkers in pulmonary hypertension patients on oral therapies by Swaminathan, Aparna C., Zhu, Hongmei, Tapson, Victor, Lokhnygina, Yuliya, Poms, Abby, Kelleher, Zach, Gaspard, Elijah, Kennedy, Karla, Fee, Brian E., Fortin, Terry, Mason, S. Nicholas, Parikh, Kishan, McMahon, Tim J.

“…Abstract Background Multiple classes of oral therapy are available for the treatment of pulmonary arterial hypertension (PAH), but there is little to guide…”
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Th17 Immunity in the Colon Is Controlled by Two Novel Subsets of Colon-Specific Mononuclear Phagocytes by Huang, Hsin-I, Jewell, Mark L, Youssef, Nourhan, Huang, Min-Nung, Hauser, Elizabeth R, Fee, Brian E, Rudemiller, Nathan P, Privratsky, Jamie R, Zhang, Junyi J, Reyes, Estefany Y, Wang, Donghai, Taylor, Gregory A, Gunn, Michael D, Ko, Dennis C, Cook, Donald N, Chandramohan, Vidyalakshmi, Crowley, Steven D, Hammer, Gianna Elena

“…Intestinal immunity is coordinated by specialized mononuclear phagocyte populations, constituted by a diversity of cell subsets. Although the cell subsets…”
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Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice by Rogala, Allison R, Schoenborn, Alexi A, Fee, Brian E, Cantillana, Viviana A, Joyce, Maria J, Gharaibeh, Raad Z, Roy, Sayanty, Fodor, Anthony A, Sartor, R Balfour, Taylor, Gregory A, Gulati, Ajay S

“…Crohn's disease (CD) represents a chronic inflammatory disorder of the intestinal tract. Several susceptibility genes have been linked to CD, though their…”
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AJAP1 is Dysregulated at an Early Stage of Gliomagenesis and Suppresses Invasion Through Cytoskeleton Reorganization by Han, Lei, Zhang, Kai‐Liang, Zhang, Jun‐Xia, Zeng, Liang, Di, Chun‐Hui, Fee, Brian E., Rivas, Miriam, Bao, Zhao‐Shi, Jiang, Tao, Bigner, Darrell, Kang, Chun‐Sheng, Adamson, David Cory

“…Summary Aims Down‐regulation of AJAP1 in glioblastoma multiforme (GBM) has been reported. However, the expression profiles of AJAP1 in gliomas and the…”
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Murine Irgm Paralogs Regulate Nonredundant Functions To Execute Host Defense to Toxoplasma gondii by Dockterman, Jacob, Fee, Brian E, Taylor, Gregory A, Coers, Jörn

“…Gamma interferon (IFN-γ)-induced immunity-related GTPases (IRGs) confer cell-autonomous immunity to the intracellular protozoan pathogen Toxoplasma gondii…”
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Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype by Romac, Joelle M-J, Ohmuraya, Masaki, Bittner, Cathy, Majeed, M Faraz, Vigna, Steven R, Que, Jianwen, Fee, Brian E, Wartmann, Thomas, Yamamura, Ken-ichi, Liddle, Rodger A

“…Endogenous trypsin inhibitors are synthesized, stored, and secreted by pancreatic acinar cells. It is believed that they play a protective role in the pancreas…”
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The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion by Hjelmeland, Anita B, Lattimore, Kathryn P, Fee, Brian E, Shi, Qing, Wickman, Sarah, Keir, Stephen T, Hjelmeland, Mark D, Batt, David, Bigner, Darell D, Friedman, Henry S, Rich, Jeremy N

“…Monotherapies have proven largely ineffective for the treatment of glioblastomas, suggesting that increased patient benefit may be achieved by combining…”
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Type I interferon signaling and peroxisomal dysfunction contribute to enhanced inflammatory cytokine production in IRGM1-deficient macrophages by Fee, Brian E., Fee, Lanette R., Menechella, Mark, Affeldt, Bethann, Sprouse, Aemilia R., Bounini, Amina, Alwarawrah, Yazan, Molloy, Caitlyn T., Ilkayeva, Olga R., Prinz, Joseph A., Lenz, Devi Swain, MacIver, Nancie J., Rai, Prashant, Fessler, Michael B., Coers, Jörn, Taylor, Gregory A.

“…The human IRGM gene has been linked to inflammatory diseases including sepsis and Crohn’s disease. Decreased expression of human IRGM, or the mouse orthologues…”
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Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages by Schmidt, Elyse A., Fee, Brian E., Henry, Stanley C., Nichols, Amanda G., Shinohara, Mari L., Rathmell, Jeffrey C., MacIver, Nancie J., Coers, Jörn, Ilkayeva, Olga R., Koves, Timothy R., Taylor, Gregory A.

“…The immunity-related GTPases (IRGs) are a family of proteins that are induced by interferon (IFN)-γ and play pivotal roles in immune and inflammatory…”
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Misexpression of the Eyes Absent Family Triggers the Apoptotic Program by Clark, S. Wesley, Fee, Brian E., Cleveland, John L.

“…Genetic studies in Drosophila and mice have shown that eyes absent (eya) is an important and conserved transcriptional regulator of development. Along with…”
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Adherens junctional associated protein-1: A novel 1p36 tumor suppressor candidate in gliomas by ZENG, LIANG, FEE, BRIAN E, RIVAS, MIRIAM V, LIN, JAMES, ADAMSON, DAVID CORY

“…In a broad range of human cancers 1p36 has been a mutational hotspot which strongly suggests that the loss of tumor suppressor activity maps to this genomic…”
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The adherens junction-associated protein 1 is a negative transcriptional regulator of MAGEA2, which potentiates temozolomide-induced apoptosis in GBM by ZENG, LIANG, KANG, CHUNSHENG, DI, CHUNHUI, FEE, BRIAN E, RIVAS, MIRIAM, LIN, JAMES, ADAMSON, DAVID CORY

“…Previous studies identified the frequent loss of adherens junction-associated protein 1 (AJAP1) expression in glioblastoma (GBM) and its correlation with worse…”
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Endogenous elevation of plasma cholecystokinin does not prevent gallstones by Shahid, Rafiq A., Wang, David Q.-H., Fee, Brian E., McCall, Shannon J., Romac, Joelle M.-J., Vigna, Steven R., Liddle, Rodger A.

“…Background Regular gall bladder contraction reduces bile stasis and prevents gallstone formation. Intraduodenal administration of exogenous pancreatic…”
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Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1 by EISCHEN, Christine M, PACKHAM, Graham, NIP, John, FEE, Brian E, HIEBERT, Scott W, ZAMBETTI, Gerard P, CLEVELAND, John L

“…Malignant transformation occurs in cells that overexpress c-Myc or that inappropriately activate E2F-1. Transformation occurs after the selection of cells that…”
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Initiation Site Binding Protein and the Initiator-Like Promoter Element of Mouse Mammary Tumor Virus by Fee, Brian E., Steinke, John W., Pierce, Jennifer, Peterson, David O.

“…The mouse mammary tumor virus (MMTV) promoter contains an element near its transcription initiation site that is recognized by a protein termed initiation site…”
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A novel Eyes Absent 2 protein is expressed in the human eye by Fee, Brian E., Doyle, Christina A., Cleveland, John L.

“…The Drosophila eyes absent ( eya) gene has a role in regulating cell death and/or differentiation and is expressed throughout development. We evaluated the…”
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