Search Results - "Fedyk, Eric R."

Safety, tolerability, pharmacokinetics and pharmacodynamics of the anti‐CD38 cytolytic antibody TAK‐079 in healthy subjects by Fedyk, Eric R., Zhao, Lin, Koch, Annelize, Smithson, Glennda, Estevam, Jose, Chen, Grace, Lahu, Gezim, Roepcke, Stefan, Lin, Jianchang, Mclean, Lachy

“…Aims This investigation characterised tolerability, pharmacokinetics and pharmacodynamics of the anti‐CD38 antibody TAK‐079. Methods A randomised,…”
Get full text

A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Single‐Dose and Multiple‐Rising‐Dose Study of the BTK Inhibitor TAK‐020 in Healthy Subjects by Esfandiari, Ehsanollah, Chen, Mary, Smithson, Glennda, Blair, Derek, Faessel, Helene, Wagner, John, Mclean, Lachy, Fedyk, Eric R.

“…Bruton’s tyrosine kinase (BTK) is a target for treatment of hematologic malignancies and autoimmune diseases. TAK‐020 is a highly selective covalent BTK…”
Get full text

A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys by Korver, Wouter, Carsillo, Mary, Yuan, Josh, Idamakanti, Neeraja, Wagoner, Matthew, Shi, Pu, Xia, Cindy Q, Smithson, Glennda, McLean, Lachy, Zalevsky, Jonathan, Fedyk, Eric R

“…Ectoenzyme CD38 is increased on lymphocytes in response to an antigenic challenge and it is hypothesized that targeting these activated lymphocytes could…”
Get more information

Expression of Stromal-Derived Factor-1 Is Decreased by IL-1 and TNF and in Dermal Wound Healing by Fedyk, Eric R, Jones, Dan, Critchley, Hilary O. D, Phipps, Richard P, Blieden, Timothy M, Springer, Timothy A

“…Stromal-derived factor-1 (SDF-1) is a CXC chemokine that is believed to be constitutively expressed by stromal cells of numerous tissues. In this report, we…”
Get full text

Antagonizing the α4β1 integrin, but not α4β7, inhibits leukocytic infiltration of the central nervous system in rhesus monkey experimental autoimmune encephalomyelitis by Haanstra, Krista G, Hofman, Sam O, Lopes Estêvão, Dave M, Blezer, Erwin L A, Bauer, Jan, Yang, Li-Li, Wyant, Tim, Csizmadia, Vilmos, 't Hart, Bert A, Fedyk, Eric R

“…The immune system is characterized by the preferential migration of lymphocytes through specific tissues (i.e., tissue tropism). Tissue tropism is mediated, in…”
Get full text

Pharmacokinetics and pharmacodynamics of the cytolytic anti‐CD38 human monoclonal antibody TAK‐079 in monkey – model assisted preparation for the first in human trial by Roepcke, Stefan, Plock, Nele, Yuan, Josh, Fedyk, Eric R., Lahu, Gezim, Zhao, Lin, Smithson, Glennda

“…We are studying the fully human, IgG1λ cytolytic monoclonal antibody TAK‐079, which binds CD38. CD38 is expressed on plasma and natural killer (NK) cells…”
Get full text

Maturation decreases responsiveness of human bone marrow B lineage cells to stromal-derived factor 1 (SDF-1) by Fedyk, Eric R., Ryan, Daniel H., Ritterman, Ion, Springer, Timothy A.

“…We compared the chemotactic responsiveness of different subsets of human B lineage cells to stromal derived factor‐1 (SDF‐1). High percentages (30–40% of…”
Get full text

Pharmacokinetics and pharmacodynamics of the cytolytic anti‐ CD 38 human monoclonal antibody TAK ‐079 in monkey – model assisted preparation for the first in human trial by Roepcke, Stefan, Plock, Nele, Yuan, Josh, Fedyk, Eric R., Lahu, Gezim, Zhao, Lin, Smithson, Glennda

“…Abstract We are studying the fully human, IgG1λ cytolytic monoclonal antibody TAK ‐079, which binds CD 38. CD 38 is expressed on plasma and natural killer ( NK…”
Get full text

Effect of an experimental proteasome inhibitor on the cytoskeleton, cytosolic protein turnover, and induction in the neuronal cells in vitro by Csizmadia, Vilmos, Raczynski, Arek, Csizmadia, Eva, Fedyk, Eric R., Rottman, James, Alden, Carl L.

“…GT-1 murine neuronal cells exposed to an experimental proteasome inhibitor (EPI) for 24 h showed increased cell death via a non-apoptotic mechanism, as…”
Get full text

Role of Regulator of G Protein Signaling 16 in Inflammation- Induced T Lymphocyte Migration and Activation by Lippert, Eric, Yowe, David L, Gonzalo, Jose-Angel, Justice, J. Paul, Webster, Jeremy M, Fedyk, Eric R, Hodge, Martin, Miller, Cheryl, Gutierrez-Ramos, Jose-Carlos, Borrego, Francisco, Keane-Myers, Andrea, Druey, Kirk M

“…Chemokine-induced T lymphocyte recruitment to the lung is critical for allergic inflammation, but chemokine signaling pathways are incompletely understood…”
Get full text

Correlation of serpin–protease expression by comparative analysis of real-time PCR profiling data by Badola, Sunita, Spurling, Heidi, Robison, Keith, Fedyk, Eric R., Silverman, Gary A., Strayle, Jochen, Kapeller, Rosana, Tsu, Christopher A.

“…Imbalanced protease activity has long been recognized in the progression of disease states such as cancer and inflammation. Serpins, the largest family of…”
Get full text

Exclusive antagonism of the α4β7 integrin by vedolizumab confirms the gut‐selectivity of this pathway in primates by Fedyk, Eric R., Wyant, Tim, Yang, Li‐Li, Csizmadia, Vilmos, Burke, Kristine, Yang, Hua, Kadambi, Vivek J.

“…Background: Biological therapies that antagonize specific molecules have demonstrated efficacy in inflammatory bowel diseases, but infections resulting from…”
Get full text

Pharmacological characterization of guinea pig chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) by Liu, Fang, Gonzalo, Jose Angel, Manning, Stephen, O’Connell, Laura E., Fedyk, Eric R., Burke, Kristine E., Elder, Amy M., Pulido, Jacqueline C., Cao, Wei, Tayber, Olga, Qiu, Yubin, Ghosh, Shomir, Ocain, Timothy D., Hodge, Martin R., Suzuki-Yagawa, Yuriko

“…Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), a G protein-coupled receptor activated by prostaglandin D 2 (PGD 2), has been…”
Get full text

IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2 by Smith, R S, Fedyk, E R, Springer, T A, Mukaida, N, Iglewski, B H, Phipps, R P

“…The destructive pulmonary inflammation associated with Pseudomonas aeruginosa colonization is caused, in part, by the production of the chemokine IL-8, which…”
Get full text

Exclusive antagonism of the [alpha]4[beta]7 integrin by vedolizumab confirms the gut-selectivity of this pathway in primates by Fedyk, Eric R, Wyant, Tim, Yang, Li-Li, Csizmadia, Vilmos, Burke, Kristine, Yang, Hua, Kadambi, Vivek J

“…Background: Biological therapies that antagonize specific molecules have demonstrated efficacy in inflammatory bowel diseases, but infections resulting from…”
Get full text

Antagonizing the alpha 4 beta 1 Integrin, but Not alpha 4 beta 7, Inhibits Leukocytic Infiltration of the Central Nervous System in Rhesus Monkey Experimental Autoimmune Encephalomyelitis by Haanstra, Krista G, Hofman, Sam O, Lopes Estevao, Dave M, Blezer, Erwin LA, Bauer, Jan, Yang, Li-Li, Wyant, Tim, Csizmadia, Vilmos, 't Hart, Bert A, Fedyk, Eric R

“…The immune system is characterized by the preferential migration of lymphocytes through specific tissues (i.e., tissue tropism). Tissue tropism is mediated, in…”
Get full text

Prostaglandin E$_{2}$ Receptors of the EP$_{2}$ and EP$_{4}$ Subtypes Regulate Activation and Differentiation of Mouse B Lymphocytes to IgE-Secreting Cells by Fedyk, Eric R., Phipps, Richard P.

“…Prostaglandin E$_{2}$ (PGE$_{2}$) is a potent lipid molecule with complex proinflammatory and immunoregulatory properties. PGE$_{2}$ can shape the immune…”
Get full text

Prostaglandin E2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells by Fedyk, E R, Phipps, R P

“…Prostaglandin E2 (PGE2) is a potent lipid molecule with complex proinflammatory and immunoregulatory properties. PGE2 can shape the immune response by…”
Get full text

Exclusive antagonism of the α4 β7 integrin by vedolizumab confirms the gut-selectivity of this pathway in primates by Fedyk, Eric R, Wyant, Tim, Yang, Li-Li, Csizmadia, Vilmos, Burke, Kristine, Yang, Hua, Kadambi, Vivek J

“…Biological therapies that antagonize specific molecules have demonstrated efficacy in inflammatory bowel diseases, but infections resulting from systemic…”
Get full text

Regulation of IgE and Cytokine Production by cAMP: Implications for Extrinsic Asthma by Fedyk, Eric R., Adawi, Adnan, Looney, R.John, Phipps, Richard P.

“…Recent investigations indicate that pharmacologic agents which elevate intracellular levels of cyclic AMP (cAMP) also enhance immunoglobulin E (IgE)…”
Get full text