Physical aspects and possibilities of laser drug delivery

Physical aspects and possibilities of laser drug delivery

The features of active laser delivery of modern chlorin-containing photosensitizing drugs under the nail plate and skin are discussed. The delivery was carried out by simultaneous microperforation of the nail plate and stimulation of laser-induced hydrodynamic processes in the drug applied to the na...

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Bibliographic Details
Published in:2022 International Conference Laser Optics (ICLO) p. 1
Main Authors: Belikov, A.V., Fedorova, Y.V., Smirnov, S.N., Kozlova, A.D.
Format: Conference Proceeding
Language:English
Published: IEEE 20-06-2022
Subjects:
drug delivery
Drugs
laser microperforation
Laser modes
Laser theory
laser-induced hydrodynamics
nail plate
Nails
Optics
Surface emitting lasers
Surface waves
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Summary:The features of active laser delivery of modern chlorin-containing photosensitizing drugs under the nail plate and skin are discussed. The delivery was carried out by simultaneous microperforation of the nail plate and stimulation of laser-induced hydrodynamic processes in the drug applied to the nail surface. The optimal parameters for microporation and active laser delivery of drugs were determined. The results of studying the absorption spectra of modern chlorin-containing photosensitizing drug "Chloderm" in the range of 400÷900 nm before and after exposure to radiation with a wavelength of 450 nm, 654 ± 10 nm and 2810 nm are presented.
ISBN:1665466634
9781665466639
ISSN:2642-5580
DOI:10.1109/ICLO54117.2022.9840186