Search Results - "Fediuk, Daryl J."

Population pharmacokinetics and exposure–response analyses of varenicline in adolescent smokers by Fediuk, Daryl J., Sweeney, Kevin, Sahasrabudhe, Vaishali, McRae, Thomas, Byon, Wonkyung

“…Varenicline is an approved smoking cessation aid in adults. Population pharmacokinetics (popPK) and exposure–response (ER) (continuous abstinence rates [CAR]…”
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End‐to‐end application of model‐informed drug development for ertugliflozin, a novel sodium‐glucose cotransporter 2 inhibitor by Fediuk, Daryl J., Nucci, Gianluca, Dawra, Vikas K., Callegari, Ernesto, Zhou, Susan, Musante, Cynthia J., Liang, Yali, Sweeney, Kevin, Sahasrabudhe, Vaishali

“…Model‐informed drug development (MIDD) is critical in all stages of the drug‐development process and almost all regulatory submissions for new agents…”
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Overview of the Clinical Pharmacology of Ertugliflozin, a Novel Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor by Fediuk, Daryl J., Nucci, Gianluca, Dawra, Vikas Kumar, Cutler, David L., Amin, Neeta B., Terra, Steven G., Boyd, Rebecca A., Krishna, Rajesh, Sahasrabudhe, Vaishali

“…Ertugliflozin, a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), is approved in the US, EU, and other regions for the treatment of adults with…”
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Metabolic Disposition of the Insect Repellent DEET and the Sunscreen Oxybenzone Following Intravenous and Skin Administration in Rats by Fediuk, Daryl J., Wang, Tao, Chen, Yufei, Parkinson, Fiona E., Namaka, Michael P., Simons, Keith J., Burczynski, Frank J., Gu, Xiaochen

“…Insect repellent N,N-diethyl-m-toluamide (DEET) and sunscreen oxybenzone have shown a synergistic percutaneous enhancement when applied concurrently. Both…”
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Meta‐Analysis of Noncompartmental Pharmacokinetic Parameters of Ertugliflozin to Evaluate Dose Proportionality and UGT1A9 Polymorphism Effect on Exposure by Marshall, Jean‐Claude, Liang, Yali, Sahasrabudhe, Vaishali, Tensfeldt, Thomas, Fediuk, Daryl J., Zhou, Susan, Krishna, Rajesh, Dawra, Vikas Kumar, Wood, Linda S., Sweeney, Kevin

“…Ertugliflozin, a sodium‐glucose cotransporter 2 inhibitor, is primarily metabolized via glucuronidation by the uridine 5′‐diphospho‐glucuronosyltransferase…”
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Effect of Renal Impairment on the Pharmacokinetics of a Single Oral Dose of Danuglipron in Participants With Type 2 Diabetes by Fediuk, Daryl J., Gorman, Donal N., Stoddard, Stephanie‐An, Zhang, Yizhong, Ogden, Adam G., Winton, Jennifer A., Saxena, Aditi R.

“…Danuglipron (PF‐06882961) is an oral, small‐molecule glucagon‐like peptide‐1 receptor agonist in development for the treatment of type 2 diabetes (T2D) and…”
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Population Pharmacokinetic Model for Ertugliflozin in Healthy Subjects and Patients With Type 2 Diabetes Mellitus by Fediuk, Daryl J., Zhou, Susan, Dawra, Vikas Kumar, Sahasrabudhe, Vaishali, Sweeney, Kevin

“…Ertugliflozin is a selective sodium‐glucose cotransporter 2 inhibitor approved as an adjunct to diet and exercise to improve glycemic control in adults with…”
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Pharmacokinetics and Pharmacodynamics of Ertugliflozin in Healthy Japanese and Western Subjects by Li, Yinhua, Nucci, Gianluca, Yamamoto, Yuichi, Fediuk, Daryl J., Sahasrabudhe, Vaishali

“…Ertugliflozin, a sodium‐glucose cotransporter 2 inhibitor, is approved for treatment of type 2 diabetes. This randomized, double‐blind (sponsor‐open) study in…”
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Population Pharmacokinetic Analyses of Ertugliflozin in Select Ethnic Populations by Fediuk, Daryl J., Sahasrabudhe, Vaishali, Dawra, Vikas Kumar, Zhou, Susan, Sweeney, Kevin

“…Ertugliflozin, a sodium‐glucose cotransporter 2 inhibitor, is approved for treatment of type 2 diabetes. Two population pharmacokinetic (PK) analyses were…”
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Effect of Food on the Pharmacokinetics of Ertugliflozin and Its Fixed‐Dose Combinations Ertugliflozin/Sitagliptin and Ertugliflozin/Metformin by Sahasrabudhe, Vaishali, Fediuk, Daryl J., Matschke, Kyle, Shi, Haihong, Liang, Yali, Hickman, Anne, Bass, Almasa, Terra, Steven G., Zhou, Susan, Krishna, Rajesh, Dawra, Vikas K.

“…Ertugliflozin, an inhibitor of sodium‐glucose cotransporter 2, is approved in the United States and European Union for the treatment of type 2 diabetes in…”
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Bioequivalence of Ertugliflozin/Sitagliptin Fixed‐Dose Combination Tablets and Coadministration of Respective Strengths of Individual Components by Fediuk, Daryl J., Matschke, Kyle, Liang, Yali, Pelletier, Kathleen B., Wei, Hua, Shi, Haihong, Bass, Almasa, Hickman, Anne, Terra, Steven G., Zhou, Susan, Krishna, Rajesh, Sahasrabudhe, Vaishali

“…A fixed‐dose combination (FDC) tablet of ertugliflozin, a selective inhibitor of sodium‐glucose cotransporter 2, and sitagliptin, a dipeptidyl peptidase‐4…”
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Tissue Deposition of the Insect Repellent DEET and the Sunscreen Oxybenzone From Repeated Topical Skin Applications in Rats by Fediuk, Daryl J., Wang, Tao, Raizman, Joshua E., Parkinson, Fiona E., Gu, Xiaochen

“…Insect repellent N,N-diethyl-m-toluamide (DEET) and sunscreen oxybenzone are capable of enhancing skin permeation of each other when applied simultaneously. We…”
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Tissue disposition of the insect repellent DEET and the sunscreen oxybenzone following intravenous and topical administration in rats by Fediuk, Daryl J., Wang, Tao, Chen, Yufei, Parkinson, Fiona E., Namaka, Michael P., Simons, Keith J., Burczynski, Frank J., Gu, Xiaochen

“…ABSTRACT The insect repellent N,N‐diethyl‐m‐toluamide (DEET) and sunscreen oxybenzone (OBZ) have been shown to produce synergistic permeation enhancement when…”
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In-vitro permeation of the Insect repellent N,N-diethyl-m-toluamide (DEET) and the sunscreen oxybenzone by Gu, Xiaochen, Kasichayanula, Sreeneeranj, Fediuk, Daryl J., Burczynski, Frank J.

“…The permeation behaviours of the insect repellent N,N‐diethyl‐m‐toluamide (DEET) and the sunscreen oxybenzone were assessed in a series of in‐vitro diffusion…”
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Evaluation and Comparison of Five Matrix Excipients for the Controlled Release of Acrivastine and Pseudoephedrine by Gu, Xiaochen, Fediuk, Daryl J., Simons, F. Estelle R., Simons, Keith J.

“…For treatment of allergic rhinitis, acrivastine with pseudoephedrine in Semprex®-D conventional capsules requires dosing every 6-8 hours. This study was…”
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Tissue disposition of the insect repellent DEET and the sunscreen oxybenzone following intravenous and topical administration in rats: DISPOSITION OF DEET AND OXYBENZONE IN RATS by Fediuk, Daryl J., Wang, Tao, Chen, Yufei, Parkinson, Fiona E., Namaka, Michael P., Simons, Keith J., Burczynski, Frank J., Gu, Xiaochen

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