Search Results - "Federspiel, William J."

Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future by Cove, Matthew E, MacLaren, Graeme, Federspiel, William J, Kellum, John A

“…Acute respiratory distress syndrome (ARDS) has a substantial mortality rate and annually affects more than 140,000 people in the USA alone. Standard management…”
Get full text

A unified mathematical model for the prediction of controlled release from surface and bulk eroding polymer matrices by Rothstein, Sam N, Federspiel, William J, Little, Steven R

“…Abstract A unified model has been developed to predict release not only from bulk eroding and surface eroding systems but also from matrices that transition…”
Get full text

Fiber Bundle Design for an Integrated Wearable Artificial Lung by Madhani, Shalv P, Frankowski, Brian J, Federspiel, William J

“…Mechanical ventilation (MV) and extracorporeal membrane oxygenation (ECMO) are the only viable treatment options for lung failure patients at the end-stage,…”
Get full text

Improvement of a Mathematical Model to Predict CO2 Removal in Hollow Fiber Membrane Oxygenators by Omecinski, Katelin S., Federspiel, William J.

“…The use of extracorporeal oxygenation and CO2 removal has gained clinical validity and popularity in recent years. These systems are composed of a pump to…”
Get full text

Development of zwitterionic sulfobetaine block copolymer conjugation strategies for reduced platelet deposition in respiratory assist devices by Malkin, Alexander D, Ye, Sang-Ho, Lee, Evan J, Yang, Xiguang, Zhu, Yang, Gamble, Lara J, Federspiel, William J, Wagner, William R

“…Respiratory assist devices, that utilize ∼2 m of hollow fiber membranes (HFMs) to achieve desired gas transfer rates, have been limited in their adoption due…”
Get full text

In Vivo 5 Day Animal Studies of a Compact, Wearable Pumping Artificial Lung by Madhani, Shalv P, Frankowski, Brian J, Ye, Sang-Ho, Burgreen, Greg W, Wagner, William R, Kormos, Robert, D’Cunha, Jonathan, Federspiel, William J

“…Recent studies show improved outcomes in ambulated lung failure patients. Ambulation still remains a challenge in these patients. This necessitates development…”
Get full text

Subject-specific factors affecting particle residence time distribution of left atrial appendage in atrial fibrillation: A computational model-based study by Sanatkhani, Soroosh, Nedios, Sotirios, Menon, Prahlad G, Saba, Samir F, Jain, Sandeep K, Federspiel, William J, Shroff, Sanjeev G

“…Atrial fibrillation (AF) is a prevalent arrhythmia, that causes thrombus formation, ordinarily in the left atrial appendage (LAA). The conventional metric of…”
Get full text

Extracorporeal CO2 removal by hemodialysis: in vitro model and feasibility by May, Alexandra G., Sen, Ayan, Cove, Matthew E., Kellum, John A., Federspiel, William J.

“…Background Critically ill patients with acute respiratory distress syndrome and acute exacerbations of chronic obstructive pulmonary disease often develop…”
Get full text

Darcy Permeability of Hollow Fiber Membrane Bundles Made from Membrana Polymethylpentene Fibers Used in Respiratory Assist Devices by Madhani, Shalv P, D’Aloiso, Brandon D, Frankowski, Brian, Federspiel, William J

“…Hollow fiber membranes (HFMs) are used in blood oxygenators for cardiopulmonary bypass or in next generation artificial lungs. Flow analyses of these devices…”
Get full text

A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis by Malkin, Alexander D, Sheehan, Robert P, Mathew, Shibin, Federspiel, William J, Redl, Heinz, Clermont, Gilles

“…Neutrophils play a central role in eliminating bacterial pathogens, but may also contribute to end-organ damage in sepsis. Interleukin-8 (IL-8), a key…”
Get full text

Leukocyte capture and modulation of cell-mediated immunity during human sepsis: an ex vivo study by Rimmelé, Thomas, Kaynar, Ata Murat, McLaughlin, Joseph N, Bishop, Jeffery V, Fedorchak, Morgan V, Chuasuwan, Anan, Peng, Zhiyong, Singbartl, Kai, Frederick, Daniel R, Zhu, Lin, Carter, Melinda, Federspiel, William J, Zeevi, Adriana, Kellum, John A

“…Promising preclinical results have been obtained with blood purification therapies as adjuvant treatment for sepsis. However, the mechanisms by which these…”
Get full text

An extracorporeal carbon dioxide removal (ECCO2R) device operating at hemodialysis blood flow rates by Jeffries, R. Garrett, Lund, Laura, Frankowski, Brian, Federspiel, William J.

“…Background Extracorporeal carbon dioxide removal (ECCO 2 R) systems have gained clinical appeal as supplemental therapy in the treatment of acute and chronic…”
Get full text

Bench Validation of a Compact Low-Flow CO2 Removal Device by May, Alexandra G., Jeffries, R. Garrett, Frankowski, Brian J., Burgreen, Greg W., Federspiel, William J.

“…Background There is increasing evidence demonstrating the value of partial extracorporeal CO 2 removal (ECCO 2 R) for the treatment of hypercapnia in patients…”
Get full text

In vivo testing of the low-flow CO2 removal application of a compact, platform respiratory device by May, Alexandra G., Orizondo, Ryan A., Frankowski, Brian J., Ye, Sang-Ho, Kocyildirim, Ergin, Wagner, William R., D’Cunha, Jonathan, Federspiel, William J.

“…Background Non-invasive and lung-protective ventilation techniques may improve outcomes for patients with an acute exacerbation of chronic obstructive…”
Get full text

Towards improved artificial lungs through biocatalysis by Kaar, Joel L, Oh, Heung-Il, Russell, Alan J, Federspiel, William J

“…Abstract Inefficient CO2 removal due to limited diffusion represents a significant barrier in the development of artificial lungs and respiratory assist…”
Get full text

Design and In Vitro Evaluation of an Artificial Placenta Made From Hollow Fiber Membranes by Omecinski, Katelin S., Frankowski, Brian J., Federspiel, William J.

“…For infants born at the border of viability, care practices and morbimortality rates vary widely between centers. Trends show significant improvement, however,…”
Get full text

Machine Perfusion Deters Ischemia-Related Derangement of a Rodent Free Flap: Development of a Model by Orizondo, Ryan A., Bengur, Fuat Baris, Komatsu, Chiaki, Strong, Kelly R., Federspiel, William J., Solari, Mario G.

“…Machine perfusion can enable isolated support of composite tissues, such as free flaps. The goal of perfusion in this setting is to preserve tissues prior to…”
Get full text

High molecular weight blood group A trisaccharide-polyacrylamide glycoconjugates as synthetic blood group A antigens for anti-A antibody removal devices by Alikhani, Azadeh, Korchagina, Elena Y., Chinarev, Alexander A., Bovin, Nicolai V., Federspiel, William J.

“…Specific immunoadsorption of blood group antibodies by synthetic antigens immobilized on support matrices in the peri‐transplantation period provides a…”
Get full text

Epoxy silane sulfobetaine block copolymers for simple, aqueous thromboresistant coating on ambulatory assist lung devices by Ye, Sang-Ho, Orizondo, Ryan A, De, Bianca Nina, Kim, Seungil, Frankowski, Brian J, Federspiel, William J, Wagner, William R

“…Developing an ambulatory assist lung (AAL) for patients who need continuous extracorporeal membrane oxygenation has been associated with several design…”
Get full text

Respiratory dialysis: Reduction in dependence on mechanical ventilation by venovenous extracorporeal CO2 removal by Batchinsky, Andriy I, Jordan, Bryan S, Regn, Dara, Necsoiu, Corina, Federspiel, William J, Morris, Michael J, Cancio, Leopoldo C

“…OBJECTIVES:Mechanical ventilation is injurious to the lung. Use of lung-protective strategies may complicate patient management, motivating a search for better…”
Get full text