Search Results - "Federico, V."

Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression by Beltrán-García, Jesús, Osca-Verdegal, Rebeca, Pallardó, Federico V., Ferreres, José, Rodríguez, María, Mulet, Sandra, Sanchis-Gomar, Fabian, Carbonell, Nieves, García-Giménez, José Luis

“…Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak emerged, countless efforts are being made worldwide to understand the molecular…”
Get full text

A nuclear glutathione cycle within the cell cycle by Diaz Vivancos, Pedro, Wolff, Tonja, Markovic, Jelena, Pallardó, Federico V, Foyer, Christine H

“…The complex antioxidant network of plant and animal cells has the thiol tripeptide GSH at its centre to buffer ROS (reactive oxygen species) and facilitate…”
Get more information

Sepsis and Coronavirus Disease 2019: Common Features and Anti-Inflammatory Therapeutic Approaches by Beltrán-García, Jesús, Osca-Verdegal, Rebeca, Pallardó, Federico V., Ferreres, José, Rodríguez, María, Mulet, Sandra, Ferrando-Sánchez, Carolina, Carbonell, Nieves, García-Giménez, José Luis

“…Great efforts are being made worldwide to identify the specific clinical characteristics of infected critically ill patients that mediate the associated…”
Get full text

Role of glutathione in the regulation of epigenetic mechanisms in disease by García-Giménez, José Luis, Romá-Mateo, Carlos, Pérez-Machado, Gisselle, Peiró-Chova, Lorena, Pallardó, Federico V.

“…Epigenetics is a rapidly growing field that studies gene expression modifications not involving changes in the DNA sequence. Histone H3, one of the basic…”
Get full text

Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats by Gomez‐Cabrera, Mari‐Carmen, Borrás, Consuelo, Pallardó, Federico V., Sastre, Juan, Ji, Li Li, Viña, Jose

“…Reactive oxygen or nitrogen species (RONS) are produced during exercise due, at least in part, to the activation of xanthine oxidase. When exercise is…”
Get full text

PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia by Rodríguez-Pascau, Laura, Britti, Elena, Calap-Quintana, Pablo, Dong, Yi Na, Vergara, Cristina, Delaspre, Fabien, Medina-Carbonero, Marta, Tamarit, Jordi, Pallardó, Federico V., Gonzalez-Cabo, Pilar, Ros, Joaquim, Lynch, David R., Martinell, Marc, Pizcueta, Pilar

“…Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is characterized by degeneration of the large sensory neurons and spinocerebellar tracts,…”
Get full text

Direct antioxidant and protective effect of estradiol on isolated mitochondria by Borrás, Consuelo, Gambini, Juan, López-Grueso, Raúl, Pallardó, Federico V., Viña, Jose

“…Estrogens have antioxidant properties which are due to their ability to bind to estrogen receptors and to up-regulate the expression of antioxidant enzymes via…”
Get full text

Mitochondrial dysfunction in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome: prospect use of antioxidants and mitochondrial nutrients by Pagano, Giovanni, Lyakhovich, Alex, Pallardó, Federico V., Tiano, Luca, Zatterale, Adriana, Trifuoggi, Marco

“…Fragile X syndrome (FXS) is a genetic disorder characterized by mutation in the FMR1 gene, leading to the absence or reduced levels of fragile X Messenger…”
Get full text

Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures by Pagano, Giovanni, Pallardó, Federico V, Lyakhovich, Alex, Tiano, Luca, Fittipaldi, Maria Rosa, Toscanesi, Maria, Trifuoggi, Marco

“…A number of aging-related disorders (ARD) have been related to oxidative stress (OS) and mitochondrial dysfunction (MDF) in a well-established body of…”
Get full text

Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies by Zatterale, Adriana, Tiano, Luca, Pallardó, Federico V., Gadaleta, Maria Nicola, d’Ischia, Marco, Cordero, Mario D., Castello, Giuseppe, Aiello Talamanca, Annarita, Pagano, Giovanni, Petrović, Sandra

“…Beyond the disorders recognized as mitochondrial diseases, abnormalities in function and/or ultrastructure of mitochondria have been reported in several…”
Get full text

Mitigating the pro-oxidant state and melanogenesis of Retinitis pigmentosa: by counteracting mitochondrial dysfunction by Pagano, Giovanni, Pallardó, Federico V., Lyakhovich, Alex, Tiano, Luca, Trifuoggi, Marco

“…Retinitis pigmentosa (RP) is a group of mitochondrial diseases characterized by progressive degeneration of rods and cones leading to retinal loss of light…”
Get full text

Epigenetic biomarkers: Current strategies and future challenges for their use in the clinical laboratory by García-Giménez, José Luis, Seco-Cervera, Marta, Tollefsbol, Trygve O., Romá-Mateo, Carlos, Peiró-Chova, Lorena, Lapunzina, Pablo, Pallardó, Federico V.

“…Epigenetic modifications and regulators represent potential molecular elements which control relevant physiological and pathological features, thereby…”
Get full text

Recruitment of glutathione into the nucleus during cell proliferation adjusts whole‐cell redox homeostasis in Arabidopsis thaliana and lowers the oxidative defence shield by Vivancos, Pedro Diaz, Dong, Yingping, Ziegler, Kerstin, Markovic, Jelena, Pallardó, Federico V, Pellny, Till K, Verrier, Paul J, Foyer, Christine H

“…Cellular redox homeostasis and signalling are important in progression of the eukaryotic cell cycle. In animals, the low‐molecular‐weight thiol tripeptide…”
Get full text

Cofilin dysregulation alters actin turnover in frataxin-deficient neurons by Muñoz-Lasso, Diana C., Mollá, Belén, Calap-Quintana, Pablo, García-Giménez, José Luis, Pallardo, Federico V., Palau, Francesc, Gonzalez-Cabo, Pilar

“…Abnormalities in actin cytoskeleton have been linked to Friedreich’s ataxia (FRDA), an inherited peripheral neuropathy characterised by an early loss of…”
Get full text

Mitochondrial biogenesis in health and disease. Molecular and therapeutic approaches by Sanchis-Gomar, Fabian, García-Giménez, José Luis, Gómez-Cabrera, Mari Carmen, Pallardó, Federico V

“…Mitochondrial biogenesis (MB) is the essential mechanism by which cells control the number of mitochondria. Cells respond to different physiologic, metabolic,…”
Get more information

Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders by Muñoz-Lasso, Diana C, Romá-Mateo, Carlos, Pallardó, Federico V, Gonzalez-Cabo, Pilar

“…Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some…”
Get full text

miRNAs Related to Immune Checkpoint Inhibitor Response: A Systematic Review by García-Giménez, José Luis, Saadi, Wiam, Ortega, Angel L, Lahoz, Agustin, Suay, Guillermo, Carretero, Julián, Pereda, Javier, Fatmi, Ahlam, Pallardó, Federico V, Mena-Molla, Salvador

“…The advent of immune checkpoint inhibitors (ICIs) has represented a breakthrough in the treatment of many cancers, although a high number of patients fail to…”
Get full text

Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance by Gomez-Cabrera, Mari-Carmen, Domenech, Elena, Romagnoli, Marco, Arduini, Alessandro, Borras, Consuelo, Pallardo, Federico V, Sastre, Juan, Viña, Jose

“…Exercise practitioners often take vitamin C supplements because intense muscular contractile activity can result in oxidative stress, as indicated by altered…”
Get full text

Role of microRNAs As Biomarkers in Sepsis-Associated Encephalopathy by Osca-Verdegal, Rebeca, Beltrán-García, Jesús, Pallardó, Federico V., García-Giménez, José Luis

“…Sepsis-associated encephalopathy (SAE) is a neurological complication of sepsis, characterized by brain dysfunction without any direct central nervous system…”
Get full text

Alterations in leukocyte DNA methylome are associated to immunosuppression in severe clinical phenotypes of septic patients by Beltrán-García, Jesús, Casabó-Vallés, Germán, Osca-Verdegal, Rebeca, Navarrete-López, Paula, Rodriguez-Gimillo, María, Nacher-Sendra, Elena, Ferrando-Sánchez, Carolina, García-López, Eva, Pallardó, Federico V, Carbonell, Nieves, Mena-Mollá, Salvador, García-Giménez, José Luis

“…Sepsis patients experience a complex interplay of host pro- and anti-inflammatory processes which compromise the clinical outcome. Despite considering the…”
Get full text