Search Results - "Federico, Giorgia"

NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice by Nai, Antonella, Lidonnici, Maria Rosa, Federico, Giorgia, Pettinato, Mariateresa, Olivari, Violante, Carrillo, Federica, Geninatti Crich, Simonetta, Ferrari, Giuliana, Camaschella, Clara, Silvestri, Laura, Carlomagno, Francesca

“…Nuclear receptor coactivator 4 (NCOA4) promotes ferritin degradation and Ncoa4-ko mice in a C57BL/6 background show microcytosis and mild anemia, aggravated by…”
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NCOA4 Deficiency Impairs Systemic Iron Homeostasis by Bellelli, Roberto, Federico, Giorgia, Matte’, Alessandro, Colecchia, David, Iolascon, Achille, Chiariello, Mario, Santoro, Massimo, De Franceschi, Lucia, Carlomagno, Francesca

“…The cargo receptor NCOA4 mediates autophagic ferritin degradation. Here we show that NCOA4 deficiency in a knockout mouse model causes iron accumulation in the…”
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Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases by Moccia, Marialuisa, Yang, Donglin, Lakkaniga, Naga Rajiv, Frett, Brendan, McConnell, Nicholas, Zhang, Lingtian, Brescia, Annalisa, Federico, Giorgia, Zhang, Lingzhi, Salerno, Paolo, Santoro, Massimo, Li, Hong-yu, Carlomagno, Francesca

“…We have recently described Pz-1, a benzimidazole-based type-2 RET and VEGFR2 inhibitor. Based on a kinome scan, here we show that Pz-1 is also a potent (IC 50 …”
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Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology by Moccia, Marialuisa, Frett, Brendan, Zhang, Lingtian, Lakkaniga, Naga Rajiv, Briggs, David C, Chauhan, Rakhee, Brescia, Annalisa, Federico, Giorgia, Yan, Wei, Santoro, Massimo, McDonald, Neil Q, Li, Hong-yu, Carlomagno, Francesca

“…RET receptor tyrosine kinase is a driver oncogene in human cancer. We recently identified the clinical drug candidate Pz-1, which targets RET and VEGFR2. A key…”
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Tamoxifen erythroid toxicity revealed by studying the role of nuclear receptor co-activator 4 in erythropoiesis by Nai, Antonella, Pettinato, Mariateresa, Federico, Giorgia, Olivari, Violante, Carlomagno, Francesca, Silvestri, Laura

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Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology by Frett, Brendan, Carlomagno, Francesca, Moccia, Maria Luisa, Brescia, Annalisa, Federico, Giorgia, De Falco, Valentina, Admire, Brittany, Chen, Zhongzhu, Qi, Wenqing, Santoro, Massimo, Li, Hong-yu

“…Oncogenic conversion of the RET (rearranged during transfection) tyrosine kinase is associated with several cancers. A fragment‐based chemical screen led to…”
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Iron and Ferritin Modulate MHC Class I Expression and NK Cell Recognition by Sottile, Rosa, Federico, Giorgia, Garofalo, Cinzia, Tallerico, Rossana, Faniello, Maria Concetta, Quaresima, Barbara, Cristiani, Costanza Maria, Di Sanzo, Maddalena, Cuda, Gianni, Ventura, Valeria, Wagner, Arnika Kathleen, Contrò, Gianluca, Perrotti, Nicola, Gulletta, Elio, Ferrone, Soldano, Kärre, Klas, Costanzo, Francesco Saverio, Carlomagno, Francesca, Carbone, Ennio

“…The ability of pathogens to sequester iron from their host cells and proteins affects their virulence. Moreover, iron is required for various innate host…”
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Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase by Moccia, Marialuisa, Liu, Qingsong, Guida, Teresa, Federico, Giorgia, Brescia, Annalisa, Zhao, Zheng, Choi, Hwan Geun, Deng, Xianming, Tan, Li, Wang, Jinhua, Billaud, Marc, Gray, Nathanael S, Carlomagno, Francesca, Santoro, Massimo

“…Oncogenic mutation of the RET receptor tyrosine kinase is observed in several human malignancies. Here, we describe three novel type II RET tyrosine kinase…”
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RET Gene Fusions in Malignancies of the Thyroid and Other Tissues by Santoro, Massimo, Moccia, Marialuisa, Federico, Giorgia, Carlomagno, Francesca

“…Following the identification of the BCR-ABL1 (Breakpoint Cluster Region-ABelson murine Leukemia) fusion in chronic myelogenous leukemia, gene fusions…”
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NCOA4 links iron bioavailability to DNA metabolism by Federico, Giorgia, Carrillo, Federica, Dapporto, Francesca, Chiariello, Mario, Santoro, Massimo, Bellelli, Roberto, Carlomagno, Francesca

“…Iron is essential for deoxyribonucleotides production and for enzymes containing an Fe-S cluster involved in DNA replication and repair. How iron…”
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The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model by Matte, Alessandro, Federti, Enrica, Kung, Charles, Kosinski, Penelope A, Narayanaswamy, Rohini, Russo, Roberta, Federico, Giorgia, Carlomagno, Francesca, Desbats, Maria Andrea, Salviati, Leonardo, Leboeuf, Christophe, Valenti, Maria Teresa, Turrini, Francesco, Janin, Anne, Yu, Shaoxia, Beneduce, Elisabetta, Ronseaux, Sebastien, Iatcenko, Iana, Dang, Lenny, Ganz, Tomas, Jung, Chun-Ling, Iolascon, Achille, Brugnara, Carlo, De Franceschi, Lucia

“…Anemia in β-thalassemia is related to ineffective erythropoiesis and reduced red cell survival. Excess free heme and accumulation of unpaired α-globin chains…”
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NCOA4 Links Iron Bioavailability to DNA Metabolism by Federico, Giorgia, Bellelli, Roberto, Nai, Antonella, Silvestri, Laura, Camaschella, Clara, Iolascon, Achille, Santoro, Massimo, Carlomagno, Francesca

“…Iron (Fe) is a key element of many proteins involved in primary cellular processes such as energy production, DNA synthesis and repair (Fuss et al. 2015)…”
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Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis by Matte, Alessandro, De Falco, Luigia, Federti, Enrica, Cozzi, Anna, Iolascon, Achille, Levi, Sonia, Mohandas, Narla, Zamo, Alberto, Bruno, Mariasole, Lebouef, Christophe, Janin, Anne, Siciliano, Angela, Ganz, Tom, Federico, Giorgia, Carlomagno, Francesca, Mueller, Sebastian, Silva, Ines, Carbone, Carmine, Melisi, Davide, Kim, Dae Won, Choi, Soo Young, De Franceschi, Lucia

“…Iron overload (IO) is a life-threatening complication of chronic hemolytic disorders such as β-thalassemia. IO results in severe cellular oxidative damage,…”
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The Macrophage Nuclear Receptor Coactivator 4 Counteracts Iron-Deficiency Anemia by Nai, Antonella, Lidonnici, Maria Rosa, Artuso, Irene, Federico, Giorgia, Mandelli, Giacomo, Ferrari, Giuliana, Camaschella, Clara, Carlomagno, Francesca, Silvestri, Laura

“…The Nuclear Receptor Coactivator 4 (NCOA4) protein has been recently recognized as a novel player in iron metabolism contributing to regulation of cell and…”
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Iron and Ferritin Modulate MHC Class I Expression and NK Cells Recognition by Sottile, R, Federico, G, Garofalo, C, Tallerico, R, Faniello, MC, Quaresima, B, Cristiani, CM, Di, Sanzo M, Cuda, G, Ventura, V

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The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a [beta]-thalassemia mouse model by Matte, Alessandro, Federti, Enrica, Kung, Charles, Kosinski, Penelope A, Narayanaswamy, Rohini, Russo, Roberta, Federico, Giorgia, Carlomagno, Francesca, Desbats, Maria Andrea, Salviati, Leonardo, Leboeuf, Christophe, Valenti, Maria Teresa, Turrini, Francesco, Janin, Anne, Yu, Shaoxia, Beneduce, Elisabetta, Ronseaux, Sebastien, Iatcenko, Iana, Dang, Lenny, Ganz, Tomas, Jung, Chun-Ling, Iolascon, Achille, Brugnara, Carlo, De Franceschi, Lucia

“…Anemia in [beta]-thalassemia is related to ineffective erythropoiesis and reduced red cell survival. Excess free heme and accumulation of unpaired…”
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Oncogene-induced senescence and its evasion in a mouse model of thyroid neoplasia by Bellelli, Roberto, Vitagliano, Donata, Federico, Giorgia, Marotta, Pina, Tamburrino, Anna, Salerno, Paolo, Paciello, Orlando, Papparella, Serenella, Knauf, Jeffrey A., Fagin, James A., Refetoff, Samuel, Troncone, Giancarlo, Santoro, Massimo

“…Here we describe a conditional doxycycline-dependent mouse model of RET/PTC3 (NCOA4-RET) oncogene-induced thyroid tumorigenesis. In these mice, after 10 days…”
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The chemokine scavenging receptor D6/ACKR2 is a target of miR-146a in thyroid cancer by Pacifico, Francesco, Lepore, Alessio, Mellone, Stefano, Sanguigno, Luca, Federico, Giorgia, Greco, Adelaide, Brunetti, Arturo, Leonardi, Antonio

“…We have previously shown that miR-146a, a NF-κB-regulated microRNA, is strongly expressed in human specimens and cell lines derived from anaplastic thyroid…”
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Fragment-based discovery of a dual pan-RET/VEGFR2 kinase inhibitor optimized for single-agent polypharmacology1 by Frett, Brendan, Carlomagno, Francesca, Moccia, Maria Luisa, Brescia, Annalisa, Federico, Giorgia, De Falco, Valentina, Admire, Brittany, Chen, Zhongzhu, Qi, Wenqing, Santoro, Massimo, Li, Hong-yu

“…Oncogenic conversion of the RET (rearranged during transfection) tyrosine kinase is associated with several cancers. A fragment-based chemical screen lead to…”
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Peroxiredoxin-2: A Novel Factor Involved in Iron Homeostasis by Mattè, Alessandro, De Falco, Luigia, Federti, Enrica, Levi, Sonia, Iolascon, Achille, Federico, Giorgia, Mohandas, Narla, Janin, Anne, Bruno, Mariasole, Leboeuf, Christophe, Choi, Soo Young, Kim, Dae Won, Dima, Francesco, Siciliano, Angela, De Franceschi, Lucia

“…Peroxiredoxin-2 (Prx2), a typical 2-cysteine (Cys) peroxiredoxin, is a key anti-oxidant system in both normal and pathological erythropoiesis characterized by…”
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