Search Results - "Federico, F."
-
1
Transcriptome analysis of highly purified mouse spermatogenic cell populations: gene expression signatures switch from meiotic-to postmeiotic-related processes at pachytene stage
Published in BMC genomics (19-04-2016)“…Spermatogenesis is a complex differentiation process that involves the successive and simultaneous execution of three different gene expression programs:…”
Get full text
Journal Article -
2
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
Published in Cell (20-01-2022)“…The liver is the largest solid organ in the body, yet it remains incompletely characterized. Here we present a spatial proteogenomic atlas of the healthy and…”
Get full text
Journal Article -
3
Vesicular release statistics and unitary postsynaptic current at single GABAergic synapses
Published in Neuron (Cambridge, Mass.) (07-01-2015)“…The existence of vesicular docking sites in central synapses is supported by morphological and biochemical evidence, but their functional role remains elusive…”
Get full text
Journal Article -
4
Optogenetic dissection of Rac1 and Cdc42 gradient shaping
Published in Nature communications (16-11-2018)“…During cell migration, Rho GTPases spontaneously form spatial gradients that define the front and back of cells. At the front, active Cdc42 forms a steep…”
Get full text
Journal Article -
5
A breath of fresh macrophages ameliorates inflammation in the hypoxic lung
Published in Nature immunology (01-06-2022)“…Hypoxia alters populations of monocytes and macrophages during acute respiratory distress syndrome leading to persistent inflammation, a process that can be…”
Get full text
Journal Article -
6
Antidromic Analog Signaling
Published in Frontiers in cellular neuroscience (02-08-2019)“…Analog signaling describes the use of graded voltage changes as signals in the axonal compartment. Analog signaling has been described originally in…”
Get full text
Journal Article -
7
In matters of the heart, (cellular) communication is key
Published in Immunity (Cambridge, Mass.) (14-09-2021)“…To maintain cardiac output, the failing heart undergoes significant remodeling. However, the mechanisms regulating this remain unclear. In this issue of…”
Get full text
Journal Article -
8
Axonal GABAA receptors depolarize presynaptic terminals and facilitate transmitter release in cerebellar Purkinje cells
Published in The Journal of physiology (15-12-2017)“…Key points GABAA receptors have been described in the axonal compartment of neurons; contrary to dendritic GABAA receptors, axonal GABAA receptors usually…”
Get full text
Journal Article -
9
Kupffer Cells Contested as Early Drivers in the Pathogenesis of Primary Sclerosing Cholangitis
Published in The American journal of pathology (01-04-2023)“…Primary sclerosing cholangitis (PSC) is an idiopathic chronic immune-mediated cholestatic liver disease characterized by fibro-inflammatory bile duct…”
Get full text
Journal Article -
10
MultiPhen: joint model of multiple phenotypes can increase discovery in GWAS
Published in PloS one (02-05-2012)“…The genome-wide association study (GWAS) approach has discovered hundreds of genetic variants associated with diseases and quantitative traits. However,…”
Get full text
Journal Article -
11
Familial primary ovarian insufficiency associated with an SYCE1 point mutation: defective meiosis elucidated in humanized mice
Published in Molecular human reproduction (01-07-2020)“…Abstract More than 50% of cases of primary ovarian insufficiency (POI) and nonobstructive azoospermia in humans are classified as idiopathic infertility…”
Get full text
Journal Article -
12
Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming
Published in Immunity (Cambridge, Mass.) (14-09-2021)“…Kupffer cells (KCs) are highly abundant, intravascular, liver-resident macrophages known for their scavenger and phagocytic functions. KCs can also present…”
Get full text
Journal Article -
13
Developing a common approach for classifying building stock energy models
Published in Renewable & sustainable energy reviews (01-11-2020)“…Buildings contribute 40% of global greenhouse gas emissions; therefore, strategies that can substantially reduce emissions from the building stock are key…”
Get full text
Journal Article -
14
Revealing stage-specific expression patterns of long noncoding RNAs along mouse spermatogenesis
Published in RNA biology (03-03-2020)“…The discovery of a large number of long noncoding RNAs (lncRNAs), and the finding that they may play key roles in different biological processes, have started…”
Get full text
Journal Article -
15
Performance of a new generation balloon expandable stent-graft (Gore VBX) as bridging stent for B-EVAR
Published in Journal of cardiovascular surgery (17-09-2024)“…The aim of this study was to report the results of a single-centre experience with a new generation balloon expandable stent-graft (Viabahn VBX; W. L. Gore &…”
Get full text
Journal Article -
16
Axonal GABA A receptors depolarize presynaptic terminals and facilitate transmitter release in cerebellar Purkinje cells
Published in The Journal of physiology (15-12-2017)“…GABA receptors have been described in the axonal compartment of neurons; contrary to dendritic GABA receptors, axonal GABA receptors usually induce…”
Get full text
Journal Article -
17
Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis
Published in Hepatology (Baltimore, Md.) (01-02-2024)“…Primary sclerosing cholangitis (PSC) is an immune-mediated cholestatic liver disease for which pharmacological treatment options are currently unavailable. PSC…”
Get full text
Journal Article -
18
Vascular responsiveness determined by near‐infrared spectroscopy measures of oxygen saturation
Published in Experimental physiology (01-01-2016)“…New Findings What is the central question of this study? Can the near‐infrared spectroscopy (NIRS)‐derived reperfusion rate (slope 2) of tissue oxygen…”
Get full text
Journal Article -
19
Differentially poised vesicles underlie fast and slow components of release at single synapses
Published in The Journal of general physiology (04-05-2020)“…In several types of central mammalian synapses, sustained presynaptic stimulation leads to a sequence of two components of synaptic vesicle release, reflecting…”
Get full text
Journal Article -
20
Understanding the complex macrophage landscape in MASLD
Published in JHEP reports (01-11-2024)“…Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a spectrum of disease states ranging from simple steatosis to metabolic…”
Get full text
Journal Article