A comparative study of the action of preparations of high- and low-molecular weight heparin on hemostatic indices in vitro and in their intravenous administration to animals

Low-molecular heparin preparations (a Soviet sample and that manufactured by the Celsus Company) in vitro, added to bovine plasma possess a lower antifactor-II activity, less time of recalcification and partial thromboplastin time as compared to high-molecular heparin of equal concentration (mg/ml)...

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Bibliographic Details
Published in:	Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 55; no. 1; p. 35
Main Authors:	Kudriashov, B A, Pastorova, V E, Liapina, L A, Kondashevskaia, M V, Azieva, L D, Sukhanov, Iu S, Fedeniuk, P V, Vasiukov, S E, Cherstvova, L G
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-1992
Subjects:	Animals Blood Coagulation Tests Fibrinolysis - drug effects Hemostasis - drug effects Heparin - administration & dosage Heparin - pharmacology Heparin, Low-Molecular-Weight - administration & dosage Heparin, Low-Molecular-Weight - pharmacology Injections, Intravenous Male Molecular Weight Rats Time Factors
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Summary:	Low-molecular heparin preparations (a Soviet sample and that manufactured by the Celsus Company) in vitro, added to bovine plasma possess a lower antifactor-II activity, less time of recalcification and partial thromboplastin time as compared to high-molecular heparin of equal concentration (mg/ml) or dose (Units/ml). After intravenous injection of low-molecular heparin preparations to animals in a dose of 50 Units/200 g bw the time of hemorrhage was far less, while anticoagulant activity was lower than in animals given the same dose of high-molecular heparin. Both injection of low-molecular and high-molecular heparin results in a rise of the intensity of non-enzymatic fibrinolysis in the animals' blood plasma.
ISSN:	0869-2092