Search Results - "Feary, Marc"

CHOK1SV GS‐KO SSI expression system: A combination of the Fer1L4 locus and glutamine synthetase selection by Feary, Marc, Moffat, Mark A., Casperson, Gerald F., Allen, Martin J., Young, Robert J.

“…There are an ever‐increasing number of biopharmaceutical candidates in clinical trials fueling an urgent need to streamline the cell line development process…”
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Methionine sulfoximine supplementation enhances productivity in GS–CHOK1SV cell lines through glutathione biosynthesis by Feary, Marc, Racher, Andrew J., Young, Robert J., Smales, C. Mark

“…In Lonza Biologics' GS Gene Expression System™, recombinant protein‐producing GS–CHOK1SV cell lines are generated by transfection with an expression vector…”
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Biological insights into the expression of translation initiation factors from recombinant CHOK1SV cell lines and their relationship to enhanced productivity by Mead, Emma J, Masterton, Rosalyn J, Feary, Marc, Obrezanova, Olga, Zhang, Lin, Young, Robert, Smales, C Mark

“…Translation initiation is on the critical pathway for the production of monoclonal antibodies (mAbs) by mammalian cells. Formation of a closed loop structure…”
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Rapid high-throughput characterisation, classification and selection of recombinant mammalian cell line phenotypes using intact cell MALDI-ToF mass spectrometry fingerprinting and PLS-DA modelling by Povey, Jane F., O’Malley, Christopher J., Root, Tracy, Martin, Elaine B., Montague, Gary A., Feary, Marc, Trim, Carol, Lang, Dietmar A., Alldread, Richard, Racher, Andrew J., Smales, C. Mark

“…•Methodology for prediction of CHO cell productivity early in cell line development.•Development of a CHO cell MALDI-ToF fingerprint database.•Evaluation of…”
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