Search Results - "Feany, Mel"

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  1. 1

    Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo by DuBoff, Brian, Götz, Jürgen, Feany, Mel B.

    Published in Neuron (Cambridge, Mass.) (23-08-2012)
    “…Mitochondrial abnormalities have been documented in Alzheimer’s disease and related neurodegenerative disorders, but the causal relationship between…”
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  2. 2

    Lamin Dysfunction Mediates Neurodegeneration in Tauopathies by Frost, Bess, Bardai, Farah H., Feany, Mel B.

    Published in Current biology (11-01-2016)
    “…The filamentous meshwork formed by the lamin nucleoskeleton provides a scaffold for the anchoring of highly condensed heterochromatic DNA to the nuclear…”
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  3. 3

    Tau promotes neurodegeneration through global chromatin relaxation by Frost, Bess, Hemberg, Martin, Lewis, Jada, Feany, Mel B

    Published in Nature neuroscience (01-03-2014)
    “…The authors show that there is global loss of heterochromatin in tau transgenic Drosophila and mice, and post-mortem brain from Alzheimer's disease patients…”
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  4. 4

    α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton by Ordonez, Dalila G., Lee, Michael K., Feany, Mel B.

    Published in Neuron (Cambridge, Mass.) (03-01-2018)
    “…Genetics and neuropathology strongly link α-synuclein aggregation and neurotoxicity to the pathogenesis of Parkinson’s disease and related α-synucleinopathies…”
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  5. 5

    α-synuclein impairs autophagosome maturation through abnormal actin stabilization by Sarkar, Souvarish, Olsen, Abby L, Sygnecka, Katja, Lohr, Kelly M, Feany, Mel B

    Published in PLoS genetics (01-02-2021)
    “…Vesicular trafficking defects, particularly those in the autophagolysosomal system, have been strongly implicated in the pathogenesis of Parkinson's disease…”
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  6. 6

    Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency by Nithianandam, Vanitha, Sarkar, Souvarish, Feany, Mel B

    Published in Human molecular genetics (04-05-2024)
    “…Abstract Neuromuscular disorders caused by dysfunction of the mitochondrial respiratory chain are common, severe and untreatable. We recovered a number of…”
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  7. 7

    Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics by Bardai, Farah H, Ordonez, Dalila G, Bailey, Rachel M, Hamm, Matthew, Lewis, Jada, Feany, Mel B

    Published in PLoS biology (20-12-2018)
    “…Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson disease. Genetics and neuropathology link Parkinson disease…”
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  8. 8

    Precision Medicine on the Fly: Using Drosophila to Decipher Gene-Environment Interactions in Parkinson’s Disease by Sarkar, Souvarish, Feany, Mel B

    Published in Toxicological sciences (03-08-2021)
    “…Abstract Big data approaches have profoundly influenced state-of-the-art in many fields of research, with toxicology being no exception. Here, we use…”
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  9. 9

    Parkinson's disease risk genes act in glia to control neuronal α-synuclein toxicity by Olsen, Abby L., Feany, Mel B.

    Published in Neurobiology of disease (01-11-2021)
    “…Idiopathic Parkinson's disease is the second most common neurodegenerative disease and is estimated to be approximately 30% heritable. Genome wide association…”
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  10. 10

    Connecting the dots between tau dysfunction and neurodegeneration by Frost, Bess, Götz, Jürgen, Feany, Mel B

    Published in Trends in cell biology (01-01-2015)
    “…Highlights • Downstream mechanisms of tau neurotoxicity are discussed. • Tau drives cytoskeletal, mitochondrial, chromatin, and cell cycle dysfunction. •…”
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  11. 11

    Why size matters – balancing mitochondrial dynamics in Alzheimer's disease by DuBoff, Brian, Feany, Mel, Götz, Jürgen

    Published in Trends in neurosciences (Regular ed.) (01-06-2013)
    “…Highlights • Mitochondria provide energy, buffer calcium ions, and regulate apoptosis. • Mitochondrial dynamics is the term describing their regulated fusion…”
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  12. 12

    Parkinson's disease: genetics and pathogenesis by Shulman, Joshua M, De Jager, Philip L, Feany, Mel B

    Published in Annual review of pathology (01-01-2011)
    “…Recent investigation into the mechanisms of Parkinson's disease (PD) has generated remarkable insight while simultaneously challenging traditional conceptual…”
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  13. 13

    α-Synuclein Promotes Neuronal Dysfunction and Death by Disrupting the Binding of Ankyrin to β-Spectrin by Maor, Gali, Dubreuil, Ronald R, Feany, Mel B

    Published in The Journal of neuroscience (01-03-2023)
    “…α-Synuclein plays a key role in the pathogenesis of Parkinson's disease and related disorders, but critical interacting partners and molecular mechanisms…”
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  14. 14
  15. 15

    Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model by Lohr, Kelly M., Frost, Bess, Scherzer, Clemens, Feany, Mel B.

    “…Mitochondrial and metabolic dysfunction are often implicated in neurological disease, but effective mechanism-based therapies remain elusive. We performed a…”
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  16. 16

    The unfolded protein response protects from tau neurotoxicity in vivo by Loewen, Carin A, Feany, Mel B

    Published in PloS one (29-09-2010)
    “…The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in…”
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  17. 17

    PARP Inhibitors and Parkinson’s Disease by Olsen, Abby L, Feany, Mel B

    Published in The New England journal of medicine (31-01-2019)
    “…A recent study implicates the enzyme poly(adenosine 5′-diphosphate-ribose) polymerase 1 (PARP1) as a mediator of neuronal cell death in Parkinson’s disease…”
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  18. 18

    α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity by KONTOPOULOS, Eirene, PARVIN, Jeffrey D, FEANY, Mel B

    Published in Human molecular genetics (15-10-2006)
    “…Alpha-synuclein is a neuronal protein implicated genetically in Parkinson's disease. alpha-synuclein localizes to the nucleus and presynaptic nerve terminals…”
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  19. 19

    Glial α‐synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo by Olsen, Abby L., Feany, Mel B.

    Published in Glia (01-10-2019)
    “…α‐Synucleinopathies are neurodegenerative diseases that are characterized pathologically by α‐synuclein inclusions in neurons and glia. The pathologic…”
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  20. 20

    Elevated Oxidative Stress and DNA Damage in Cortical Neurons of Chemotherapy Patients by Torre, Matthew, Dey, Adwitia, Woods, Jared K, Feany, Mel B

    “…Abstract The unintended neurologic sequelae of chemotherapy contribute to significant patient morbidity. Chemotherapy-related cognitive impairment (CRCI) is…”
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