Search Results - "Feany, Mel"
-
1
Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo
Published in Neuron (Cambridge, Mass.) (23-08-2012)“…Mitochondrial abnormalities have been documented in Alzheimer’s disease and related neurodegenerative disorders, but the causal relationship between…”
Get full text
Journal Article -
2
Lamin Dysfunction Mediates Neurodegeneration in Tauopathies
Published in Current biology (11-01-2016)“…The filamentous meshwork formed by the lamin nucleoskeleton provides a scaffold for the anchoring of highly condensed heterochromatic DNA to the nuclear…”
Get full text
Journal Article -
3
Tau promotes neurodegeneration through global chromatin relaxation
Published in Nature neuroscience (01-03-2014)“…The authors show that there is global loss of heterochromatin in tau transgenic Drosophila and mice, and post-mortem brain from Alzheimer's disease patients…”
Get full text
Journal Article -
4
α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton
Published in Neuron (Cambridge, Mass.) (03-01-2018)“…Genetics and neuropathology strongly link α-synuclein aggregation and neurotoxicity to the pathogenesis of Parkinson’s disease and related α-synucleinopathies…”
Get full text
Journal Article -
5
α-synuclein impairs autophagosome maturation through abnormal actin stabilization
Published in PLoS genetics (01-02-2021)“…Vesicular trafficking defects, particularly those in the autophagolysosomal system, have been strongly implicated in the pathogenesis of Parkinson's disease…”
Get full text
Journal Article -
6
Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency
Published in Human molecular genetics (04-05-2024)“…Abstract Neuromuscular disorders caused by dysfunction of the mitochondrial respiratory chain are common, severe and untreatable. We recovered a number of…”
Get full text
Journal Article -
7
Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics
Published in PLoS biology (20-12-2018)“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson disease. Genetics and neuropathology link Parkinson disease…”
Get full text
Journal Article -
8
Precision Medicine on the Fly: Using Drosophila to Decipher Gene-Environment Interactions in Parkinson’s Disease
Published in Toxicological sciences (03-08-2021)“…Abstract Big data approaches have profoundly influenced state-of-the-art in many fields of research, with toxicology being no exception. Here, we use…”
Get full text
Journal Article -
9
Parkinson's disease risk genes act in glia to control neuronal α-synuclein toxicity
Published in Neurobiology of disease (01-11-2021)“…Idiopathic Parkinson's disease is the second most common neurodegenerative disease and is estimated to be approximately 30% heritable. Genome wide association…”
Get full text
Journal Article -
10
Connecting the dots between tau dysfunction and neurodegeneration
Published in Trends in cell biology (01-01-2015)“…Highlights • Downstream mechanisms of tau neurotoxicity are discussed. • Tau drives cytoskeletal, mitochondrial, chromatin, and cell cycle dysfunction. •…”
Get full text
Journal Article -
11
Why size matters – balancing mitochondrial dynamics in Alzheimer's disease
Published in Trends in neurosciences (Regular ed.) (01-06-2013)“…Highlights • Mitochondria provide energy, buffer calcium ions, and regulate apoptosis. • Mitochondrial dynamics is the term describing their regulated fusion…”
Get full text
Journal Article -
12
Parkinson's disease: genetics and pathogenesis
Published in Annual review of pathology (01-01-2011)“…Recent investigation into the mechanisms of Parkinson's disease (PD) has generated remarkable insight while simultaneously challenging traditional conceptual…”
Get full text
Journal Article -
13
α-Synuclein Promotes Neuronal Dysfunction and Death by Disrupting the Binding of Ankyrin to β-Spectrin
Published in The Journal of neuroscience (01-03-2023)“…α-Synuclein plays a key role in the pathogenesis of Parkinson's disease and related disorders, but critical interacting partners and molecular mechanisms…”
Get full text
Journal Article -
14
Alexander disease
Published in The Journal of neuroscience (11-04-2012)Get full text
Journal Article -
15
Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model
Published in Proceedings of the National Academy of Sciences - PNAS (29-12-2020)“…Mitochondrial and metabolic dysfunction are often implicated in neurological disease, but effective mechanism-based therapies remain elusive. We performed a…”
Get full text
Journal Article -
16
The unfolded protein response protects from tau neurotoxicity in vivo
Published in PloS one (29-09-2010)“…The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in…”
Get full text
Journal Article -
17
PARP Inhibitors and Parkinson’s Disease
Published in The New England journal of medicine (31-01-2019)“…A recent study implicates the enzyme poly(adenosine 5′-diphosphate-ribose) polymerase 1 (PARP1) as a mediator of neuronal cell death in Parkinson’s disease…”
Get full text
Journal Article -
18
α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity
Published in Human molecular genetics (15-10-2006)“…Alpha-synuclein is a neuronal protein implicated genetically in Parkinson's disease. alpha-synuclein localizes to the nucleus and presynaptic nerve terminals…”
Get full text
Journal Article -
19
Glial α‐synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo
Published in Glia (01-10-2019)“…α‐Synucleinopathies are neurodegenerative diseases that are characterized pathologically by α‐synuclein inclusions in neurons and glia. The pathologic…”
Get full text
Journal Article -
20
Elevated Oxidative Stress and DNA Damage in Cortical Neurons of Chemotherapy Patients
Published in Journal of neuropathology and experimental neurology (01-07-2021)“…Abstract The unintended neurologic sequelae of chemotherapy contribute to significant patient morbidity. Chemotherapy-related cognitive impairment (CRCI) is…”
Get full text
Journal Article