Search Results - "Fealey, Michael"

Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation by Avery, Adam W., Fealey, Michael E., Wang, Fengbin, Orlova, Albina, Thompson, Andrew R., Thomas, David D., Hays, Thomas S., Egelman, Edward H.

“…Spinocerebellar ataxia type 5 (SCA5) is a neurodegenerative disease caused by mutations in the cytoskeletal protein β-III-spectrin. Previously, a SCA5 mutation…”
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Structural Impact of Phosphorylation and Dielectric Constant Variation on Synaptotagmin’s IDR by Fealey, Michael E., Binder, Benjamin P., Uversky, Vladimir N., Hinderliter, Anne, Thomas, David D.

“…We used time-resolved Förster resonance energy transfer, circular dichroism, and molecular dynamics simulation to investigate the structural dependence of…”
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On the difficulties of characterizing weak protein interactions that are critical for neurotransmitter release by Rizo, Josep, David, Guillaume, Fealey, Michael E., Jaczynska, Klaudia

“…The mechanism of neurotransmitter release has been extensively characterized, showing that vesicle fusion is mediated by the SNARE complex formed by…”
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Dynamics of Dystrophin’s Actin-Binding Domain by Fealey, Michael E., Horn, Benjamin, Coffman, Christian, Miller, Robert, Lin, Ava Y., Thompson, Andrew R., Schramel, Justine, Groth, Erin, Hinderliter, Anne, Cembran, Alessandro, Thomas, David D.

“…We have used pulsed electron paramagnetic resonance, calorimetry, and molecular dynamics simulations to examine the structural mechanism of binding for…”
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Complications of Endovascular Polymers Associated With Vascular Introducer Sheaths and Metallic Coils in 3 Patients, With Literature Review by FEALEY, Michael E, EDWARDS, William D, GIANNINI, Caterina, PIEPGRAS, David G, CLOFT, Harry, RIHAL, Charanjit S

“…Hydrophilic coatings on arterial introducer sheaths reduce the frequency of spasm during cardiac catheterization. Moreover, during treatment of cerebral artery…”
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Negative coupling as a mechanism for signal propagation between C2 domains of synaptotagmin I by Fealey, Michael E, Gauer, Jacob W, Kempka, Sarah C, Miller, Katie, Nayak, Kamakshi, Sutton, R Bryan, Hinderliter, Anne

“…Synaptotagmin I (Syt I) is a vesicle-localized protein implicated in sensing the calcium influx that triggers fast synchronous release of neurotransmitter. How…”
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Synaptotagmin I’s Intrinsically Disordered Region Interacts with Synaptic Vesicle Lipids and Exerts Allosteric Control over C2A by Fealey, Michael E, Mahling, Ryan, Rice, Anne M, Dunleavy, Katie, Kobany, Stephanie E. G, Lohese, K. Jean, Horn, Benjamin, Hinderliter, Anne

“…Synaptotagmin I (Syt I) is a vesicle-localized integral membrane protein that senses the calcium ion (Ca2+) influx to trigger fast synchronous release of…”
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Enhanced synaptotagmin plasticity derived from pairing intrinsic disorder with synaptic vesicle lipids by Fealey, Michael E., Thomas, David D., Hinderliter, Anne

“…Synaptotagmin 1 (Syt 1) is an integral membrane protein responsible for sensing the calcium ion (Ca 2+ ) influx in neurons that triggers synaptic vesicle…”
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MGMT promoter methylation and immunoexpression in aggressive pituitary adenomas and carcinomas by Salehi, Fateme, Scheithauer, Bernd W., Kros, Johann M., Lau, Queenie, Fealey, Michael, Erickson, Dana, Kovacs, Kalman, Horvath, Eva, Lloyd, Ricardo V.

“…MGMT promoter hypermethylation of aggressive pituitary adenomas and pituitary carcinomas and low protein expression are implicated in improved response to…”
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Randomly organized lipids and marginally stable proteins: A coupling of weak interactions to optimize membrane signaling by Rice, Anne M., Mahling, Ryan, Fealey, Michael E., Rannikko, Anika, Dunleavy, Katie, Hendrickson, Troy, Lohese, K. Jean, Kruggel, Spencer, Heiling, Hillary, Harren, Daniel, Sutton, R. Bryan, Pastor, John, Hinderliter, Anne

“…Eukaryotic lipids in a bilayer are dominated by weak cooperative interactions. These interactions impart highly dynamic and pliable properties to the membrane…”
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Allostery and instability in the functional plasticity of synaptotagmin I by Fealey, Michael E., Hinderliter, Anne

“…Synaptotagmin I (Syt I) is the calcium ion sensor for regulated release of neurotransmitter. How Syt I mediates this cellular event has been a question of…”
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Unicommissural aortic valves: gross, histological, and immunohistochemical analysis of 52 cases (1978-2008) by Fealey, Michael E, Edwards, William D, Miller, Dylan V, Maleszewski, Joseph J

“…Abstract Background Unicommissural aortic valves (UAVs) are rare anomalies in which adjacent cusps of two commissures are congenitally fused. Currently,…”
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MGMT Immunoexpression in Silent Subtype 3 Pituitary Adenomas: Possible Therapeutic Implications by Fealey, Michael E, Scheithauer, Bernd W, Horvath, Eva, Erickson, Dana, Kovacs, Kalman, McLendon, Roger, Lloyd, Ricardo V

“…The objective of the study was to assess O ⁶-methylguanine-DNA methyltransferase (MGMT) immunoreactivity in pituitary adenomas of silent subtype 3 as a…”
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Prosthetic valve endocarditis: clinicopathological correlates in 122 surgical specimens from 116 patients (1985–2004) by Lee, Jonathan H, Burner, Kimberly D, Fealey, Michael E, Edwards, William D, Tazelaar, Henry D, Orszulak, Thomas A, Wright, Alan J, Baddour, Larry M

“…Abstract Background Few studies have documented the clinicopathological features of prosthetic valve endocarditis independently of native valve endocarditis…”
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Recurrent cardiac calcific amorphous tumor: the CAT had a kitten by Fealey, Michael E, Edwards, William D, Reynolds, Carol A, Pellikka, Patricia A, Dearani, Joseph A

“…Abstract Background Cardiac calcified amorphous tumors (CATs) represent degenerating intracavitary mural thrombi that can mimic neoplasms and cause symptoms…”
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Hamartomas of mature cardiac myocytes: report of 7 new cases and review of literature by Fealey, Michael E, Edwards, William D., MD, Miller, Dylan V., MD, Menon, Shaji C., MD, Dearani, Joseph A., MD

“…Summary Only 8 cases of hamartomas of mature cardiac myocytes have been reported. The aim of the study was to describe 7 new cases and provide…”
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Neuronal ceroid lipofuscinosis in a 31-year-old woman presenting as biventricular heart failure with restrictive features by Fealey, Michael E, Edwards, William D, Grogan, Martha, Orszulak, Thomas A

“…Abstract A 31-year-old woman presented with dyspnea and left-sided chest discomfort and was found to have biventricular heart failure with impaired ventricular…”
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Echocardiographic features of cardiac amyloidosis presenting as endomyocardial disease in a 54-year-old male by Fealey, Michael E, Edwards, William D., MD, Buadi, Francis K., MD, Syed, Imran S., MD, Grogan, Martha, MD

“…Summary Although primary cardiac amyloidosis is a rare affliction of the heart, its clinical and pathology features have been well described. Patients…”
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Primary cardiac amyloidosis with 20-year survival by Fealey, Michael E., Edwards, William D., Grogan, Martha, Dispenzieri, Angela

“…The natural history of primary amyloidosis is poor, and for patients with symptomatic cardiac involvement, survival is generally less than 6 months. Even among…”
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Congenital aortic sinus aneurysm causing sudden unexpected death in a 56-year-old woman by Fealey, Michael E, Edwards, William D, McMaster, 3rd, Kitt R, Carter, John B

“…Sudden unexpected death due to hemopericardium generally has 2 main causes, rupture of the ascending aorta or rupture of a transmural myocardial infarct. We…”
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