Search Results - "Feaga, Heather A"

Transcription regulates ribosome hibernation by Feaga, Heather A., Dworkin, Jonathan

“…Most bacteria are quiescent, typically as a result of nutrient limitation. In order to minimize energy consumption during this potentially prolonged state,…”
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Ribosome Dimerization Protects the Small Subunit by Feaga, Heather A, Kopylov, Mykhailo, Kim, Jenny Kim, Jovanovic, Marko, Dworkin, Jonathan

“…When nutrients become scarce, bacteria can enter an extended state of quiescence. A major challenge of this state is how to preserve ribosomes for the return…”
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Resolving nonstop translation complexes is a matter of life or death by Keiler, Kenneth C, Feaga, Heather A

“…Problems during gene expression can result in a ribosome that has translated to the 3' end of an mRNA without terminating at a stop codon, forming a nonstop…”
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Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA by Dillon, Nicholas A., Peterson, Nicholas D., Feaga, Heather A., Keiler, Kenneth C., Baughn, Anthony D.

“…Pyrazinamide (PZA) is a first line anti-tubercular drug for which the mechanism of action remains unresolved. Recently, it was proposed that the active form of…”
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Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria by Feaga, Heather A, Quickel, Michael D, Hankey-Giblin, Pamela A, Keiler, Kenneth C

“…Bacteria use trans-translation and the alternative rescue factors ArfA (P36675) and ArfB (Q9A8Y3) to hydrolyze peptidyl-tRNA on ribosomes that stall near the…”
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Release of nonstop ribosomes is essential by Feaga, Heather A, Viollier, Patrick H, Keiler, Kenneth C

“…Bacterial ribosomes frequently translate to the 3' end of an mRNA without terminating at a stop codon. Almost all bacteria use the transfer-messenger RNA…”
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Host Specificity of Ovine Bordetella parapertussis and the Role of Complement by Hester, Sara E, Goodfield, Laura L, Park, Jihye, Feaga, Heather A, Ivanov, Yury V, Bendor, Liron, Taylor, Dawn L, Harvill, Eric T

“…The classical bordetellae are comprised of three subspecies that differ from broad to very limited host specificity. Although several lineages appear to have…”
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Horizontally acquired divergent O-antigen contributes to escape from cross-immunity in the classical bordetellae by Hester, Sara E, Park, Jihye, Goodfield, Laura L, Feaga, Heather A, Preston, Andrew, Harvill, Eric T

“…Horizontal gene transfer (HGT) allows for rapid spread of genetic material between species, increasing genetic and phenotypic diversity. Although HGT…”
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A Wolf in Sheep’s Clothing: Chromosomal Pathogenicity Islands Co-opt Phage Capsids to Facilitate Horizontal Spread by Feaga, Heather A., Dworkin, Jonathan

“…Fillol-Salom et al. describe a mechanism by which an Escherichia coli pathogenicity island is preferentially packaged into a phage particle, thus promoting the…”
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The ribosome-associated quality control pathway supports survival in the absence of non-stop ribosome rescue factors by Callan, Katrina, Prince, Cassidy R., Feaga, Heather A.

“…In bacteria, if a ribosome translates an mRNA lacking a stop codon it becomes stalled at the 3′ end of the message. These ribosomes must be rescued by…”
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Elongation Factor P Is Important for Sporulation Initiation by Feaga, Heather A, Hong, Hye-Rim, Prince, Cassidy R, Rankin, Ananda, Buskirk, Allen R, Dworkin, Jonathan

“…The universally conserved protein elongation factor P (EF-P) facilitates translation at amino acids that form peptide bonds with low efficiency, particularly…”
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YfmR is a translation factor that prevents ribosome stalling and cell death in the absence of EF-P by Hong, Hye-Rim, Prince, Cassidy R, Tetreault, Daniel D, Wu, Letian, Feaga, Heather A

“…Protein synthesis is performed by the ribosome and a host of highly conserved elongation factors. Elongation factor P (EF-P) prevents ribosome stalling at…”
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Clickable methionine as a universal probe for labelling intracellular bacteria by Atwal, Sharanjeet, Giengkam, Suparat, Jaiyen, Yanin, Feaga, Heather A., Dworkin, Jonathan, Salje, Jeanne

“…Despite their clinical and biological importance, the cell biology of obligate intracellular bacteria is less well understood than that of many free-living…”
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Affinity of Cu+ for the Copper-Binding Domain of the Amyloid-β Peptide of Alzheimer’s Disease by Feaga, Heather A, Maduka, Richard C, Foster, Monique N, Szalai, Veronika A

“…The role of metal ions in Alzheimer’s disease etiology is unresolved. For the redox-active metal ions iron and copper, the formation of reactive oxygen species…”
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Resident Microbiota Affect Bordetella pertussis Infectious Dose and Host Specificity by Weyrich, Laura S., Feaga, Heather A., Park, Jihye, Muse, Sarah J., Safi, Chetan Y., Rolin, Olivier Y., Young, Sarah E., Harvill, Eric T.

“…Before contacting host tissues, invading pathogens directly or indirectly interact with host microbiota, but the effects of such interactions on the initial…”
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Ribosome Rescue is Essential in Bacteria and Human Cells by Feaga, Heather A

“…All life on earth relies on the ability to translate the genetic code into protein. DNA is transcribed first into mRNA, which is then decoded by the ribosome…”
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Host Specificity of Ovine Bordetella parapertussis and the Role of Complement: e0130964 by Hester, Sara E, Goodfield, Laura L, Park, Jihye, Feaga, Heather A, Ivanov, Yury V, Bendor, Liron, Taylor, Dawn L, Harvill, Eric T

“…The classical bordetellae are comprised of three subspecies that differ from broad to very limited host specificity. Although several lineages appear to have…”
Get full text