Search Results - "Fazzone, William"

DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines by LaBonte, Melissa J, Wilson, Peter M, Fazzone, William, Groshen, Susan, Lenz, Heinz-Josef, Ladner, Robert D

“…Despite the significant progress made in colon cancer chemotherapy, advanced disease remains largely incurable and novel efficacious chemotherapies are…”
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Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage by Wilson, Peter M, Fazzone, William, LaBonte, Melissa J, Lenz, Heinz-Josef, Ladner, Robert D

“…Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) catalyzes the hydrolysis of dUTP to dUMP and PPi. Although dUTP is a normal intermediate in DNA…”
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Novel opportunities for thymidylate metabolism as a therapeutic target by Wilson, Peter M, Fazzone, William, LaBonte, Melissa J, Deng, Jinxia, Neamati, Nouri, Ladner, Robert D

“…For over 40 years, the fluoropyrimidine 5-fluorouracil (5-FU) has remained the central agent in therapeutic regimens employed in the treatment of colorectal…”
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Association of Methylenetetrahydrofolate Reductase Gene Polymorphisms and Sex-Specific Survival in Patients With Metastatic Colon Cancer by WU ZHANG, PRESS, Oliver A, LENZ, Heinz-Josef, HAIMAN, Christopher A, DONG YUN YANG, GORDON, Michael A, FAZZONE, William, EL-KHOUEIRY, Anthony, IQBAL, Syma, SHERROD, Andy E, LURJE, Georg

“…Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating intracellular folate levels, which affects DNA synthesis and methylation. Two MTHFR gene…”
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Molecular determinants of irinotecan efficacy by Vallböhmer, Daniel, Iqbal, Syma, Yang, Dong Yun, Rhodes, Katrin E., Zhang, Wu, Gordon, Michael, Fazzone, William, Schultheis, Anne M., Sherrod, Andy E., Danenberg, Kathleen D., Lenz, Heinz‐Josef

“…Molecular markers predicting the efficacy of CPT‐11 based chemotherapies in patients with colorectal cancer (CRC) are unknown. Therefore, we investigated…”
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Understanding US healthcare provider preferences for consumption of publication content: opportunities to leverage omnichannel approaches by Bessler, Jessica B, Fazzone, William, Sladicka, Nancy, Ruth, Adam

“…Understanding the healthcare provider (HCP) journey of discovering and consuming medical and scientific information is critical for optimizing publication…”
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Histone deacetylase inhibitors suppress thymidylate synthase gene expression and synergize with the fluoropyrimidines in colon cancer cells by Fazzone, William, Wilson, Peter M., LaBonte, Melissa J., Lenz, Heinz‐Josef, Ladner, Robert D.

“…Despite recent therapeutic advances, the response rates to chemotherapy for patients with metastatic colon cancer remain at ∼50% with the fluoropyrimidine,…”
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Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab by Zhang, Wu, Gordon, Michael, Press, Oliver A, Rhodes, Katrin, Vallböhmer, Daniel, Yang, Dong Yun, Park, David, Fazzone, William, Schultheis, Anne, Sherrod, Andy E, Iqbal, Syma, Groshen, Susan, Lenz, Heinz-Josef

“…The study aimed to investigate whether polymorphisms in genes of the EGFR signaling pathway are associated with clinical outcome in advanced colorectal cancer…”
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phase I/II trial of vorinostat in combination with 5-fluorouracil in patients with metastatic colorectal cancer who previously failed 5-FU-based chemotherapy by Wilson, Peter M, El-Khoueiry, Anthony, Iqbal, Syma, Fazzone, William, LaBonte, Melissa J, Groshen, Susan, Yang, Dongyun, Danenberg, Kathy D, Cole, Sarah, Kornacki, Margaret, Ladner, Robert D, Lenz, Heinz-Josef

“…Purpose We conducted a phase I/II clinical trial to determine the safety and feasibility of combining vorinostat with 5-fluorouracil (5-FU) in patients with…”
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Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer by Lurje, Georg, Zhang, Wu, Yang, Dongyun, Groshen, Susan, Hendifar, Andrew E, Husain, Hatim, Nagashima, Fumio, Chang, Heung M, Fazzone, William, Ladner, Robert D, Pohl, Alexandra, Ning, Yan, Iqbal, Syma, El-Khoueiry, Anthony, Lenz, Heinz-Josef

“…BACKGROUNDTumor recurrence after curative resection is a major problem in the management of colon cancer therapy. Identifying molecular markers for tumor…”
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Identification of sequence determinants of human nuclear dUTPase isoform localization by Tinkelenberg, Beverly A, Fazzone, William, Lynch, Frank J, Ladner, Robert D

“…dUTP nucleotidohydrolase (dUTPase) catalyzes the hydrolysis of dUTP to dUMP and pyrophosphate and is the central regulator of cellular dUTP pools. Nuclear…”
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ABCB1, SLCO1B1 and UGT1A1 gene polymorphisms are associated with toxicity in metastatic colorectal cancer patients treated with first-line irinotecan by Rhodes, Katrin E, Zhang, Wu, Yang, Dongyun, Press, Oliver A, Gordon, Michael, Vallböhmer, Daniel, Schultheis, Anne M, Lurje, Georg, Ladner, Robert D, Fazzone, William, Iqbal, Syma, Lenz, Heinz-Josef

“…We tested specific gene polymorphisms known to be involved in the irinotecan (CPT-11) metabolic pathway. The combination of at least one SLCO1B1 521 T allele,…”
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