The mechanoreceptor pezo-1 is required for normal crawling locomotion in the nematode C. elegans
The discovery in 2010 of the PIEZO family of mechanoreceptors revolutionized our understanding of the role of proprioceptive feedback in mammalian physiology. Much remains to be elucidated. This study looks at the role this receptor plays in normal locomotion. Like humans, the nematode expresses PIE...
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| Published in: | microPublication biology Vol. 2023 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Caltech Library
2023
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | The discovery in 2010 of the PIEZO family of mechanoreceptors revolutionized our understanding of the role of proprioceptive feedback in mammalian physiology. Much remains to be elucidated. This study looks at the role this receptor plays in normal locomotion. Like humans, the nematode
expresses PIEZO-type channels (encoded by the
gene) throughout its somatic musculature. Here we use the unbiased automated behavioral software Tierpsy to characterize the effects that mutations removing PEZO-1 from body wall musculature have on
crawling. We find that loss of PEZO-1 results in disrupted locomotion and posture, consistent with phenotypes associated with loss of PIEZO2 in human musculature.
is thus an amenable system to study the role of mechanoreception on muscle physiology and function. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 The authors declare that there are no conflicts of interest present. |
| ISSN: | 2578-9430 2578-9430 |
| DOI: | 10.17912/micropub.biology.001085 |