Investigating Immunomodulatory Biomaterials for Preventing the Foreign Body Response

Investigating Immunomodulatory Biomaterials for Preventing the Foreign Body Response

Implantable biomaterials represent the forefront of regenerative medicine, providing platforms and vessels for delivering a creative range of therapeutic benefits in diverse disease contexts. However, the chronic damage resulting from implant rejection tends to outweigh the intended healing benefits...

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Bibliographic Details
Published in:Bioengineering (Basel) Vol. 10; no. 12; p. 1411
Main Authors: Kim, Alexia, Downer, Mauricio A, Berry, Charlotte E, Valencia, Caleb, Fazilat, Alex Z, Griffin, Michelle
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-12-2023
Subjects:
Adsorption
Angiogenesis
Biocompatibility
Bioengineering
Biomaterials
Biomedical materials
Blood vessels
Cell interactions
Cytokines
Extracellular matrix
Fibroblasts
Fibrosis
Foreign bodies
Foreign bodies (Medical care)
foreign body response
Growth factors
Healing
Health aspects
Immune response
Immune system
Immunity
Immunomodulation
Inflammation
Macrophages
Material properties
Medical equipment
Medical research
Microenvironments
Neutrophils
Polyvinyl alcohol
Prevention
Regenerative medicine
Rejection
Silicones
Surface chemistry
Surgical implants
Tissue engineering
Transplants & implants
Tumor necrosis factor-TNF
Wound healing
United States
immunomodulation
macrophages
foreign body response
biomaterials
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Summary:Implantable biomaterials represent the forefront of regenerative medicine, providing platforms and vessels for delivering a creative range of therapeutic benefits in diverse disease contexts. However, the chronic damage resulting from implant rejection tends to outweigh the intended healing benefits, presenting a considerable challenge when implementing treatment-based biomaterials. In response to implant rejection, proinflammatory macrophages and activated fibroblasts contribute to a synergistically destructive process of uncontrolled inflammation and excessive fibrosis. Understanding the complex biomaterial-host cell interactions that occur within the tissue microenvironment is crucial for the development of therapeutic biomaterials that promote tissue integration and minimize the foreign body response. Recent modifications of specific material properties enhance the immunomodulatory capabilities of the biomaterial and actively aid in taming the immune response by tuning interactions with the surrounding microenvironment either directly or indirectly. By incorporating modifications that amplify anti-inflammatory and pro-regenerative mechanisms, biomaterials can be optimized to maximize their healing benefits in harmony with the host immune system.
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ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering10121411