Search Results - "Fawcett, James W."

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function by Fawcett, James W., Oohashi, Toshitaka, Pizzorusso, Tommaso

“…Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan (CSPG)-containing structures that surround the soma and dendrites of…”
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The extracellular matrix in plasticity and regeneration after CNS injury and neurodegenerative disease by Fawcett, James W

“…Chondroitin sulfate proteoglycans (CSPGs) are involved in several processes relevant to recovery of function after CNS damage. They restrict axon regeneration…”
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Intrinsic Determinants of Axon Regeneration by Fawcett, James W., Verhaagen, Joost

“…The failure of axons to regenerate in the damaged mammalian CNS is the main impediment to functional recovery. There are many molecules and structures in the…”
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Assembly of a new growth cone after axotomy: the precursor to axon regeneration by Bradke, Frank, Fawcett, James W., Spira, Micha E.

“…Key Points Before a cut axon can attempt to grow, it first has to assemble a new growth cone at its tip. The mechanism leading to the assembly of a new growth…”
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Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity by Sorg, Barbara A, Berretta, Sabina, Blacktop, Jordan M, Fawcett, James W, Kitagawa, Hiroshi, Kwok, Jessica C F, Miquel, Marta

“…Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in…”
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Optimization of adeno-associated viral vector-mediated transduction of the corticospinal tract: comparison of four promoters by Nieuwenhuis, Bart, Haenzi, Barbara, Hilton, Sam, Carnicer-Lombarte, Alejandro, Hobo, Barbara, Verhaagen, Joost, Fawcett, James W.

“…Adeno-associated viral vectors are widely used as vehicles for gene transfer to the nervous system. The promoter and viral vector serotype are two key factors…”
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The extracellular matrix and perineuronal nets in memory by Fawcett, James W., Fyhn, Marianne, Jendelova, Pavla, Kwok, Jessica C. F., Ruzicka, Jiri, Sorg, Barbara A.

“…All components of the CNS are surrounded by a diffuse extracellular matrix (ECM) containing chondroitin sulphate proteoglycans (CSPGs), heparan sulphate…”
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Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity by Rowlands, Daire, Lensjø, Kristian K, Dinh, Tovy, Yang, Sujeong, Andrews, Melissa R, Hafting, Torkel, Fyhn, Marianne, Fawcett, James W, Dick, Gunnar

“…In the adult brain, the extracellular matrix (ECM) influences recovery after injury, susceptibility to mental disorders, and is in general a strong regulator…”
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Integrins promote axonal regeneration after injury of the nervous system by Nieuwenhuis, Bart, Haenzi, Barbara, Andrews, Melissa R., Verhaagen, Joost, Fawcett, James W.

“…ABSTRACT Integrins are cell surface receptors that form the link between extracellular matrix molecules of the cell environment and internal cell signalling…”
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Extracellular matrix and perineuronal nets in CNS repair by Kwok, Jessica C.F., Dick, Gunnar, Wang, Difei, Fawcett, James W.

“…A perineuronal net (PNN) is a layer of lattice‐like matrix which enwraps the surface of the soma and dendrites, and in some cases the axon initial segments, in…”
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The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system by Moshayedi, Pouria, Ng, Gilbert, Kwok, Jessica C.F, Yeo, Giles S.H, Bryant, Clare E, Fawcett, James W, Franze, Kristian, Guck, Jochen

“…Abstract Devices implanted into the body become encapsulated due to a foreign body reaction. In the central nervous system (CNS), this can lead to loss of…”
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Perisynaptic chondroitin sulfate proteoglycans restrict structural plasticity in an integrin-dependent manner by Orlando, Clara, Ster, Jeanne, Gerber, Urs, Fawcett, James W, Raineteau, Olivier

“…During early postnatal development of the CNS, neuronal networks are configured through the formation, elimination, and remodeling of dendritic spines, the…”
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Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury by Petrova, Veselina, Nieuwenhuis, Bart, Fawcett, James W, Eva, Richard

“…Investigating the molecular mechanisms governing developmental axon growth has been a useful approach for identifying new strategies for boosting axon…”
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Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts by Dulin, Jennifer N., Adler, Andrew F., Kumamaru, Hiromi, Poplawski, Gunnar H. D., Lee-Kubli, Corinne, Strobl, Hans, Gibbs, Daniel, Kadoya, Ken, Fawcett, James W., Lu, Paul, Tuszynski, Mark H.

“…Neural progenitor cell (NPC) transplantation has high therapeutic potential in neurological disorders. Functional restoration may depend on the formation of…”
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Animals lacking link protein have attenuated perineuronal nets and persistent plasticity by Carulli, Daniela, Pizzorusso, Tommaso, Kwok, Jessica C. F., Putignano, Elena, Poli, Andrea, Forostyak, Serhiy, Andrews, Melissa R., Deepa, Sathyaseelan S., Glant, Tibor T., Fawcett, James W.

“…Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult central nervous system and their digestion with chondroitinase…”
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Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs by Zivraj, Krishna H, Tung, Yi Chun Loraine, Piper, Michael, Gumy, Laura, Fawcett, James W, Yeo, Giles S H, Holt, Christine E

“…Cue-directed axon guidance depends partly on local translation in growth cones. Many mRNA transcripts are known to reside in developing axons, yet little is…”
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Overcoming inhibition in the damaged spinal cord by Fawcett, James W

“…Inhibition by several inhibitory molecules on oligodendrocytes, and by chondroitin sulphate proteoglycans and semaphorins in the glial scar discourages…”
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Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury by Rosenzweig, Ephron S., Salegio, Ernesto A., Liang, Justine J., Weber, Janet L., Weinholtz, Chase A., Brock, John H., Moseanko, Rod, Hawbecker, Stephanie, Pender, Roger, Cruzen, Christina L., Iaci, Jennifer F., Caggiano, Anthony O., Blight, Andrew R., Haenzi, Barbara, Huie, J. Russell, Havton, Leif A., Nout-Lomas, Yvette S., Fawcett, James W., Ferguson, Adam R., Beattie, Michael S., Bresnahan, Jacqueline C., Tuszynski, Mark H.

“…Inhibitory extracellular matrices form around mature neurons as perineuronal nets containing chondroitin sulfate proteoglycans that limit axonal sprouting…”
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Proteoglycan Sulphation in the Function of the Mature Central Nervous System by Fawcett, James W, Kwok, Jessica C F

“…Chondroitin sulphate and heparan sulphate proteoglycans (CSPGS and HSPGs) are found throughout the central nervous system (CNS). CSPGs are ubiquitous in the…”
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Depletion of perineuronal nets enhances recognition memory and long-term depression in the perirhinal cortex by Romberg, Carola, Yang, Sujeong, Melani, Riccardo, Andrews, Melissa R, Horner, Alexa E, Spillantini, Maria G, Bussey, Timothy J, Fawcett, James W, Pizzorusso, Tommaso, Saksida, Lisa M

“…Perineuronal nets (PNNs) are extracellular matrix structures surrounding cortical neuronal cell bodies and proximal dendrites and are involved in the control…”
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