Search Results - "Favagrossa, Monica"

Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington’s disease by Birolini, Giulia, Valenza, Marta, Ottonelli, Ilaria, Talpo, Francesca, Minoli, Lucia, Cappelleri, Andrea, Bombaci, Mauro, Caccia, Claudio, Canevari, Caterina, Trucco, Arianna, Leoni, Valerio, Passoni, Alice, Favagrossa, Monica, Nucera, Maria Rosaria, Colombo, Laura, Paltrinieri, Saverio, Bagnati, Renzo, Duskey, Jason Thomas, Caraffi, Riccardo, Vandelli, Maria Angela, Taroni, Franco, Salmona, Mario, Scanziani, Eugenio, Biella, Gerardo, Ruozi, Barbara, Tosi, Giovanni, Cattaneo, Elena

“…Evidence that Huntington's disease (HD) is characterized by impaired cholesterol biosynthesis in the brain has led to strategies to increase its level in the…”
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A cutting-edge approach based on UHPLC-MS to simultaneously investigate oxysterols and cholesterol precursors in biological samples: Validation in Huntington's disease mouse model by Passoni, Alice, Favagrossa, Monica, Valenza, Marta, Birolini, Giulia, Lanno, Alessia, Mariotti, Caterina, Cattaneo, Elena, Salmona, Mario, Colombo, Laura, Bagnati, Renzo

“…•Reduced cholesterol biosynthesis in the brain is an early dysfunction in Huntington's disease.•Liquid chromatography-mass spectrometry is a powerful technique…”
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Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles for cholesterol delivery in Huntington's disease by Birolini, Giulia, Valenza, Marta, Ottonelli, Ilaria, Passoni, Alice, Favagrossa, Monica, Duskey, Jason T., Bombaci, Mauro, Vandelli, Maria Angela, Colombo, Laura, Bagnati, Renzo, Caccia, Claudio, Leoni, Valerio, Taroni, Franco, Forni, Flavio, Ruozi, Barbara, Salmona, Mario, Tosi, Giovanni, Cattaneo, Elena

“…Supplementing brain cholesterol is emerging as a potential treatment for Huntington's disease (HD), a genetic neurodegenerative disorder characterized, among…”
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A novel bio-inspired strategy to prevent amyloidogenesis and synaptic damage in Alzheimer’s disease by Catania, Marcella, Colombo, Laura, Sorrentino, Stefano, Cagnotto, Alfredo, Lucchetti, Jacopo, Barbagallo, Maria Chiara, Vannetiello, Ilaria, Vecchi, Elena Rita, Favagrossa, Monica, Costanza, Massimo, Giaccone, Giorgio, Salmona, Mario, Tagliavini, Fabrizio, Di Fede, Giuseppe

“…Alzheimer’s disease (AD) is an irreversible neurodegenerative disorder that affects millions of people worldwide. AD pathogenesis is intricate. It primarily…”
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I07 A new generation of brain-targeted nanoparticles for cholesterol delivery in huntington’s disease: kinetics, drug release and behavioral effects in mouse models by Valenza, Marta, Birolini, Giulia, Ottonelli, Ilaria, Passoni, Alice, Favagrossa, Monica, Duskey, Jason T, Bombaci, Mauro, Ruozi, Barbara, Salmona, Mario, Tosi, Giovanni, Cattaneo, Elena

“…BackgroundCholesterol (Chol), an essential molecule for brain function, is produced locally in the brain as the blood-brain barrier (BBB) prevents its uptake…”
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D14 Plasma levels of 24S-hydroxycholesterol are reduced in Huntington disease subjects: preliminary results of a 2-year longitudinal study by Fichera, Mario, Nanetti, Lorenzo, Favagrossa, Monica, Castaldo, Anna, Nigri, Anna, Mongelli, Alessia, Marchini, Gloria, Gellera, Cinzia, Grisoli, Marina, Birolini, Giulia, Valenza, Marta, Bagnati, Renzo, Passoni, Alice, Colombo, Laura, Cattaneo, Elena, Salmona, Mario, Mariotti, Caterina

“…ObjectivesBrain cholesterol is produced in situ and its turn-over is ensured by the conversion into 24S-hydroxycholesterol (24-OHC) which can cross the…”
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I17 Sustained benefits of brain-permeable cholesterol-loaded nanoparticles in zQ175DN mouse model by Valenza, Marta, Birolini, Giulia, Ottonelli, Ilaria, Talpo, Francesca, Passoni, Alice, Favagrossa, Monica, Colombo, Laura, Caraffi, Riccardo, Caccia, Claudio, Leoni, Valerio, Taroni, Franco, Cappelleri, Andrea, Minoli, Lucia, Paltrinieri, Saverio, Scanziani, Eugenio, Ruozi, Barbara, Salmona, Mario, Biella, Gerardo, Tosi, Giovanni, Cattaneo, Elena

“…BackgroundHuntington’s disease (HD) is associated with reduced synthesis of brain cholesterol (chol) and mounting evidence highlights the concept that…”
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Efficacy of Cholesterol Nose-to-Brain Delivery for Brain Targeting in Huntington’s Disease by Passoni, Alice, Favagrossa, Monica, Colombo, Laura, Bagnati, Renzo, Gobbi, Marco, Diomede, Luisa, Birolini, Giulia, Di Paolo, Eleonora, Valenza, Marta, Cattaneo, Elena, Salmona, Mario

“…The current pharmacological treatment of Huntington’s disease (HD) is palliative, and therapies to restore functions in patients are needed. One of the…”
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