Search Results - "Fauty, Scott E."

Physicochemical properties, form, and formulation selection strategy for a biopharmaceutical classification system class II preclinical drug candidate by Lohani, Sachin, Cooper, Harriet, Jin, Xiaoling, Nissley, Becky P, Manser, Kimberly, Rakes, Linda Huong, Cummings, John J, Fauty, Scott E, Bak, Annette

“…This work summarizes the pharmaceutical evaluation of a preclinical drug candidate with poor physicochemical properties. Compound 1 is a weakly basic, GPR-119…”
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Combined Use of Crystalline Sodium Salt and Polymeric Precipitation Inhibitors to Improve Pharmacokinetic Profile of Ibuprofen through Supersaturation by Terebetski, Jenna L., Cummings, John J., Fauty, Scott E., Michniak-Kohn, Bozena

“…To maximize the pharmacological effect of a pain reliever such as ibuprofen, early onset of action is critical. Unfortunately, the acidic nature of ibuprofen…”
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Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat P-glycoproteins mdr1a/1b and cytochrome P450 3A1/2 by Mei, Qin, Richards, Karen, Strong-Basalyga, Kristie, Fauty, Scott E, Taylor, Anne, Yamazaki, Masayo, Prueksaritanont, Thomayant, Lin, Jiunn H, Hochman, Jerome

“…Cytochromes P450 (CYPs) and p-glycoproteins (Pgps) are believed to play important roles in drug absorption, metabolism, and elimination. Numerous drugs and…”
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Administration of Fenofibrate Markedly Elevates Fabp3 in Rat Liver and Plasma and Confounds Its Use as a Preclinical Biomarker of Cardiac and Muscle Toxicity by Kochansky, Christopher J., Lyman, Michael J., Fauty, Scott E., Vlasakova, Katerina, D'mello, Anil P.

“…Proteins involved in lipid homeostasis are often regulated through the nuclear peroxisome proliferator‐activated receptors (PPAR). PPARα is the target for the…”
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siRNA-Mediated Knockdown of P450 Oxidoreductase in Rats: A Tool to Reduce Metabolism by CYPs and Increase Exposure of High Clearance Compounds by Burke, Rob S., Somasuntharam, Inthirai, Rearden, Paul, Brown, Duncan, Deshmukh, Sujal V., DiPietro, Martha A., DiMuzio, Jillian, Eisenhandler, Roy, Fauty, Scott E., Gibson, Christopher, Gindy, Marian E., Hamilton, Kelly A., Knemeyer, Ian, Koeplinger, Kenneth A., Kwon, Hae Won, Lifsted, Traci Q., Menzel, Karsten, Patel, Mihir, Pudvah, Nicole, Rudd, Deanne Jackson, Seitzer, Jessica, Strapps, Walter R., Prueksaritanont, Thomayant, Thompson, Charles D., Hochman, Jerome H., Carr, Brian A.

“…ABSTRACT Purpose To develop a tool based on siRNA-mediated knockdown of hepatic P450 oxidoreductase (POR) to decrease the CYP-mediated metabolism of small…”
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