Search Results - "Faustino, Paula"

An overview of molecular basis of iron metabolism regulation and the associated pathologies by Silva, Bruno, Faustino, Paula

“…Iron is essential for several vital biological processes. Its deficiency or overload drives to the development of several pathologies. To maintain iron…”
Get full text

From Stress to Sick(le) and Back Again–Oxidative/Antioxidant Mechanisms, Genetic Modulation, and Cerebrovascular Disease in Children with Sickle Cell Anemia by Silva, Marisa, Faustino, Paula

“…Sickle cell anemia (SCA) is a genetic disease caused by the homozygosity of the HBB:c.20A>T mutation, which results in the production of hemoglobin S (HbS). In…”
Get full text

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia by Mettananda, Sachith, Fisher, Chris A., Hay, Deborah, Badat, Mohsin, Quek, Lynn, Clark, Kevin, Hublitz, Philip, Downes, Damien, Kerry, Jon, Gosden, Matthew, Telenius, Jelena, Sloane-Stanley, Jackie A., Faustino, Paula, Coelho, Andreia, Doondeea, Jessica, Usukhbayar, Batchimeg, Sopp, Paul, Sharpe, Jacqueline A., Hughes, Jim R., Vyas, Paresh, Gibbons, Richard J., Higgs, Douglas R.

“…β-Thalassemia is one of the most common inherited anemias, with no effective cure for most patients. The pathophysiology reflects an imbalance between α- and…”
Get full text

The role of ICT in enhancing the autonomy of higher education students: Teachers’ insights by Dora Simões, Paula Faustino

“…This article reflects on the insights of higher education teachers about the role that information and communication technologies (ICT) can have in enhancing…”
Get full text

Prevalence Rate of Thalassemia Carriers among Individuals with Microcytosis or Hypochromia in Portugal by Santos, Daniela, Barreto, Marta, Kislaya, Irina, Mendonça, Joana, P Machado, Miguel, Lopes, Pedro, Matias Dias, Carlos, Faustino, Paula

“…Microcytosis and hypochromia result from deficient hemoglobin synthesis in red blood cells and are easily detected in a complete blood count test. These…”
Get full text

Evaluation of an RBD-nucleocapsid fusion protein as a booster candidate for COVID-19 vaccine by Valiate, Bruno Vinicius Santos, Castro, Julia Teixeira de, Marçal, Tomás Gazzinelli, Andrade, Luis Adan Flores, Oliveira, Livia Isabela de, Maia, Gabriela Barbi Freire, Faustino, Lídia Paula, Hojo-Souza, Natalia S., Reis, Marconi Augusto Aguiar Dos, Bagno, Flávia Fonseca, Salazar, Natalia, Teixeira, Santuza R., Almeida, Gregório Guilherme, Gazzinelli, Ricardo Tostes

“…Despite successful vaccines and updates, constant mutations of SARS-CoV-2 makes necessary the search for new vaccines. We generated a chimeric protein that…”
Get full text

Differential HFE gene expression is regulated by alternative splicing in human tissues by Martins, Rute, Silva, Bruno, Proença, Daniela, Faustino, Paula

“…The pathophysiology of HFE-derived Hereditary Hemochromatosis and the function of HFE protein in iron homeostasis remain uncertain. Also, the role of…”
Get full text

Heterobimetallic Ru()/Fe() complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets by Guedes, Adriana Pereira Mundim, Mello-Andrade, Francyelli, Pires, Wanessa Carvalho, de Sousa, Maria Alice Montes, da Silva, Paula Francinete Faustino, de Camargo, Mariana S, Gemeiner, Hendryk, Amauri, Menegário A, Gomes Cardoso, Clever, de Melo Reis, Paulo Roberto, Silveira-Lacerda, Elisângela de Paula, Batista, Alzir A

“…Antimetastatic activity, high selectivity and cytotoxicity for human tumor cell lines make ruthenium( ii ) complexes attractive for the development of new…”
Get full text

Decrease in APP and CP mRNA expression supports impairment of iron export in Alzheimer's disease patients by Guerreiro, Cláudia, Silva, Bruno, Crespo, Ângela C., Marques, Liliana, Costa, Sónia, Timóteo, Ângela, Marcelino, Erica, Maruta, Carolina, Vilares, Arminda, Matos, Mafalda, Couto, Frederico Simões, Faustino, Paula, Verdelho, Ana, Guerreiro, Manuela, Herrero, Ana, Costa, Cristina, de Mendonça, Alexandre, Martins, Madalena, Costa, Luciana

“…Alzheimer's disease (AD) is a neurodegenerative disorder of still unknown etiology and the leading cause of dementia worldwide. Besides its main…”
Get full text

Alternative polyadenylation and nonsense-mediated decay coordinately regulate the human HFE mRNA levels by Martins, Rute, Proença, Daniela, Silva, Bruno, Barbosa, Cristina, Silva, Ana Luísa, Faustino, Paula, Romão, Luísa

“…Nonsense-mediated decay (NMD) is an mRNA surveillance pathway that selectively recognizes and degrades defective mRNAs carrying premature…”
Get full text

Nonsense Mutations in Close Proximity to the Initiation Codon Fail to Trigger Full Nonsense-mediated mRNA Decay by Inácio, Angela, Silva, Ana Luísa, Pinto, Joana, Ji, Xinjun, Morgado, Ana, Almeida, Fátima, Faustino, Paula, Lavinha, João, Liebhaber, Stephen A, Romão, Luísa

“…Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs containing premature translation termination codons. In mammalian cells, a…”
Get full text

Pocket Pulse Oximetry Versus Standard Pulse Oximetry: Accuracy and Precision by da Costa, João Cordeiro, MD, Roque, Ana, NP, Faustino, Paula, NP, Lima, Ricardo, MD, Viveiros, Filipa, MD, Guimarães, Miguel, MD

Get full text

Apresentação - Dossiê História das Mulheres, Gênero e Interseccionalidades by Medeiros, Kenia Erica Gusmão, Ramos, Gilmária Salviano, Sampaio, Paula Faustino

“…É com enorme satisfação que apresentamos o Dossiê Especial “História das Mulheres, Gênero e Interseccionalidades”. Concebemos esse dossiê em função da surpresa…”
Get full text

The canonical UPF1-dependent nonsense-mediated mRNA decay is inhibited in transcripts carrying a short open reading frame independent of sequence context by Silva, Ana Luísa, Pereira, Francisco J C, Morgado, Ana, Kong, Jian, Martins, Rute, Faustino, Paula, Liebhaber, Stephen A, Romão, Luísa

“…Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs carrying premature translation termination codons. Generally, NMD is…”
Get full text

Hb Evora [alpha2-35 (B16), Ser-->Pro], a novel hemoglobin variant associated with an alpha-thalassemia phenotype by Gomes, Susana, Picanço, Isabel, Miranda, Armandina, Seixas, Maria Teresa, Oliveira, Mafalda, Romão, Luísa, Faustino, Paula

“…We report a novel mutation in the alpha2-globin gene, codon 35 (T-->C), detected in two unrelated Portuguese families. This mutation gives rise to a previously…”
Get full text

The role of HFE mutations on iron metabolism in beta-thalassemia carriers by Martins, Rute, Picanço, Isabel, Fonseca, Aidil, Ferreira, Lídia, Rodrigues, Odete, Coelho, Marília, Seixas, Teresa, Miranda, Armandina, Nunes, Baltazar, Costa, Luciana, Romão, Luísa, Faustino, Paula

“…Hereditary hemochromatosis (HH) is an autosomal recessive disorder of iron metabolism characterized by increased iron absorption and progressive storage…”
Get full text

Formação inicial de professores: análise da evasão em cursos de Pedagogia no Instituto Federal de São Paulo by Faustino-Ferber, Ana Paula, Martins, Angela Maria

“…Este artigo tem como objetivo apresentar e discutir índices de evasão do curso de Pedagogia no Instituto Federal de Educação, Ciência e Tecnologia de São Paulo…”
Get full text

Ancestry of the major long-range regulatory site of the α-globin genes in the Portuguese population with the common 3.7 kb α-thalassemia deletion by Pena, Rita, Lopes, Pedro, Gaspar, Gisela, Miranda, Armandina, Faustino, Paula

“…Background The α-Major Regulatory Element (α-MRE), also known as HS-40, is located upstream of the α-globin gene cluster and has a crucial role in the…”
Get full text

Early modification of sickle cell disease clinical course by UDP-glucuronosyltransferase 1A1 gene promoter polymorphism by Martins, Rute, Morais, Anabela, Dias, Alexandra, Soares, Isabel, Rolão, Cristiana, Ducla-Soares, J L, Braga, Lígia, Seixas, Teresa, Nunes, Baltazar, Olim, Gabriel, Romão, Luísa, Lavinha, João, Faustino, Paula

“…Elevated erythrocyte destruction in sickle cell disease (SCD) results in chronic hyperbilirubinaemia and, in a subset of patients, cholelithiasis occurs. We…”
Get full text

VCAM1, HMOX1 and NOS3 differential endothelial expression may impact sickle cell anemia vasculopathy by Silva, Marisa, Coelho, Andreia, Vargas, Sofia, Faustino, Paula

“…Endothelial dysfunction plays a major role in sickle cell anemia (SCA) systemic vasculopathy, with upregulation of adhesion molecules (e.g., VCAM-1), decreased…”
Get full text