Search Results - "Faustino, Hélio"

Bioconjugation with Maleimides: A Useful Tool for Chemical Biology by Ravasco, João M. J. M., Faustino, Hélio, Trindade, Alexandre, Gois, Pedro M. P.

“…Maleimide chemistry stands out in the bioconjugation toolbox by virtue of its synthetic accessibility, excellent reactivity, and practicability. The…”
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Ruthenium‐Catalyzed Azide–Thioalkyne Cycloadditions in Aqueous Media: A Mild, Orthogonal, and Biocompatible Chemical Ligation by Destito, Paolo, Couceiro, José R., Faustino, Hélio, López, Fernando, Mascareñas, José L.

“…The development of efficient metal‐promoted bioorthogonal ligations remains as a major scientific challenge. Demonstrated herein is that azides undergo…”
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Axially Chiral Triazoloisoquinolin-3-ylidene Ligands in Gold(I)-Catalyzed Asymmetric Intermolecular (4 + 2) Cycloadditions of Allenamides and Dienes by Francos, Javier, Grande-Carmona, Francisca, Faustino, Hélio, Iglesias-Sigüenza, Javier, Díez, Elena, Alonso, Isaac, Fernández, Rosario, Lassaletta, José M, López, Fernando, Mascareñas, José L

“…The first highly enantioselective intermolecular (4 + 2) cycloaddition between allenes and dienes is reported. The reaction provides good yields of optically…”
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Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation by Ferreira Faustino, Hélio Manuel, Silva, Maria J.S.A., Veiros, Luis Filipe, Bernardes, Gonçalo, Gois, Pedro

“…This journal is © The Royal Society of Chemistry 2016. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence We show that formyl…”
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Gold(I)-Catalyzed Cascade Cycloadditions between Allenamides and Carbonyl-Tethered Alkenes: An Enantioselective Approach to Oxa-Bridged Medium-Sized Carbocycles by Faustino, Hélio, Alonso, Isaac, Mascareñas, José L., López, Fernando

“…Gold standard: Allenamides react with aldehydes or ketones having γ, δ, or ε alkenyl groups, upon activation with suitable gold catalysts, to provide…”
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Gold(I)-Catalyzed Enantioselective [2+2+2] Cycloadditions: An Expedient Entry to Enantioenriched Tetrahydropyran Scaffolds by Varela, Iván, Faustino, Hélio, Díez, Elena, Iglesias-Sigüenza, Javier, Grande-Carmona, Francisca, Fernández, Rosario, Lassaletta, José M, Mascareñas, José L, López, Fernando

“…A straightforward and atom-economical enantioselective approach to highly substituted tetrahydropyrans is reported. The process, which consists of an…”
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Antioxidant activity of lignin phenolic compounds extracted from kraft and sulphite black liquors by Faustino, Hélio, Gil, Nuno, Baptista, Cecília, Duarte, Ana Paula

“…The antioxidant activity of the phenolic compounds present in industrial black liquors obtained from the two cooking processes (kraft and sulphite) used in…”
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Gold(i)-catalyzed [2 + 2 + 2] cycloaddition of allenamides, alkenes and aldehydes: a straightforward approach to tetrahydropyrans by Faustino, Hélio, Varela, Iván, Mascareñas, José L, López, Fernando

“…Allenamides participate as two-carbon components in an intermolecular [2 + 2 + 2] cycloaddition with alkenes and aldehydes when treated with catalytic amounts…”
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Gold(I)-Catalyzed Intermolecular [2+2] Cycloadditions between Allenamides and Alkenes by Faustino, Hélio, Bernal, Paloma, Castedo, Luis, López, Fernando, Mascareñas, José L.

“…3‐(Propa‐1,2‐dien‐1‐yl)oxazolidin‐2‐one works as an efficient two‐carbon partner in a variety of intermolecular gold‐catalyzed [2+2] cycloadditions to alkenes…”
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Gold(I)-Catalyzed Intermolecular Cycloaddition of Allenamides with α,β-Unsaturated Hydrazones: Efficient Access to Highly Substituted Cyclobutanes by Bernal-Albert, Paloma, Faustino, Hélio, Gimeno, Ana, Asensio, Gregorio, Mascareñas, José L, López, Fernando

“…α,β-Unsaturated N,N-dialkyl hydrazones undergo a mild [2 + 2] cycloaddition to allenamides when treated with a suitable gold catalyst. The method, which…”
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Secondary Modification of S100B Influences Anti Amyloid-β Aggregation Activity and Alzheimer's Disease Pathology by Coelho, Romina, De Benedictis, Chiara A, Sauer, Ann Katrin, Figueira, António J, Faustino, Hélio, Grabrucker, Andreas M, Gomes, Cláudio M

“…Proteinaceous aggregates accumulate in neurodegenerative diseases such as Alzheimer's Disease (AD), inducing cellular defense mechanisms and altering the redox…”
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Enantioselective Gold(I)-Catalyzed Intramolecular (4+3) Cycloadditions of Allenedienes by Alonso, Isaac, Faustino, Hélio, López, Fernando, Mascareñas, José L.

“…Allene‐tethered dienes (1) undergo an intramolecular and highly enantioselective (4+3) cycloaddition when treated with suitable chiral phosphoramidite/gold(I)…”
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Hypervalent Iodine(III) Reagents with Transferable Primary Amines: Structure and Reactivity on the Electrophilic α‑Amination of Stabilized Enolates by Poeira, Diogo L, Negrão, Ana Cláudia R, Faustino, Hélio, Coelho, Jaime A. S, Gomes, Clara S. B, Gois, Pedro M. P, Marques, M. Manuel B

“…A new family of hypervalent iodine reagents containing transferable primary amine groups is described. Benziodoxolone-based reagents were synthesized on the…”
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Synthesis of 4-substituted-3-Hydroxyquinolin-2(1H)-ones with anticancer activity by Paterna, Roberta, Padanha, Rita, Russo, Roberto, Frade, Raquel F.M., Faustino, Hélio, Gois, Pedro M.P.

“…Herein we show that the 3-hydroxyquinolin-2(1H)-one (3HQ) core is a suitable platform to develop new compounds with anticancer activity against MCF-7 (IC50 up…”
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Efficient Amino‐Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS‐Activated Acrylamides by Silva, Maria J. S. A., Faustino, Hélio, Coelho, Jaime A. S., Pinto, Maria V., Fernandes, Adelaide, Compañón, Ismael, Corzana, Francisco, Gasser, Gilles, Gois, Pedro M. P.

“…Widely used reagents in the peptide functionalization toolbox, Michael acceptors and N‐hydroxysuccinimide (NHS) activated esters, are combined in NHS‐activated…”
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Mechanistic Intricacies of Gold-Catalyzed Intermolecular Cycloadditions between Allenamides and Dienes by Montserrat, Sergi, Faustino, Hélio, Lledós, Agustí, Mascareñas, Jose L., López, Fernando, Ujaque, Gregori

“…The mechanism of the gold‐catalyzed intermolecular cycloaddition between allenamides and 1,3‐dienes has been explored by means of a combined experimental and…”
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Gold(I)-Catalyzed Cascade Cycloadditions between Allenamides and Carbonyl-Tethered Alkenes: An Enantioselective Approach to Oxa-Bridged Medium-Sized Carbocycles by Faustino, Hélio, Alonso, Isaac, Mascareñas, José L., López, Fernando

“…Goldstandard: Allenamide reagieren unter Goldkatalyse gemäß einer formalen Cycloadditionskaskade mit Aldehyden oder Ketonen, die γ‐, δ‐ oder ε‐Alkenylgruppen…”
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Diazaborines Are a Versatile Platform to Develop ROS‐Responsive Antibody Drug Conjugates by António, João P. M., Carvalho, Joana Inês, André, Ana S., Dias, Joana N. R., Aguiar, Sandra I., Faustino, Hélio, Lopes, Ricardo M. R. M., Veiros, Luis F., Bernardes, Gonçalo J. L., Silva, Frederico A., Gois, Pedro M. P.

“…Antibody–drug conjugates (ADCs) are a new class of therapeutics that combine the lethality of potent cytotoxic drugs with the targeting ability of antibodies…”
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Interactive Bioconjugation at N‐Terminal Cysteines by Using O‐Salicylaldehyde Esters towards Dual Site‐Selective Functionalization by Silva, Maria J. S. A., Cavadas, Rafaela A. N., Faustino, Hélio, Veiros, Luís F., Gois, Pedro M. P.

“…N‐terminal Cys modification has been intensively studied to produce homogeneous bioconjugates essentially through two modes of reaction: reversible…”
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Bioactive Compounds of Portuguese Fruits with PDO and PGI by Farinha, Diana, Faustino, Hélio, Nunes, Catarina, Sales, Hélia, Pontes, Rita, Nunes, João

“…The European Union has established two designations, Protected Designation of Origin (PDO) and Protected Geographical Indication (PGI), to guarantee the…”
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