Search Results - "Faust, Guy"

Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent by BOOCOCK, David J, FAUST, Guy E. S, STEWARD, William P, BRENNER, Dean E, PATEL, Ketan R, SCHINAS, Anna M, BROWN, Victoria A, DUCHARME, Murray P, BOOTH, Tristan D, CROWELL, James A, PERLOFF, Marjorie, GESCHER, Andreas J

“…The red grape constituent resveratrol possesses cancer chemopreventive properties in rodents. The hypothesis was tested that, in healthy humans, p.o…”
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Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography by Boocock, David J., Patel, Ketan R., Faust, Guy E.S., Normolle, Daniel P., Marczylo, Timothy H., Crowell, James A., Brenner, Dean E., Booth, Tristan D., Gescher, Andreas, Steward, William P.

“…We describe a reversed-phase HPLC method that uses gradient elution and UV detection (325 nm) to determine levels of resveratrol and identify six major…”
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Impact of age on the toxicity of immune checkpoint inhibition by Samani, Amit, Zhang, Shuai, Spiers, Laura, Suwaidan, Ali Abdulnabi, Merrick, Sophie, Tippu, Zayd, Payne, Miranda, Faust, Guy, Papa, Sophie, Fields, Paul, Van Hemelrijck, Mieke, Josephs, Debra H

“…Indications for immune checkpoint inhibitor therapy are increasing. As the population ages, many patients receiving such drugs will be older adults. Such…”
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The Experiences of Patients With Adjuvant and Metastatic Melanoma Using Disease-Specific Social Media Communities in the Advent of Novel Therapies (Excite Project): Social Media Listening Study by Faust, Guy, Booth, Alison, Merinopoulou, Evie, Halhol, Sonia, Tosar, Heena, Nawaz, Amir, Szlachetka, Magdalena, Chiu, Gavin

“…Immunotherapy and targeted therapy treatments are novel treatments available for patients with metastatic and adjuvant melanoma. As recently approved…”
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Understanding the Lived Experiences of Patients With Melanoma: Real-World Evidence Generated Through a European Social Media Listening Analysis by Chauhan, Jyoti, Aasaithambi, Sathyaraj, Márquez-Rodas, Iván, Formisano, Luigi, Papa, Sophie, Meyer, Nicolas, Forschner, Andrea, Faust, Guy, Lau, Mike, Sagkriotis, Alexandros

“…Cutaneous melanoma is an aggressive malignancy that is proposed to account for 90% of skin cancer-related mortality. Individuals with melanoma experience both…”
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NICE 2022 Guidelines on the Management of Melanoma: Update and Implications by Lakshmi, Aiswarya, Shah, Rahul, Begaj, Ardit, Jayarajan, Rajshree, Ramachandran, Sanjeev, Morgan, Bruno, Faust, Guy, Patel, Nakul

“…In July 2022 NICE updated the guidelines on management of melanoma by lowering the number of follow-up appointments and sentinel lymph node biopsy (SLNB) but…”
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A Randomized, Double-Blind, Biomarker-Selected, Phase II Clinical Trial of Maintenance Poly ADP-Ribose Polymerase Inhibition With Rucaparib Following Chemotherapy for Metastatic Urothelial Carcinoma by Crabb, Simon J, Hussain, Syed, Soulis, Eileen, Hinsley, Samantha, Dempsey, Laura, Trevethan, Avril, Song, YeePei, Barber, Jim, Frew, John, Gale, Joanna, Faust, Guy, Brock, Susannah, McGovern, Ursula, Parikh, Omi, Enting, Deborah, Sundar, Santhanam, Ratnayake, Gihan, Lees, Kathryn, Birtle, Alison J, Powles, Thomas, Jones, Robert J

“…A DNA repair deficiency (DRD) phenotype exists within a subset of metastatic urothelial carcinomas (mUC) predicting benefit from platinum-based chemotherapy…”
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Imaging Modality and Frequency in Surveillance of Stage I Seminoma Testicular Cancer: Results From a Randomized, Phase III, Noninferiority Trial (TRISST) by Joffe, Johnathan K, Cafferty, Fay H, Murphy, Laura, Rustin, Gordon J S, Sohaib, Syed A, Gabe, Rhian, Stenning, Sally P, James, Elizabeth, Noor, Dipa, Wade, Simona, Schiavone, Francesca, Swift, Sarah, Dunwoodie, Elaine, Hall, Marcia, Sharma, Anand, Braybrooke, Jeremy, Shamash, Jonathan, Logue, John, Taylor, Henry H, Hennig, Ivo, White, Jeff, Rudman, Sarah, Worlding, Jane, Bloomfield, David, Faust, Guy, Glen, Hilary, Jones, Rachel, Seckl, Michael, MacDonald, Graham, Sreenivasan, Thiagarajan, Kumar, Satish, Protheroe, Andrew, Venkitaraman, Ramachandran, Mazhar, Danish, Coyle, Victoria, Highley, Martin, Geldart, Tom, Laing, Robert, Kaplan, Richard S, Huddart, Robert A

“…Survival in stage I seminoma is almost 100%. Computed tomography (CT) surveillance is an international standard of care, avoiding adjuvant therapy. In this…”
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A randomised, double blind, phase II clinical trial of maintenance cabozantinib following chemotherapy for metastatic urothelial carcinoma (mUC): Final analysis of the ATLANTIS cabozantinib comparison by Jones, Robert J., Hussain, Syed A., Birtle, Alison Jane, Song, Yee Pei, Enting, Deborah, Faust, Guy, Hilman, Serena, Jagdev, Satinder, McGovern, Ursula Brigid, Parikh, Omi, Lewis, Amy, Soulis, Eileen, Trevethan, Avril, Crabb, Simon J., Powles, Thomas

“…LBA4505 Background: Platinum-based chemotherapy (PBC) is an active first line therapy in mUC, but duration of response is usually short. We hypothesised that…”
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Belzutifan plus lenvatinib for patients (pts) with advanced clear cell renal cell carcinoma (ccRCC) after progression on a PD-1/L1 and VEGF inhibitor: Preliminary results of arm B5 of the phase 1/2 KEYMAKER-U03B study by Albiges, Laurence, Beckermann, Katy, Miller, Wilson H., Goh, Jeffrey C., Gajate, Pablo, Harris, Carole A., Suárez, Cristina, Peer, Avivit, Park, Se Hoon, Stadler, Walter Michael, Weickhardt, Andrew James, Faust, Guy, Fong, Peter C.C., Waddell, Tom, Venugopal, Balaji, Yin, Lina, Wang, Ding, Perini, Rodolfo F., Powles, Thomas

“…4553 Background: The oral HIF-2α inhibitor belzutifan demonstrated antitumor activity with manageable safety as monotherapy in pts with heavily pretreated…”
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Spectrochemical analysis highlights similarities in adenocarcinomas irrespective of primary tissue origins by Bury, Danielle, Faust, Guy, Paraskevaidi, Maria, Dawson, Timothy P, Martin, Francis L.

“…Abstract only e13551 Background: Identification of primary tissue origin of brain metastases can be histopathologically challenging. Initial diagnosis of…”
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Metastatic testicular choriocarcinoma presenting as eyelid swelling and ptosis by Sivagnanasithiyar, Tharsica, Okafor, Linda, Faust, Guy, Mudhar, Hardeep Singh, Sii, Samantha, Knapp, Christopher, Sampath, Raghavan

“…A 34-year-old man presented with an 8-day history of swelling and ptosis affecting the right upper eyelid. An MRI scan showed right superior rectus…”
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A randomized, double blind, biomarker selected, phase II clinical trial of maintenance PARP inhibition following chemotherapy for metastatic urothelial carcinoma (mUC): Final analysis of the ATLANTIS rucaparib arm by Crabb, Simon J., Hussain, Syed A., Soulis, Eileen, Hinsley, Samantha, Dempsey, Laura, Trevethan, Avril, Song, Yee Pei, Barber, Jim, Frew, John A., Gale, Joanna, Faust, Guy, Brock, Susannah Joy, McGovern, Ursula Brigid, Parikh, Omi, Enting, Deborah, Sundar, Santhanam, Ratnayake, Gihan, Lees, Kathryn, Powles, Thomas, Jones, Robert J.

“…Abstract only 436 Background: A subset of mUC exhibits a DNA repair deficiency (DRD) phenotype predicting benefit from platinum based chemotherapy (PBC). We…”
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Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma by Culliford, Richard, Lawrence, Samuel E. D., Mills, Charlie, Tippu, Zayd, Chubb, Daniel, Cornish, Alex J., Browning, Lisa, Kinnersley, Ben, Bentham, Robert, Sud, Amit, Pallikonda, Husayn, Frangou, Anna, Gruber, Andreas J., Litchfield, Kevin, Wedge, David, Larkin, James, Turajlic, Samra, Houlston, Richard S.

“…Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer, but a comprehensive description of its genomic landscape is lacking. We…”
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Phenotyping Metastatic Brain Tumors Applying Spectrochemical Analyses: Segregation of Different Cancer Types by Bury, Danielle, Faust, Guy, Paraskevaidi, Maria, Ashton, Katherine M., Dawson, Timothy P., Martin, Francis L.

“…Metastatic brain tumors represent a significant proportion of tumors identified intraoperatively. A rapid diagnostic method, circumventing the need for…”
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Identification of a microbiome signature predicting immune checkpoint inhibitor outcomes across multiple cancer types in the MITRE study by Corrie, Philippa Gail, Welsh, Sarah Joanne, Stewart, Grant D., Doherty, Gary, Vervier, Kevin, Neville, Anne, Parkinson, Christine, Fife, Kate, Faust, Guy, Jayaprakash, Kamalram Thippu, Geldart, Thomas R., Brown, Ewan, Wheater, Matthew, Nobes, Jenny Penelope, Bruce, David, Demiris, Nikos, Dalchau, Katy Marie, Adams, David, Robinson, Mat, Lawley, Trevor

“…Abstract only TPS2665 Background: The gut microbiome is implicated as a biomarker of response to immune checkpoint inhibitors (ICIs), based on preclinical…”
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Assessing Outcomes and Prognostic Factors for First-Line Therapy in Elderly Patients With Metastatic Renal Cell Carcinoma: Real-Life Data From a Single United Kingdom Institution by Uccello, Mario, Alam, Tasnim, Abbas, Haider, Nair, Ajith, Paskins, Jennifer, Faust, Guy

“…Elderly metastatic renal cell carcinoma (mRCC) patients are under-represented in clinical trials, whose results are therefore difficult to translate into…”
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The impact of patient age on toxicity and efficacy of immunotherapy agents by Zhang, Shuai, Samani, Amit, Spiers, Laura, Tippu, Zayd, Suwaidan, Ali Abdulnabi, Merrick, Sophie, Van Hemelrijck, Mieke, Payne, Miranda, Faust, Guy, Papa, Sophie, Josephs, Debra Hannah

“…Abstract only e15116 Background: Little data exists for the use of immune checkpoint inhibitors (ICI) in patients ≥80y old. Ageing is associated with…”
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Atezolizumab (atezo) therapy for upper tract (UT) urothelial carcinoma (UC): Subgroup analysis of the single-arm international SAUL study in pretreated locally advanced/metastatic urinary tract carcinoma by Sternberg, Cora N., Loriot, Yohann, Tambaro, Rosa, Buttigliero, Consuelo, Morelli, Franco, Papai, Zsuzsanna, Retz, Margitta, Necchi, Andrea, Van Der Heijden, Michiel Simon, Faust, Guy, Cardona Zorrilla, Andres Felipe, Lainez, Nuria, Panni, Stefano, Etxaniz, Olatz, Krieger, Laurence, Mendez Vidal, Maria Jose José, Los, Maartje, de Ducla, Sabine, Fear, Simon, Merseburger, Axel Stuart

“…Abstract only 488 Background: UTUC is rarer than bladder UC and typically responds poorly to standard chemotherapy. Analysis of 220 biomarker-evaluable…”
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Severe inflammatory ileitis resulting in ileal perforation in association with combination immune checkpoint blockade for metastatic malignant melanoma by Mohamed, Ali Abdulnabi, Richards, Cathy J, Boyle, Kirsten, Faust, Guy

“…Immune checkpoint inhibitors have become standard of care in metastatic malignant melanoma management. Despite superior effectiveness to chemotherapy,…”
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