Distribution of EGFR Mutations in 10,607 Russian Patients with Lung Cancer

Introduction This study was aimed to evaluate distribution of epidermal growth factor receptor (EGFR) mutations in a large series of Russian lung cancer (LC) patients. Methods 10,607 LC samples were considered for EGFR analysis; EGFR status was successfully determined in 10,426 cases (98.3 %), indic...

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Published in:	Molecular diagnosis & therapy Vol. 20; no. 4; pp. 401 - 406
Main Authors:	Imyanitov, Evgeny N., Demidova, Irina A., Gordiev, Marat G., Filipenko, Maxim L., Kekeyeva, Tatyana V., Moliaka, Yuri K., Gervas, Polina A., Kozhemyako, Valeriy B., Vodolazhskiy, Dmitriy I., Sergeyeva, Liubov A., Fattakhova, Dinara U., Iyevleva, Aglaya G., Mitiushkina, Natalia V., Kuligina, Ekatherina Sh, Barinov, Alexey A., Mommaeva, Meriiam S., Aleksakhina, Svetlana N., Tsimafeyeu, Ilya V., Tjulandin, Sergey A.
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-08-2016 Springer Nature B.V
Subjects:	Adolescent Adult Age Age Distribution Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Cancer Research Ethics Female Females Gender Histology Human Genetics Humans Internet resources Laboratory Medicine Lung cancer Lung Neoplasms - epidemiology Lung Neoplasms - genetics Male Middle Aged Molecular Medicine Mortality Multivariate analysis Mutation Original Research Article Patients Pharmacotherapy Population Surveillance Prevalence Receptor, Epidermal Growth Factor - genetics Risk Factors Russia - epidemiology Smoking Young Adult Epidermal Growth Factor Receptor Epidermal Growth Factor Receptor Mutation Lung Cancer Case Gefitinib Epidermal Growth Factor Receptor Gene
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Summary:	Introduction This study was aimed to evaluate distribution of epidermal growth factor receptor (EGFR) mutations in a large series of Russian lung cancer (LC) patients. Methods 10,607 LC samples were considered for EGFR analysis; EGFR status was successfully determined in 10,426 cases (98.3 %), indicating relatively low failure rate. Results EGFR mutations (ex19del and L858R) were detected in 1759/8716 (20.2 %) adenocarcinomas, 28/669 (4.2 %) squamous cell carcinomas (SCC) and 8/119 (6.7 %) large cell carcinomas. The occurrence of EGFR mutations in adenocarcinomas gradually increased with age, being attributed mainly to the increment of the L858R frequency in non-smokers (patients aged 18–30 years: 1/27 (3.7 %); 31–40 years: 5/98 (5.1 %); 41–50 years: 18/276 (6.5 %); 51–60 years: 102/944 (10.8 %); 61–70 years: 138/1011 (13.7 %); 71–80 years: 85/496 (17.1 %); 81–100 years: 5/27 (18.5 %); p < 0.0001). The EGFR mutation was detected in 804/2107 (38.2 %) non-smoking women versus 125/806 (15.5 %) non-smoking men ( p < 0.0001), while the corresponding figures for smokers were 60/273 (22.0 %) versus 147/2214 (6.6 %) ( p < 0.0001). The obtained gender-related data differ from the estimates obtained in Asian studies; they indicate that increased prevalence of EGFR mutations in white females may not be entirely attributed to the low prevalence of smoking, but is likely to be related to gender factors per se. Conclusion Biological causes of distinct age- and gender-related distribution of EGFR mutations in LC deserve further investigation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1177-1062 1179-2000
DOI:	10.1007/s40291-016-0213-4